DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ap1b1 and AP-1-2beta

DIOPT Version :9

Sequence 1:	NP_001229972.1	Gene:	Ap1b1 / 11764	MGIID:	1096368	Length:	953	Species:	Mus musculus
Sequence 2:	NP_523415.1	Gene:	AP-1-2beta / 32987	FlyBaseID:	FBgn0010380	Length:	921	Species:	Drosophila melanogaster

Alignment Length:	956	Identity:	707/956 - (73%)
Similarity:	802/956 - (83%)	Gaps:	39/956 - (4%)

- Green bases have known domain annotations that are detailed below.

Mouse     1 MTDSKYFTTTKKGEIFELKAELNSDKKEKKKEAVKKVIASMTVGKDVSALFPDVVNCMQTDNLEL 65
            |||||||||||||||||||:|||:|||||||||||||||||||||||||||||||||||||||||
  Fly     1 MTDSKYFTTTKKGEIFELKSELNNDKKEKKKEAVKKVIASMTVGKDVSALFPDVVNCMQTDNLEL 65

Mouse    66 KKLVYLYLMNYAKSQPDMAIMAVNTFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCL 130
            ||||||||||||||||||||||||||||||||.||||||||||||||||||||||||||||||||
  Fly    66 KKLVYLYLMNYAKSQPDMAIMAVNTFVKDCEDSNPLIRALAVRTMGCIRVDKITEYLCEPLRKCL 130

Mouse   131 KDEDPYVRKTAAVCVAKLHDINAQLVEDQGFLDTLKDLISDSNPMVVANAVAALSEIAESHPSSN 195
            ||||||||||||||||||:||:|.:||||||||.||||:||||||||||||||||||.|:..|..
  Fly   131 KDEDPYVRKTAAVCVAKLYDISATMVEDQGFLDQLKDLLSDSNPMVVANAVAALSEINEASQSGQ 195

Mouse   196 -LLDLNPQSINKLLTALNECTEWGQIFILDCLANYMPKDDREAQSICERVTPRLSHANSAVVLSA 259
             |:::|..:||||||||||||||||:||||.||||.|||:|||||||||:||||:|||:||||||
  Fly   196 PLVEMNSVTINKLLTALNECTEWGQVFILDSLANYSPKDEREAQSICERITPRLAHANAAVVLSA 260

Mouse   260 VKVLMKFMEMLSKDLDYYATLLKKLAPPLVTLLSAEPELQYVALRNINLIVQKRPEILKHEMKVF 324
            ||||||.:||||.|.|:.|||.||||||||||||:|||:||||||||||||||||:|||||||||
  Fly   261 VKVLMKLLEMLSSDSDFCATLTKKLAPPLVTLLSSEPEVQYVALRNINLIVQKRPDILKHEMKVF 325

Mouse   325 FVKYNDPIYVKLEKLDIMIRLASQANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAE 389
            ||||||||||||||||||||||:|:||||||:|||||||||||||||||||||||||||||.|||
  Fly   326 FVKYNDPIYVKLEKLDIMIRLANQSNIAQVLSELKEYATEVDVDFVRKAVRAIGRCAIKVEPSAE 390

Mouse   390 RCVSTLLDLIQTKVNYVVQEAIVVIKDIFRKYPNKYESVIATLCENLDSLDEPEARAAMIWIVGE 454
            ||||||||||||||||||||||||||||||||||||||:|:|||||||:||||||||:|:||:||
  Fly   391 RCVSTLLDLIQTKVNYVVQEAIVVIKDIFRKYPNKYESIISTLCENLDTLDEPEARASMVWIIGE 455

Mouse   455 YAERIDNADELLESFLEGFHDESTQVQLQLLTAIVKLFLKKPTETQELVQQVLSLATQDSDNPDL 519
            ||||||||||||:||||||.||:.|||||||||:||||||:|::||||||.||||||||||||||
  Fly   456 YAERIDNADELLDSFLEGFQDENAQVQLQLLTAVVKLFLKRPSDTQELVQHVLSLATQDSDNPDL 520

Mouse   520 RDRGYIYWRLLSTDPVAAKEVVLAEKPLISEETDLIEPTLLDELICYIGTLASVYHKPPNAFVEG 584
            ||||:||||||||||.||||||||:||||||||||:||||||||||:|.:|||||||||.|||||
  Fly   521 RDRGFIYWRLLSTDPAAAKEVVLADKPLISEETDLLEPTLLDELICHISSLASVYHKPPTAFVEG 585

Mouse   585 GRGVVHKSLPPRTA-SSESTESPETAPAGAPAGDQPDVIPAQGDLLGDLLNLDL-GPPVSGPPLA 647
            ....|.||||.|.| |:...|..|.|     ||.:..|||.|..|:||||::|: .|.:...|.|
  Fly   586 RGAGVRKSLPNRAAGSAAGAEQAENA-----AGSEAMVIPNQESLIGDLLSMDINAPAMPSAPAA 645

