DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment mthl11 and Adgrf1

DIOPT Version :9

Sequence 1:NP_731479.3 Gene:mthl11 / 117467 FlyBaseID:FBgn0045443 Length:532 Species:Drosophila melanogaster
Sequence 2:XP_006525183.1 Gene:Adgrf1 / 77596 MGIID:1924846 Length:927 Species:Mus musculus


Alignment Length:519 Identity:103/519 - (19%)
Similarity:174/519 - (33%) Gaps:123/519 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    50 VVIPAKLTGKYDYEIDYDGDRVSVPKHIRGCVCKLK------TCIR---------FCCHHKKLMA 99
            :.:|...:||:   ||:.|..|:..:..||...:::      ..||         |...|.|.:.
Mouse   436 MALPLNFSGKF---IDWKGTPVTQIQSTRGYNYQMEMRQNASLPIRGHVFIEPDQFQKSHPKTII 497

  Fly   100 GNLCSQDVYENLTYEYTLDITQ-----LNGSVIKKHVLNDMVVQQDLPLPCERHYSLDAETSTYD 159
            .       ..:||:...|.|||     :||.||...:.|               ||:......:.
Mouse   498 S-------MASLTFGDILPITQRGNAWVNGPVISTLIQN---------------YSISEIFLNFS 540

  Fly   160 --MWSLYENGSLFRHFDQRYLSKQEFCLQPNPTSTGKNYSLIVAFNCIQKPSMKMAYGRFECVRK 222
              ..:|.:...:|..|.|...|... |...|.|..      .|...|....|..|....|     
Mouse   541 KIKGNLTQPRCVFWDFSQLQWSNAG-CQLVNETLD------TVLCRCSHLTSFSMLMSPF----- 593

  Fly   223 SRLSNASIP-VKFSSVFFMVITIAAYL---------WLPKFRSLHGKCCNLYFICLAITFLLNVI 277
              :.::.:| ||:.:...:.|:||:.:         |....||......|:..:.:|::.|:..:
Mouse   594 --VPSSVVPVVKWITYIGLSISIASLILCLIIESLFWKQTKRSQTSYTRNICLVNIAVSLLIADV 656

  Fly   278 SLFGIFELKTP------ICYLTGYAGYFTVMATFLWLSVISFDVWRRFAMRKFQVFYKNKRSSFF 336
             .|.|.....|      :|....:..:|..:|.|.|:.|:..    ..|.|...||:....::..
Mouse   657 -WFIIAATVDPSVSPSGVCVAAVFFTHFFYLAVFFWMLVLGI----LLAYRIILVFHHMALTTMM 716

  Fly   337 NYNIIVWSSAGLLTCIIFLVDQFVETNLDNPYNPAVGVFSCWIFTNGWS----ATFYFYAPLAIL 397
            .....:.....||..||.|.       :..|.|.......||:   .||    ....|..|...:
Mouse   717 AIGFCLGYGCPLLISIITLA-------VTQPSNSYKRNDVCWL---NWSDKSKPLLAFVVPALTI 771

  Fly   398 IILNCASFFLTTRYIY---VENKQNQKVLNNSEPQKLSRNHANYRIYFRLFIIMGGSWFLEIIAF 459
            :.:|.....|..|.::   |..:.||.  :.:...::.::      ...|..::|.:|...|...
Mouse   772 VAVNLVVVLLVLRKLWRPAVGERLNQD--DKATAIRMGKS------LLVLTPLLGLTWGFGIGTM 828

  Fly   460 ICEMENMWKPLIILNDYINCSQGIIIFVATFCNHEMFRL-----IRKRIQNRNITSLELTNTSR 518
            .......|..|..|   :|..||..|    ||    |.:     :|:.:.|:..|......||:
Mouse   829 ANSHNLAWHVLFAL---LNAFQGFFI----FC----FGILLDTKLRQLLSNKLTTLSSWKQTSK 881

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mthl11NP_731479.3 Methuselah_N 26..204 CDD:310923 36/175 (21%)
7tmB3_Methuselah-like 236..504 CDD:320167 56/294 (19%)
TM helix 2 258..280 CDD:320167 3/21 (14%)
TM helix 3 291..318 CDD:320167 5/26 (19%)
TM helix 4 335..355 CDD:320167 4/19 (21%)
TM helix 5 383..412 CDD:320167 7/32 (22%)
TM helix 6 433..460 CDD:320167 4/26 (15%)
TM helix 7 468..493 CDD:320167 8/24 (33%)
Adgrf1XP_006525183.1 SEA 172..258 CDD:366610
GPS 549..590 CDD:197639 11/47 (23%)
7tm_GPCRs 603..866 CDD:391938 57/296 (19%)
TM helix 1 603..626 CDD:341315 4/22 (18%)
TM helix 2 641..663 CDD:341315 5/22 (23%)
TM helix 3 675..702 CDD:341315 6/30 (20%)
TM helix 4 716..736 CDD:341315 4/19 (21%)
TM helix 5 757..786 CDD:341315 5/28 (18%)
TM helix 6 803..829 CDD:341315 4/31 (13%)
TM helix 7 834..859 CDD:341315 10/35 (29%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4193
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

Return to query results.
Submit another query.