DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ap3b1 and rb

DIOPT Version :9

Sequence 1:XP_006517586.1 Gene:Ap3b1 / 11774 MGIID:1333879 Length:1118 Species:Mus musculus
Sequence 2:NP_001162664.2 Gene:rb / 31381 FlyBaseID:FBgn0003210 Length:1160 Species:Drosophila melanogaster


Alignment Length:1201 Identity:586/1201 - (48%)
Similarity:772/1201 - (64%) Gaps:139/1201 - (11%)


- Green bases have known domain annotations that are detailed below.


Mouse     2 SSNSFA---YNEQSGGGEAAELGQEATSTISPSGAFGLFSSDWKKNEDLKQMLESNKDSAKLDAM 63
            :||.||   |.|:...|...|.|.:      |:.....|.||.:|::||||||:||||..||:||
  Fly     6 ASNPFAMSTYVERPQMGLDVEFGAD------PASGAAFFQSDGRKHDDLKQMLDSNKDGLKLEAM 64

Mouse    64 KRIVGMIAKGKNASELFPAVVKNVASKNIEIKKLVYVYLVRYAEEQQDLALLSISTFQRALKDPN 128
            |||:||||:|::||:|||||||||.|||||:||||||||||||||||||||||||||||||||||
  Fly    65 KRIIGMIARGRDASDLFPAVVKNVVSKNIEVKKLVYVYLVRYAEEQQDLALLSISTFQRALKDPN 129

Mouse   129 QLIRASALRVLSSIRVPIIVPVMMLAIKEASADLSPYVRKNAAHAIQKLYSLDPEQKEMLIEVIE 193
            ||||||||||||||||.:|||::||||::::|||||||||.|||||.||||||.:||:.|:.|||
  Fly   130 QLIRASALRVLSSIRVSMIVPIVMLAIRDSAADLSPYVRKTAAHAIPKLYSLDADQKDELVMVIE 194

Mouse   194 KLLKDKSTLVAGSVVMAFEEVCPDRIDLIHRNYRKLCNLLVDVEEWGQVVIIHMLTRYARTQFVS 258
            |||.|::|||.||.||||:||||:|:||||:|||||||.|:||:|||||:||:|||||||||||.
  Fly   195 KLLSDRTTLVVGSAVMAFDEVCPERVDLIHKNYRKLCNFLLDVDEWGQVIIINMLTRYARTQFVD 259

Mouse   259 PWREDGGLEDN-------EKNFYESE----------EEEEEKEKSSR-----------------K 289
            |..:|..|.::       .:.||:..          ..::||.|||.                 .
  Fly   260 PNADDEDLVNDGLGETPVSERFYDESSHSSSHSDDGSSDDEKNKSSTNNKNNGGGNGSRTPSSPS 324

Mouse   290 KSYAMDPDHRLLIRNTKPLLQSRNAAVVMAVAQLYWHISPKSEAGVISKSLVRLLRSNREVQYIV 354
            .||.:|.|||||:|.||||||||||:|||||||||.|::||:|..:|:|:|:|||||::|||.:|
  Fly   325 NSYHIDVDHRLLLRQTKPLLQSRNASVVMAVAQLYHHVAPKNEVQLIAKALIRLLRSHKEVQSVV 389

Mouse   355 LQNIATMSIERKGMFEPYLKSFYVRSTDPTMIKTLKLEILTNLANEANISTLLREFQTYVRSQDK 419
            |..||:||.:||.:|||:||||:||::|||.||.|||:||||||:..:||.:|||||||:.|.|:
  Fly   390 LNCIASMSTKRKAIFEPHLKSFFVRTSDPTHIKLLKLDILTNLASAGSISLILREFQTYISSSDR 454

Mouse   420 QFAAATIQTIGRCATSISEVTDTCLNGLVCLLSNRDEIVVAESVVVIKKLLQMQPAQHGEIIRHM 484
            .|.|||||.|||||:||.|||:|||:|||.||||.||.||||||||||:|||.:.|:|.|||..|
  Fly   455 SFVAATIQAIGRCASSIKEVTETCLSGLVHLLSNHDEHVVAESVVVIKRLLQTKAAEHFEIITQM 519

Mouse   485 AKLLDSITVPVARASILWLIGENCERVPKIAPDVLRKMAKSFTSEDDLVKLQILNLAAKLYLTNS 549
            |||:|.|.||.|||:|:|||||..|:||.|||||||||||||..|.|:||||:|||..||||||.
  Fly   520 AKLIDYINVPAARAAIIWLIGEYNEKVPLIAPDVLRKMAKSFVDEQDVVKLQVLNLGVKLYLTNP 584

Mouse   550 KQTKLLTQYILNLGKYDQNYDIRDRTRFIRQLIVP-NEKSGALSKYAKKIFLAPKPAPLLESPFK 613
            :||.||.||:..|.:||.|||:|||.||:||:|.| :..|..||::|:::|||.||||:.||.::
  Fly   585 EQTSLLCQYVFTLARYDPNYDVRDRARFLRQIIFPASGTSSVLSQHARQVFLASKPAPVPESKYR 649

