Protein Alignment Ap1g1 and AP-1gamma

DIOPT Version :10

• Sequence 1: NP_033807.2
• Gene: Ap1g1 / 11765
• MGIID: 101919
• Length: 825
• Species: Mus musculus
• Sequence 2: NP_788891.2
• Gene: AP-1gamma / 31842
• FlyBaseID: FBgn0030089
• Length: 982
• Species: Drosophila melanogaster
• Alignment Length: 945
• Identity: 470/945 - (49%)
• Similarity: 603/945 - (63%)
• Gaps: 135/945 - (14%)

Mouse     1 MPAPIRLRELIRTIRTARTQAEEREMIQKECAAIRSSFREEDNTYRCRNVAKLLYMHMLGYPAHF 65
            ||.|.|||:|||.||.|||.||||.::.||||.|||:|||||:.:||||:|||||:|||||||||
  Fly    42 MPTPTRLRDLIRQIRAARTAAEERAVVNKECAYIRSTFREEDSVWRCRNIAKLLYIHMLGYPAHF 106

Mouse    66 GQLECLKLIASQKFTDKRIGYLGAMLLLDERQDVHLLMTNCIKNDLNHSTQFVQGLALCTLGCMG 130
            ||||||||.||.:||||||||||||||||||||||||:|||:|||||.|||||.||||||||.:.
  Fly   107 GQLECLKLTASTRFTDKRIGYLGAMLLLDERQDVHLLITNCLKNDLNSSTQFVVGLALCTLGAIA 171

Mouse   131 SSEMCRDLAGEVEKLLKTSNSYLRKKAALCAVHVIRKVPELMEMFLPATKNLLNEKNHGVLHTSV 195
            |.||.||||.|||:|:|:.|:|:||||.|||..|||:||||||:|||||::||:|||||:|.|.|
  Fly   172 SPEMARDLASEVERLMKSPNTYIRKKATLCAFRVIRRVPELMEIFLPATRSLLSEKNHGILITGV 236

Mouse   196 VLLTEMCERSPDMLAHFRK---NEKLVPQLVRILKNLIMSGYSPEHDVSGISDPFLQVRILRLLR 257
            .|:|||||.|.|.|.||:|   |.::||.|||||||||:.||||||||||:|||||||:||||||
  Fly   237 TLITEMCENSSDTLMHFKKDSGNREIVPNLVRILKNLILGGYSPEHDVSGVSDPFLQVKILRLLR 301

Mouse   258 ILGRNDDDSSEAMNDILAQVATNTETSKNVGNAILYETVLTIMDIKSESGLRVLAINILGRFLLN 322
            |||.||.|:|||||||||||||||||||||||.|||||||:||||:||.||||||:|||||||||
  Fly   302 ILGHNDPDASEAMNDILAQVATNTETSKNVGNTILYETVLSIMDIRSEGGLRVLAVNILGRFLLN 366

Mouse   323 NDKNIRYVALTSLLKTVQTDHNAVQRHRSTIVDCLKDLDVSIKRRAMELSFALVNGNNIRGMMKE 387
            :|||||||||.:||:||..|.:||||||:||::||||.||||:||||||||||:|..|||.|.||
  Fly   367 SDKNIRYVALNTLLRTVHADTSAVQRHRTTILECLKDPDVSIRRRAMELSFALINAQNIRTMTKE 431

Mouse   388 LLYFLDSCEPEFKADCASGIFLAAEKYAPSKRWHIDTIMRVLTTAGSYVRDDAVPNLIQLITNS- 451
            ||.||:..:.||||.|:||:.||||:|:|:.|||:||.:.||..||:|||||.|.:.|||:::|
  Fly   432 LLLFLEKADAEFKAQCSSGMILAAERYSPTTRWHLDTQLSVLIAAGNYVRDDVVSSTIQLVSSSP 496

