DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RacGAP84C and ARHGAP32

DIOPT Version :9

Sequence 1:	NP_476704.1	Gene:	RacGAP84C / 117503	FlyBaseID:	FBgn0045843	Length:	384	Species:	Drosophila melanogaster
Sequence 2:	NP_001364953.1	Gene:	ARHGAP32 / 9743	HGNCID:	17399	Length:	2101	Species:	Homo sapiens

Alignment Length:	164	Identity:	46/164 - (28%)
Similarity:	80/164 - (48%)	Gaps:	14/164 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   147 GC-LSDYAPRVAPMVPALIVHCVTEIEARGLQQEGLYRVSSTREKCKRLRRKLLRGKSTPHLGN- 209
            || |.::.......||.::..|...||..|: .:|:||:|......:|||.: ...:..|.|..
Human   385 GCDLGEHLLNSGFEVPQVLQSCTAFIERYGI-VDGIYRLSGVASNIQRLRHE-FDSEHVPDLTKE 447

  Fly   210 ---KDTHTLCCCVKDFLRQLVHPLI--PIYHR-RDFEEATRHEDRLAVEMAVYLAVLELHQAHRD 268
               :|.|::....|.:.|:|.:||:  .:|.: .|...|...|:||   :.::..:.:|...|..
Human   448 PYVQDIHSVGSLCKLYFRELPNPLLTYQLYEKFSDAVSAATDEERL---IKIHDVIQQLPPPHYR 509

  Fly   269 TLAYLMLHWQKIAESPAV-RMTVNNLAVIFAPTL 301
            ||.:||.|...:|:..:: .|...|||:::||.|
Human   510 TLEFLMRHLSLLADYCSITNMHAKNLAIVWAPNL 543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RacGAP84C	NP_476704.1	C1_1	87..139	CDD:278556
RacGAP84C	NP_476704.1	RhoGAP_MgcRacGAP	142..330	CDD:239847	46/164 (28%)
ARHGAP32	NP_001364953.1	PX_RICS	141..255	CDD:132831
		SH3_ARHGAP32_33	277..330	CDD:212769
		RhoGAP_CdGAP	382..576	CDD:239849	46/164 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	832..872
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	941..1052
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1117..1157
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1183..1271
		Interaction with GAB2. /evidence=ECO:0000269\|PubMed:12819203	1405..1725
		Interaction with FYN. /evidence=ECO:0000269\|PubMed:12788081	1699..2101
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1812..1910
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3564
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810