DRSC/TRiP Functional Genomics Resources

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Protein Alignment mthl11 and ADGRE5

DIOPT Version :9

Sequence 1:NP_731479.3 Gene:mthl11 / 117467 FlyBaseID:FBgn0045443 Length:532 Species:Drosophila melanogaster
Sequence 2:NP_510966.1 Gene:ADGRE5 / 976 HGNCID:1711 Length:835 Species:Homo sapiens


Alignment Length:291 Identity:61/291 - (20%)
Similarity:113/291 - (38%) Gaps:76/291 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   236 SVFFMVITIAAYLWLPKFRSLHGKCCNLYF---ICLAI---TFLLNVISLFGIFELKTPICYLTG 294
            |:|.:::.|..:|.:   |.:.|....::.   |||.:   .||..:.:..|...|:   |.|..
Human   558 SLFCLLLCILTFLLV---RPIQGSRTTIHLHLCICLFVGSTIFLAGIENEGGQVGLR---CRLVA 616

  Fly   295 YAGYFTVMATFLWLSVISFDVWRRFAMRKFQVFYKNKRSSFFNYNIIVWSSAGLLTCIIFLVDQF 359
            ...::..:|.|.|:|:...:::       |.|             :.|:...||.|..:.|:...
Human   617 GLLHYCFLAAFCWMSLEGLELY-------FLV-------------VRVFQGQGLSTRWLCLIGYG 661

  Fly   360 VETNLDNPYNPAVGVFS------------CWI-FTNG--WSATFYFYAPLAILIILNCASFFLTT 409
            |...:       |||.:            ||: |..|  ||    |..|:..:|:.| |..|:||
Human   662 VPLLI-------VGVSAAIYSKGYGRPRYCWLDFEQGFLWS----FLGPVTFIILCN-AVIFVTT 714

  Fly   410 RYIYVENKQNQKVLN-NSEPQKLSRNHANYRIYFRLFIIMGGSWFLEIIAFICEMENMWKPLIIL 473
            .:     |..||... |.:.:||.:..|..........::|.:|...:..|    ::....|..:
Human   715 VW-----KLTQKFSEINPDMKKLKKARALTITAIAQLFLLGCTWVFGLFIF----DDRSLVLTYV 770

  Fly   474 NDYINCSQGIIIFVATFCNHEMFRLIRKRIQ 504
            ...:||.||..:::       :..|:.|:::
Human   771 FTILNCLQGAFLYL-------LHCLLNKKVR 794

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mthl11NP_731479.3 Methuselah_N 26..204 CDD:310923
7tmB3_Methuselah-like 236..504 CDD:320167 61/289 (21%)
TM helix 2 258..280 CDD:320167 6/27 (22%)
TM helix 3 291..318 CDD:320167 5/26 (19%)
TM helix 4 335..355 CDD:320167 4/19 (21%)
TM helix 5 383..412 CDD:320167 11/30 (37%)
TM helix 6 433..460 CDD:320167 3/26 (12%)
TM helix 7 468..493 CDD:320167 5/24 (21%)
ADGRE5NP_510966.1 EGF_CA 64..99 CDD:284955
EGF_CA 116..>148 CDD:214542
EGF_CA 160..207 CDD:284955
EGF_CA 209..243 CDD:284955
GPS 493..536 CDD:280071
7tm_2 544..782 CDD:278432 59/270 (22%)
ProP 608..>785 CDD:223553 47/227 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 814..835
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4193
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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