DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mthl11 and adgre5b.3

DIOPT Version :9

Sequence 1:	NP_731479.3	Gene:	mthl11 / 117467	FlyBaseID:	FBgn0045443	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	XP_005160275.1	Gene:	adgre5b.3 / 792970	ZFINID:	ZDB-GENE-121214-275	Length:	756	Species:	Danio rerio

Alignment Length:	612	Identity:	106/612 - (17%)
Similarity:	221/612 - (36%)	Gaps:	175/612 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LLGILVIGVRSRDIPNCDFFDTVQLRESEKLCNGSYRYEDVVIPAKLTGKYDYEIDYDGDRVSV- 73
            |:.:|:...:|.:.|:.:.|...:|.|:  |||.:   :|::....:.         ||:.:||
Zfish   220 LMSLLMNSCKSLNDPHGEHFTAEKLLEN--LCNST---DDLLSEGNVA---------DGETLSVF 270

  Fly    74 ------------PKHIRGCVCKLKTCIRFC----CHHKKLMAGN--LCSQDVYENLTYEYT---- 116
                        |: ::..|.|::|...:.    ..::...:|:  |.:...:.|.::|..
Zfish   271 LDAVENSMRLIGPQ-LKDPVTKMETQNTYAEVAVTRNQTPPSGSVTLSTGSAHFNTSWETVVGKS 334

  Fly   117 ---------LDITQLNGS-------------VIKKHV---LNDMVVQQDLPLPCERHYS------ 150
                     :....:|.|             |.:|.:   ||..||...:..|..:|.|
Zfish   335 YPGFAFVALVSYKDMNSSSDLFNSMAREKSDVKEKQITYKLNSKVVTAVVSNPDTKHLSKPVTLI 399

  Fly   151 -------LDAETSTYD--MWSLYENGSLFRHFDQRYLSKQEFCLQPNPTSTGKNYSLIVAFNCIQ 206
                   .::|...|.  .||..|.|...|..:..:         .|.|.|..:.|.:.:|..:.
Zfish   400 FTHEEKRAESEGVAYSCVYWSESERGWSGRGCELAW---------SNSTHTACSCSHLSSFAVLM 455

  Fly   207 KPSMKMAYGRFECVRKSRLSNASIPVKFSSVFFMVITIAAYLWLPKFRSLHGKCCNLYF---ICL 268
              ::......||.|         :..:...|..::..|...|.....||:.|...:::.   :||
Zfish   456 --ALYPVEDTFELV---------VITRVGLVLSLICLILCILTFRFCRSIQGTRNSIHLHLSVCL 509

  Fly   269 AITFLLNVISLFGIFELKTPI-CYLTGYAGYFTVMATFLWLSVISFDVWRRFAMRKFQVFYKNKR 332
               |:.:::.|.||......: |.:.....:|..::.|.|:.:....::|...:    ||:...:
Zfish   510 ---FIADLVFLCGISSTHNQVACAIVAGLLHFFFLSAFCWMLLEGVQLYRMVVL----VFHTTLK 567

  Fly   333 SSF-----FNYNIIVWSSAGLLTCIIFLVDQFVETNLDNPYNPAVGVFSCWIFTNGWSATFYFYA 392
            ..:     :...:::.|.:.:.....:..|:                 .||:...|: ....|:.
Zfish   568 HLYMYAVGYGVPLVIVSISAIAVPKGYGTDR-----------------HCWLSLEGY-LILSFFI 614

  Fly   393 PLAILIILNCASFFLTTRYIYVENKQNQKVLNNSEPQKLSRNHANYRIYFRLFI--------IMG 449
            |:.|::|||...|.:|...:.::       .::..|. ||:.|.     .|.|:        ::|
Zfish   615 PVCIIVILNITVFIITVWKLALK-------FSSLNPD-LSKLHK-----IRSFLATAVAQLCVLG 666

  Fly   450 GSWFLEIIAFICEMENMWKPLIILNDYINCSQGIIIFVATFCNHEMFRLIRKRIQ---------- 504
            |||   :..|....:|..:.::.|...:|..||.:||:       |..|:.|:::
Zfish   667 GSW---VFGFFLFQKNGTEVMLYLFIILNSLQGALIFI-------MHCLLSKQVRVEYRSLFMRM 721

  Fly   505 --NRNITSLELTNTSRPVESEKMADVE 529
              |:......:::|.....|:|...::
Zfish   722 CSNKKKGDYSVSSTEPSHSSQKPLQID 748

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl11	NP_731479.3	Methuselah_N	26..204	CDD:310923	42/240 (18%)
		7tmB3_Methuselah-like	236..504	CDD:320167	53/284 (19%)
		TM helix 2	258..280	CDD:320167	4/24 (17%)
		TM helix 3	291..318	CDD:320167	3/26 (12%)
		TM helix 4	335..355	CDD:320167	1/24 (4%)
		TM helix 5	383..412	CDD:320167	9/28 (32%)
		TM helix 6	433..460	CDD:320167	7/34 (21%)
		TM helix 7	468..493	CDD:320167	6/24 (25%)
adgre5b.3	XP_005160275.1	EGF_CA	32..>62	CDD:214542
		EGF_CA	72..105	CDD:214542
		EGF_CA	<121..152	CDD:214542
		EGF_CA	154..188	CDD:214542
		GPS	416..460	CDD:197639	10/54 (19%)
		7tm_2	466..699	CDD:278432	49/282 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910