Mouse   614 DRDRFQLGTLSHTLNIKASGYLELSNWPEVAPDPSVRNVEVIESAK---EWTPLGKTK------- 668
            |.:.||||:|||.||:.|:||.||..:|.:.||.||||:......|   |.:|.|.:|       
  Fly   650 DGNNFQLGSLSHYLNMPAAGYKELPAFPVIPPDSSVRNIAGFMQDKLPGEDSPSGHSKDKSGREG 714

Mouse   669 -KEKPM---KKFYSESEEEEDEDEDEDEEEEEKEDEDENPSDSSSDSESGSGSESGDTGTEDSSE 729
             |||..   |.|.|||:::                       ||:.|||||.|.||.:.:|..|:
  Fly   715 GKEKGAGGEKGFLSESDDK-----------------------SSAYSESGSSSGSGTSDSESDSD 756

Mouse   730 DSSSGQDSETGSQAEAERQKVAKRNSKTKRKSDSENRE------------KKNENSKASE--SSS 780
            .|.|..:.|    .|.::|:..|.:|..:|..|:.:.|            ..|.|::.|.  |.|
  Fly   757 GSGSSDEEE----EEVQKQQPTKVSSVKERLIDAGSNELAATSSPVKATINNNNNARGSSGTSDS 817

Mouse   781 EESSSMEDSSSESESESGSDSE-----------PAPRNVAPAKERKPQQERHPPSKDVFLLDLDD 834
            |:||:...|||: :|.||||:|           ..|..:....|::|:|.....:.|: ||||||
  Fly   818 EDSSAYSGSSSD-DSASGSDNEVKKNETKTDTGTKPEKLKEKHEKQPEQTAVKSNLDL-LLDLDD 880

Mouse   835 FNPVSTPVALP------TPALSPSLIADLEGLNLSTSSSVINVSTPVFVPTKTHELLHRMHGKGL 893
            ..|:. ||..|      ||. :|.:......|....:.:.:.:..|..:..|..|||:::.|.||
  Fly   881 IPPIG-PVMTPSLGGFLTPG-TPMMAGQAAPLQPQHARNRVELVGPSHIEFKHKELLNKVSGHGL 943

Mouse   894 AAHYCFPRQPCIFSDKMVSVQITLTNTSDRKIENIHIGGKGLPVGMQMHAFHPIDSLEPKGSVTV 958
            ...|.|.|.|.::|..|.|:::...|..:::|..|.:|...||.|||::.|.||..|:|:.:.:.
  Fly   944 HLAYRFTRSPHLYSSSMCSIELQFQNRGEKEITAIRLGQTTLPAGMQLNEFAPITVLQPQQTASG 1008

Mouse   959 SVGIDFCDSTQTASFQLCTKDDCFNVTLQPPVGELLSPVAMSEKDFKKEQACLCFTSVCSANQGT 1023
            .:|:||.|||.....:|.:......:.|:||||||:..|.:.|...::|:|             .
  Fly  1009 VLGVDFNDSTHAVDLELLSSAGSSRLQLKPPVGELVRSVQIGESCHREERA-------------K 1060

Mouse  1024 LTGMNETSATLIAAPQNFTPSMIL-QKV---VNVANLGAVPSSQDNVHRFAARTVHSGSLMLVTV 1084
            |.||||....|....|:....:.| |||   :|||:..:  ||...:|.||.:|:.|.||:|:|:
  Fly  1061 LRGMNEHQCELRGLRQDLIDVVALRQKVFESINVAHTHS--SSSGQLHCFAGQTLSSKSLVLLTL 1123

Mouse  1085 ELKEGSTAQLIINTEKTVIGSVLLRELKPVL 1115
            :.|......|::|.||.||||::|.||:..|
  Fly  1124 DWKTEDALTLLVNCEKMVIGSMVLNELRNAL 1154

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ap3b1XP_006517586.1 Adaptin_N 46..582 CDD:366724 379/569 (67%)
HEAT repeat 116..144 CDD:293787 27/27 (100%)
HEAT repeat 150..180 CDD:293787 21/29 (72%)
HEAT repeat 188..213 CDD:293787 17/24 (71%)
SEEEED <734..812 CDD:373302 26/102 (25%)
AP3B1_C 824..969 CDD:373301 49/150 (33%)
rbNP_001162664.2 Adaptin_N 40..621 CDD:279882 384/580 (66%)
HEAT repeat 48..73 CDD:293787 19/24 (79%)
HEAT repeat 117..144 CDD:293787 26/26 (100%)
Cnd1 129..>252 CDD:289487 92/122 (75%)
HEAT repeat 147..179 CDD:293787 22/31 (71%)
HEAT repeat 188..214 CDD:293787 17/25 (68%)
AP3B1_C 881..1019 CDD:291462 42/139 (30%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167833471
Domainoid 1 1.000 757 1.000 Domainoid score I87
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H68125
Inparanoid 1 1.050 1003 1.000 Inparanoid score I293
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG54550
OrthoDB 1 1.010 - - D147356at33208
OrthoFinder 1 1.000 - - FOG0002006
OrthoInspector 1 1.000 - - otm43466
orthoMCL 1 0.900 - - OOG6_101595
Panther 1 1.100 - - LDO PTHR11134
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2031
SonicParanoid 1 1.000 - - X1748
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1514.940

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