DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RacGAP84C and cyk-4

DIOPT Version :9

Sequence 1:	NP_476704.1	Gene:	RacGAP84C / 117503	FlyBaseID:	FBgn0045843	Length:	384	Species:	Drosophila melanogaster
Sequence 2:	NP_499845.1	Gene:	cyk-4 / 176815	WormBaseID:	WBGene00000875	Length:	681	Species:	Caenorhabditis elegans

Alignment Length:	278	Identity:	90/278 - (32%)
Similarity:	131/278 - (47%)	Gaps:	34/278 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 LREHNFKIKSYYYNVGNCVHCRKRIRFAMASLRCRACPLRCHIGCCRQLTVNCIPQPQI------ 142
            :|.|.| |::....:..|..|...::.| .|::||.|....|..||.:|.:.|||:|:.
Worm   349 MRPHTF-IEAGIKAMRKCDKCATALKLA-TSMKCRDCHQVVHRSCCNKLHLPCIPRPKTMMTPKS 411

  Fly   143 ---GTKRGC----LSDYAPRVAPMVPALIVHCVTEIEARGLQQEGLYRVSSTREKCKRLRRKLLR 200
               |.|.|.    |.|:.....||:||.::|||..:|||||.|||:|||.........|..: ||
Worm   412 ALRGAKPGAGEFRLQDFCTSAKPMIPAAVIHCVVALEARGLTQEGIYRVPGQVRTVNVLLDE-LR 475

  Fly   201 GKSTPHLGNKDTHTLCCCVKDFLRQLVHPLIPIYHRRDFEEATR------HEDRLAVEMAVYLAV 259
            .|:.|::|..|...:...:|.|||.|..||||...|::...|..      ...|||:..    .:
Worm   476 SKTVPNVGLHDVEVITDTLKRFLRDLKDPLIPRTSRQELIVAANLYSTDPDNGRLALNR----VI 536

  Fly   260 LELHQAHRDTLAYLMLHWQK-IAESPAVRMTVNNLAVIFAPTLFG-------DLDLTLENVVTWQ 316
            .||.||:|||||||.:||:| ||:|...:|....:|.:.||.:.|       ...:...:.....
Worm   537 CELPQANRDTLAYLFIHWRKVIAQSSRNKMNCEAMARMVAPAVMGHPVKQSQSQAIAGRDATDCH 601

  Fly   317 RVLKVLLLMPAGFWSQFL 334
            |.:..|......:|.:||
Worm   602 RAMTALFEFDDVYWQRFL 619

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RacGAP84C	NP_476704.1	C1_1	87..139	CDD:278556	16/51 (31%)
RacGAP84C	NP_476704.1	RhoGAP_MgcRacGAP	142..330	CDD:239847	68/214 (32%)
cyk-4	NP_499845.1	DUF5098	33..>184	CDD:293628
		C1	352..402	CDD:294036	16/51 (31%)
		RhoGAP_MgcRacGAP	418..615	CDD:239847	66/201 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159175
Domainoid	1	1.000	94	1.000	Domainoid score	I4704
eggNOG	1	0.900	-	-		E1_KOG3564
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.928771	Normalized mean entropy	S4674
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D184774at33208
OrthoFinder	1	1.000	-	-		FOG0004815
OrthoInspector	1	1.000	-	-		otm14660
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4412
SonicParanoid	1	1.000	-	-		X3396
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.730