Protein Alignment TWIST2 and cato

DIOPT Version :10

• Sequence 1: NP_476527.1
• Gene: TWIST2 / 117581
• HGNCID: 20670
• Length: 160
• Species: Homo sapiens
• Sequence 2: NP_477344.1
• Gene: cato / 36813
• FlyBaseID: FBgn0024249
• Length: 189
• Species: Drosophila melanogaster
• Alignment Length: 572
• Identity: 109/572 - (19%)
• Similarity: 191/572 - (33%)
• Gaps: 177/572 - (30%)

Human    26 QAELPRSRSKPYFQSGRSRTKRSWVWNQFFVLEEYMGSDPLYVGKLHSDVDKGDGSIKYILSGEG 90
            :|:.|.....|        |||:   .:...:|.:.......:..|...||..||..:...|..|
  Fly    16 EADAPSDMKSP--------TKRT---PKRKAVEAFQKESEELLKSLGVSVDLEDGRRRTRSSARG 69

Human    91 ASSIFIIDENTGDIHAT-------------KRLDREEQAYYT-LRAQALDRLTNKP------VEP 135
            |:      ..|..:.||             ||.::..:|..| .:.|:....::.|      .||
  Fly    70 AT------PTTAAVTATPPSKRARGASTTPKRTEKSAEAEATPSKQQSPSSKSSTPKKRAIQAEP 128

Human   136 ESEFVIKIQDINDNEPKFLDGPYT-----AGVPEMSPVGTSVVQVTATDA-----DDPTYGNSAR 190
            ....|:    ::...||    .||     |...:|....|:...|..:|:     :.......|.
  Fly   129 RKLVVL----VDSELPK----EYTRERMAAKTEKMDTTTTATEAVAKSDSVEMKKEQEEEEKKAA 185

Human   191 VVYSILQGQPYFSVEPKTGVIKTALPNM----------------------DREAKDQYLLVI--- 230
            ..      :|...||.|...:.|:....                      |:|.|::..:.:
  Fly   186 TT------EPAEKVEEKKEELATSTEEKQDEVEETKETPDTENKEEAKEEDKERKEEEEVTVAKD 244

Human   231 ----------QAKDMVGQNGGLSGTTSVTVTLTD-------VNDNPPRFPRRS-YQYNVPESLPV 277
                      .||:...|:...:...::.|...|       |||..|:....: .|.|..|:..|
  Fly   245 ADAAAPASDAPAKEETSQDKPPAEEKAMEVDTQDGGKAAEAVNDTHPKTESAAEAQSNEKETKDV 309

Human   278 ASVVARIKAADADIGVNAEMEY-KIVDGDGLGIFKISADKDT---QEGII--TIQKELDFEA-KT 335
            ......::    ::|..:|.|. |:|:.:    .:...:|.|   ||.::  .::||::.:| |.
  Fly   310 VMEDVSVQ----EVGKVSEKEVEKVVEKE----VEKEQEKVTEKEQEKVVEKEVEKEVEKDAEKE 366

Human   336 SYTLRIEAANRDADPRFLSLGPFSDTTTVKIIVEDVDEPPVFSSPLYPMEVSEATQVGHIIGTVA 400
            :..:.||:.....|...       ||||.|   ::|.||           .:.||..|......|
  Fly   367 AQKVEIESNGSVVDATV-------DTTTPK---KEVSEP-----------AAAATAGGVNSAESA 410

Human   401 AHDPDSSNSPVRYSIDRNTDLERYFNIDANSGVITTAKSLDRETNAVHNITVLAMESQNPSQVGR 465
            .|:....::|.:.|.|..|:     .:||:.   ..|:|.::.||            ..|.
  Fly   411 NHENAKESTPKKASDDEVTE-----TVDASK---APAESNEKVTN------------PEPK---- 451

Human   466 GYVAITILDINDN--APEFAMDYE--TTVCENAQPGQVIQKISAVDKDEPSN 513
                     :|::  ||....|.|  .|..::.....:..|...|:|.:.||
  Fly   452 ---------VNEDVAAPAIGPDTEQKQTETKDVTANNITTKDVDVEKVKASN 494

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TWIST2	NP_476527.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..63		7/36 (19%)
		bHLH_TS_TWIST2	51..132	CDD:381543	17/94 (18%)
cato	NP_477344.1	bHLH_TS_ATOH1_like	104..159	CDD:381436	12/62 (19%)