Protein Alignment TWIST2 and twi

DIOPT Version :10

• Sequence 1: NP_476527.1
• Gene: TWIST2 / 117581
• HGNCID: 20670
• Length: 160
• Species: Homo sapiens
• Sequence 2: NP_523816.2
• Gene: twi / 37655
• FlyBaseID: FBgn0003900
• Length: 490
• Species: Drosophila melanogaster
• Alignment Length: 213
• Identity: 74/213 - (34%)
• Similarity: 98/213 - (46%)
• Gaps: 67/213 - (31%)

Human    11 PVDSL-GTSEEELERQPKRFGRKRRYSKKS------------SEDGSP---------------TP 47
            |.:|| |::....:|....:.|....|..|            ::|||.               .|
  Fly   279 PANSLNGSAYSSSDRDDMEYARHNALSSVSDLNGGVMSPACLADDGSAGSLLDGSDAGGKAFRKP 343

Human    48 GKRGKKGSPSAQSFEELQSQRILANVRERQRTQSLNEAFAALRKIIPTLPSDKLSKIQTLKLAAR 112
            .:|.|:.....:..:|..:||::|||||||||||||:||.:|::|||||||||||||||||||.|
  Fly   344 RRRLKRKPSKTEETDEFSNQRVMANVRERQRTQSLNDAFKSLQQIIPTLPSDKLSKIQTLKLATR 408

Human   113 YIDFLYQVLQSDEMD-----------------------------------NKMTSCSYVAHERLS 142
            |||||.::|.|.::.                                   .|......:..|:||
  Fly   409 YIDFLCRMLSSSDISLLKALEAQGSPSAYGSASSLLSAAANGAEADLKCLRKANGAPIIPPEKLS 473

Human   143 YAFSVWRMEGAWSMSASH 160
            |.|.||||||    .|.|
  Fly   474 YLFGVWRMEG----DAQH 487

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TWIST2	NP_476527.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..63		14/79 (18%)
		bHLH_TS_TWIST2	51..132	CDD:381543	48/115 (42%)
twi	NP_523816.2	bHLH_TS_TWIST	363..421	CDD:381470	45/57 (79%)