DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RacGAP84C and RACGAP1

DIOPT Version :9

Sequence 1:	NP_476704.1	Gene:	RacGAP84C / 117503	FlyBaseID:	FBgn0045843	Length:	384	Species:	Drosophila melanogaster
Sequence 2:	XP_024304726.1	Gene:	RACGAP1 / 29127	HGNCID:	9804	Length:	651	Species:	Homo sapiens

Alignment Length:	270	Identity:	111/270 - (41%)
Similarity:	155/270 - (57%)	Gaps:	14/270 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 QSHSGLLREHNFKIKSYYYNVGNCVHCRKRIRFAMASLRCRACPLRCHIGCCRQLTVNCIPQPQI 142
            ||:.| :|.|:|..|: .....:||.|.|||:|...||:||.|.:..|..|..:..:.||| ..|
Human   298 QSNGG-MRLHDFVSKT-VIKPESCVPCGKRIKFGKLSLKCRDCRVVSHPECRDRCPLPCIP-TLI 359

  Fly   143 GTK----RGCLSDYAPRVAPMVPALIVHCVTEIEARGLQQEGLYRVSSTREKCKRLRRKLLRGKS 203
            ||.    .|.|:|:..:.:||:|:::||||.|||.|||.:.||||:|......|.|:.|.||.|:
Human   360 GTPVKIGEGMLADFVSQTSPMIPSIVVHCVNEIEQRGLTETGLYRISGCDRTVKELKEKFLRVKT 424

  Fly   204 TPHLGN-KDTHTLCCCVKDFLRQLVHPLIPIYHRRDFEEATRHEDRLAVEMAVYLAVLELHQAHR 267
            .|.|.. .|.|.:|..:|||||.|..||:.....|.|.||....|......|:|.||.||.||:|
Human   425 VPLLSKVDDIHAICSLLKDFLRNLKEPLLTFRLNRAFMEAAEITDEDNSIAAMYQAVGELPQANR 489

  Fly   268 DTLAYLMLHWQKIAESPAVRMTVNNLAVIFAPTLFG------DLDLTLENVVTWQRVLKVLLLMP 326
            ||||:||:|.|::|:||..:|.|.|||.:|.||:..      |....|:::....:|::.||.:|
Human   490 DTLAFLMIHLQRVAQSPHTKMDVANLAKVFGPTIVAHAVPNPDPVTMLQDIKRQPKVVERLLSLP 554

  Fly   327 AGFWSQFLEV 336
            ..:||||:.|
Human   555 LEYWSQFMMV 564

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RacGAP84C	NP_476704.1	C1_1	87..139	CDD:278556	19/51 (37%)
RacGAP84C	NP_476704.1	RhoGAP_MgcRacGAP	142..330	CDD:239847	82/198 (41%)
RACGAP1	XP_024304726.1	SMC_N	32..>124	CDD:330553
		C1	306..354	CDD:237996	17/48 (35%)
		RhoGAP_MgcRacGAP	365..558	CDD:239847	79/192 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	143	1.000	Domainoid score	I4660
eggNOG	1	0.900	-	-		E1_KOG3564
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.928771	Normalized mean entropy	S4674
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D184774at33208
OrthoFinder	1	1.000	-	-		FOG0004815
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4412
SonicParanoid	1	1.000	-	-		X3396
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	8.760