DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ap2a1 and AP-1gamma

DIOPT Version :9

Sequence 1:	NP_031484.1	Gene:	Ap2a1 / 11771	MGIID:	101921	Length:	977	Species:	Mus musculus
Sequence 2:	NP_788891.2	Gene:	AP-1gamma / 31842	FlyBaseID:	FBgn0030089	Length:	982	Species:	Drosophila melanogaster

Alignment Length:	982	Identity:	249/982 - (25%)
Similarity:	424/982 - (43%)	Gaps:	216/982 - (21%)

- Green bases have known domain annotations that are detailed below.

Mouse     1 MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFI 65
            ||..::   :|.|   |..||..::...|...:|||.|.|||.|:.:   |...:.:.:.|||:|
  Fly    42 MPTPTR---LRDL---IRQIRAARTAAEERAVVNKECAYIRSTFREE---DSVWRCRNIAKLLYI 97

Mouse    66 FLLGHDIDFGHMEAVNLLSSNKYTEKQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMCL 130
            .:||:...||.:|.:.|.:|.::|:|:||||...:|::...::..||.|.:||||.|.....:.|
  Fly    98 HMLGYPAHFGQLECLKLTASTRFTDKRIGYLGAMLLLDERQDVHLLITNCLKNDLNSSTQFVVGL 162

Mouse   131 ALHCIANVGSREMGEAFAADIPRILVAGDSMDSVKQSAALCLLRLYKASPDLVPMGEWTARVVHL 195
            ||..:..:.|.||....|:::.|::.:.::.  :::.|.||..|:.:..|:|:.:  :......|
  Fly   163 ALCTLGAIASPEMARDLASEVERLMKSPNTY--IRKKATLCAFRVIRRVPELMEI--FLPATRSL 223

Mouse   196 LNDQHMGVVTAAVSLITCLCKKNPDDF---------KTCISLAVSRLSRIVSSASTDLQDYTYYF 251
            |::::.|::...|:|||.:|:.:.|..         :..:...|..|..::....:...|.:  .
  Fly   224 LSEKNHGILITGVTLITEMCENSSDTLMHFKKDSGNREIVPNLVRILKNLILGGYSPEHDVS--G 286

Mouse   252 VPAPWLSVKLLRLLQC--YPPPEDAAVKGRLVECLETVLNKAQEPPKSKKVQHSNAKNAILFETI 314
            |..|:|.||:||||:.  :..| ||:      |.:..:|.:.....::.|    |..|.||:||:
  Fly   287 VSDPFLQVKILRLLRILGHNDP-DAS------EAMNDILAQVATNTETSK----NVGNTILYETV 340

Mouse   315 SLIIHYDSEPNLLVRACNQLGQFLQHRETNLRYLALESMCTLASSEFSHEAVKTHIDTVINALKT 379
            ..|:...||..|.|.|.|.||:||.:.:.|:||:||.::.....::.|  ||:.|..|::..||
  Fly   341 LSIMDIRSEGGLRVLAVNILGRFLLNSDKNIRYVALNTLLRTVHADTS--AVQRHRTTILECLK- 402

Mouse   380 ERDVSVRQRAADLLYAMCDRSNAKQIVSEMLRYLETADYAIREEIVLKVAILAEKYAVDYSWYVD 444
            :.|||:|:||.:|.:|:.:..|.:.:..|:|.:||.||...:.:....:.:.||:|:....|::|
  Fly   403 DPDVSIRRRAMELSFALINAQNIRTMTKELLLFLEKADAEFKAQCSSGMILAAERYSPTTRWHLD 467

Mouse   445 TILNLIRIAGDYVSEEVWYRVLQIVTNRD-DVQGYAAKTVFEALQ-APACHEN--MVKVGGYILG 505
            |.|:::..||:||.::|....:|:|::.. ..|.|.....:|:|| |..|.:.  :::|..:.:|
  Fly   468 TQLSVLIAAGNYVRDDVVSSTIQLVSSSPVPEQTYITNRFWESLQVANHCEDKQPLLQVAVWAIG 532

Mouse   506 EFGNLI---AGDPRSSPPVQFSLL--HSKF---HLCSVATRALLLSTYIKFINLFPETKATIQGV 562
            |:|:|.   |.:.....|.:..|:  :.||   ...|..::...|.:..|......:....||.:
  Fly   533 EYGDLFMYGANEDEFERPTESDLIAVYYKFLTSAQVSTTSKQYALVSLAKLSTRLQQCVEEIQAL 597

Mouse   563 LRA-GSQLRNADVELQQRAVEYLTLSSVASTDVLATVLEEMPPFPERESSI-LAKLKRKKGPGAA 625
            :.: ||.|   :|:||||.||:        |.:........||..|:..:: ::::..:.|....
  Fly   598 ITSFGSHL---NVDLQQRGVEF--------TQLFGHYKHLRPPLLEKMPAMQISRISSQNGESGG 651

Mouse   626 SALDDSRRDTSSNDINGG-------VEPTPST--------------------------------- 650
            .:.||:..|...|.:.||       :|...:|
  Fly   652 GSFDDNSPDVIENGVEGGGGGGHSLIESNMNTLGDNTNILLDLLGSTDLSAGGAGDLVAATDLSN 716

Mouse   651 -------------VSTPSPSADLLGL----RAAPPPAAPPAPVGG-------------------- 678
                         |:..|.:.|||.|    .:||......||.||
  Fly   717 AVHKKNSRNANDVVAPVSNNQDLLDLLDLDLSAPSSTTTGAPAGGGGGGGIVALVGDNNQSSAAN 781

Mouse   679 --NLL--VDV--FSDGPTAQPSLGPTPEEAFLSEL----EPPAPESPMA---------------L 718
              |:|  :|:  |..|..:..|: ||......|.|    .|||....:|               |
  Fly   782 MNNMLGGLDLGGFGSGLDSSASI-PTNGNDLASMLGGLGAPPAASPSLAASAPVGNLIDGHAGSL 845

Mouse   719 LADPAPAADPGPEDIGPPIP-----EADELLNKFV------C--------KNSGVLFENQLLQIG 764
            |||..|.|......:.|..|     :.|.||.:.|      |        .||....:..|||..
  Fly   846 LADLNPTAASNNVVVPPQGPRLTALDKDGLLVQLVSVRGSDCMRIYMTTTNNSDNTLDQYLLQAA 910

Mouse   765 VKSEFRQNLGRMYLFYGNKTSVQFQNFLP--TVVHPGDLQTQ--LAVQTK--------RVAAQVD 817
            |:..|                 |.|...|  :|:.||.:.||  ..|.|.        |:...:|
  Fly   911 VQRSF-----------------QLQMLTPSGSVLPPGGVITQEMRVVATSNATLRMRLRIQYVLD 958

Mouse   818 GGAQVQQ 824
            |..||:|
  Fly   959 GQQQVEQ 965

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ap2a1	NP_031484.1	Adaptin_N	29..591	CDD:366724	167/585 (29%)
		HEAT repeat	332..355	CDD:293787	10/22 (45%)
		HEAT repeat	369..398	CDD:293787	12/28 (43%)
		HEAT repeat	408..434	CDD:293787	7/25 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	614..702		29/170 (17%)
		Alpha_adaptinC2	755..858	CDD:197886	21/82 (26%)
		Alpha_adaptin_C	864..972	CDD:367023
AP-1gamma	NP_788891.2	Adaptin_N	68..624	CDD:279882	167/589 (28%)
AP-1gamma	NP_788891.2	Alpha_adaptinC2	869..972	CDD:197886	28/114 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4354
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53727
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820