Mouse   648 ASSVQMGAVDLLGGGLDSLMGDESEGIGDSNFGAPSASVAAAPAPARLGAPISSGLSDLFDLTSG 712
            .|:     |||||||||.|:|           |.|:   .|||..|      :|.|.|:|.|  |
  Fly   646 TSN-----VDLLGGGLDILLG-----------GPPA---EAAPGGA------TSLLGDIFGL--G 683

Mouse   713 VGTLSGSYVAPKAVWLPAMKAKGLEISGTFTRQAGSISMDLQLTNKALQVMTDFAIQFNRNSFGL 777
            ..|||.....||..||||.|.|||||.|||:|:.|.:.||:.|||||:|.||:||||.|:|||||
  Fly   684 GATLSVGVQIPKVTWLPAEKGKGLEIQGTFSRRNGEVFMDMTLTNKAMQPMTNFAIQLNKNSFGL 748

Mouse   778 APAAPLQVHVPLSPNQTVEISLPLNTVGSVLKMEPLNNLQVAVKNNIDVFYFSTLYPLHVLFVED 842
            .||:|:|. .||.|||::|:|:.|.|.|.:.:||||||||||||||||:|||:.|...:|||.||
  Fly   749 VPASPMQA-APLPPNQSIEVSMALGTNGPIQRMEPLNNLQVAVKNNIDIFYFACLVHGNVLFAED 812

Mouse   843 GKMDRQMFLATWKDIANENEAQFQIRDCPLNTEAASNKLQSSNIFTVAKRNVEGQDMLYQSLKLT 907
            |::|:::||.|||:|...||.|:.:......|:..::|:.::||||:||||||||||||||||||
  Fly   813 GQLDKRVFLNTWKEIPAANELQYTLSGVIGTTDGIASKMTTNNIFTIAKRNVEGQDMLYQSLKLT 877

Mouse   908 NGIWVLAELRIQPGNPSFTDLELSLKCRAPEVSQHVYQAYETILKN 953
            |.||||.||::|||||..|   ||||.|:.||:..::.|||.|:::
  Fly   878 NNIWVLLELKLQPGNPEAT---LSLKSRSVEVANIIFAAYEAIIRS 920

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ap1b1	NP_001229972.1	Adaptin_N	11..534	CDD:366724	464/523 (89%)
		HEAT repeat	51..75	CDD:293787	23/23 (100%)
		HEAT repeat	87..114	CDD:293787	25/26 (96%)
		HEAT repeat	121..151	CDD:293787	28/29 (97%)
		HEAT repeat	160..186	CDD:293787	23/25 (92%)
		HEAT repeat	197..228	CDD:293787	22/30 (73%)
		HEAT repeat	355..379	CDD:293787	22/23 (96%)
		HEAT repeat	391..419	CDD:293787	27/27 (100%)
		HEAT repeat	427..458	CDD:293787	24/30 (80%)
		HEAT repeat	464..490	CDD:293787	20/25 (80%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	584..621		14/37 (38%)
		Alpha_adaptinC2	730..830	CDD:197886	64/99 (65%)
		B2-adapt-app_C	839..952	CDD:198088	62/112 (55%)
AP-1-2beta	NP_523415.1	Adaptin_N	38..535	CDD:279882	439/496 (89%)
		HEAT repeat	51..75	CDD:293787	23/23 (100%)
		HEAT repeat	87..114	CDD:293787	25/26 (96%)
		Cnd1	99..269	CDD:289487	142/169 (84%)
		HEAT repeat	121..151	CDD:293787	28/29 (97%)
		HEAT repeat	160..186	CDD:293787	23/25 (92%)
		HEAT repeat	197..229	CDD:293787	23/31 (74%)
		HEAT repeat	393..417	CDD:293787	23/23 (100%)
		HEAT repeat	429..458	CDD:293787	22/28 (79%)
		HEAT repeat	465..495	CDD:293787	24/29 (83%)
		HEAT repeat	506..542	CDD:293787	32/35 (91%)
		Alpha_adaptinC2	703..799	CDD:197886	62/96 (65%)
		B2-adapt-app_C	809..919	CDD:198088	62/112 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850888
Domainoid	1	1.000	905	1.000	Domainoid score	I48
eggNOG	1	0.900	-	-		E1_COG5096
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H21972
Inparanoid	1	1.050	1350	1.000	Inparanoid score	I141
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53641
OrthoDB	1	1.010	-	-		D323029at2759
OrthoFinder	1	1.000	-	-		FOG0001621
OrthoInspector	1	1.000	-	-		otm43119
orthoMCL	1	0.900	-	-		OOG6_100684
Panther	1	1.100	-	-	LDO	PTHR11134
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2029
SonicParanoid	1	1.000	-	-		X1351
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.800