Mouse   452 VEMHAYTVQRLYKAI-LGDY--SQQPLVQVAAWCIGEYGDLLVSGQCEEEEPIQVTEDEVLDILE 513
            |....|...|.:::: :.::  .:|||:|||.|.|||||||.:.| ..|:|..:.||.:::.:..
  Fly   497 VPEQTYITNRFWESLQVANHCEDKQPLLQVAVWAIGEYGDLFMYG-ANEDEFERPTESDLIAVYY 560

Mouse   514 SVLISNMSTSVTRGYALTAIMKLSTRFTCTVNRIKKVVSIYGSSIDVELQQRAVEYNALFKKYDH 578
            ..|.|...::.::.|||.::.|||||....|..|:.:::.:||.::|:||||.||:..||..|.|
  Fly   561 KFLTSAQVSTTSKQYALVSLAKLSTRLQQCVEEIQALITSFGSHLNVDLQQRGVEFTQLFGHYKH 625

Mouse   579 MRSALLERMPVMEKVTTNGPSEIVQTNGET--------EPAPLETKPPPSGPQPTS--------- 626
            :|..|||:||.|:      .|.|...|||:        .|..:|......|....|
  Fly   626 LRPPLLEKMPAMQ------ISRISSQNGESGGGSFDDNSPDVIENGVEGGGGGGHSLIESNMNTL 684

Mouse   627 --QANDLLDLLGGNDITP---------------------------VIP---------------TA 647
              ..|.||||||..|::.                           |.|               :|
  Fly   685 GDNTNILLDLLGSTDLSAGGAGDLVAATDLSNAVHKKNSRNANDVVAPVSNNQDLLDLLDLDLSA 749

Mouse   648 P----TSKPASAGG-----------------ELLDLLGDITLTGAPAAAPTPASVPQ-------- 683
            |    |..||..||                 .:.::||.:.|.|..:...:.||:|.
  Fly   750 PSSTTTGAPAGGGGGGGIVALVGDNNQSSAANMNNMLGGLDLGGFGSGLDSSASIPTNGNDLASM 814

Mouse   684 ---ISQPPF-------------LLDG--------LSSQPLFNDIA--PGIPSITAYSKNGLKIEF 722
               :..||.             |:||        |:.....|::.  |..|.:||..|:||.::.
  Fly   815 LGGLGAPPAASPSLAASAPVGNLIDGHAGSLLADLNPTAASNNVVVPPQGPRLTALDKDGLLVQL 879

Mouse   723 TFERSNTNPSVTVITIQASNSTELDMTDFVFQAAVPKTFQLQLLSPSSSVVPAFNTGTITQVIKV 787
            ...|.:....:.:.|...|::|   :..::.||||.::||||:|:||.||:|.  .|.|||.::|
  Fly   880 VSVRGSDCMRIYMTTTNNSDNT---LDQYLLQAAVQRSFQLQMLTPSGSVLPP--GGVITQEMRV 939

Mouse   788 LNPQKQQLRMRIKLTYNHKGSAMQDLAEVNNFPPQ 822
            :......||||:::.|...|....:..||:.||.|
  Fly   940 VATSNATLRMRLRIQYVLDGQQQVEQTEVSGFPEQ 974

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ap1g1	NP_033807.2	Adaptin_N	23..577	CDD:396262	364/560 (65%)
		HEAT repeat	142..163	CDD:293787	13/20 (65%)
		HEAT repeat	175..203	CDD:293787	19/27 (70%)
		HEAT repeat	246..276	CDD:293787	25/29 (86%)
		HEAT repeat	287..319	CDD:293787	26/31 (84%)
		Herpes_BLLF1	<593..>705	CDD:282904	40/227 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	596..630		9/52 (17%)
		Alpha_adaptinC2	712..820	CDD:197886	35/107 (33%)
AP-1gamma	NP_788891.2	Adaptin_N	68..624	CDD:396262	362/556 (65%)
		Alpha_adaptinC2	869..972	CDD:197886	35/107 (33%)