DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl11 and Adgrd1

DIOPT Version :9

Sequence 1:	NP_731479.3	Gene:	mthl11 / 117467	FlyBaseID:	FBgn0045443	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	XP_001070157.3	Gene:	Adgrd1 / 689257	RGDID:	1594795	Length:	903	Species:	Rattus norvegicus

Alignment Length:	348	Identity:	70/348 - (20%)
Similarity:	136/348 - (39%)	Gaps:	75/348 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   212 MAYGRFECVRKSRLSNASI-----PVKFSSVFFMVITIAAYLWLPKFRSLHGKCCNLYFICLA-- 269
            :.|....|   :.|:|.:|     |:|.:....:.::..:|:.           |:|..:|||
  Rat   563 LTYSVCHC---THLTNFAILMQVVPLKLTLGHQVALSSISYVG-----------CSLSVLCLAAT 613

  Fly   270 -ITF-LLNVISL-------------FGI------------FELKTPICYLTGYAGYFTVMATFLW 307
             :|| :|:.:|.             |.:            .|..|..|.:.....::..:..|.|
  Rat   614 LVTFAVLSSVSTIRNQRYHIHANLSFAVLVAQVLLLISFSMEPGTVPCQVLAVLLHYFFLTAFAW 678

  Fly   308 LSVISFDVWRRFAMRKFQVFYKNKRSSFFNYNIIVWSSAGLLTCIIFLVDQFVETNLDNPYNPAV 372
            :.|....::...    .:||........:.|. |.| ...||.|||     .|.:::|: |...
  Rat   679 MLVEGLHLYSMV----IKVFGSEDSKHLYYYG-IGW-GCPLLICII-----SVSSSMDS-YGTG- 730

  Fly   373 GVFSCWIFTNGWSATFYFYAPLAILIILNCASFFLTTRYIYVENKQNQKVLNNSEPQKLSRNHAN 437
              .|||:.... .|.:.|..|..::|::|.......||.|...:..:.|:..:....||:.
  Rat   731 --DSCWLSVES-GAIWAFVGPALLVIVVNIVILVAVTRVISHISTDSYKIHGDPSAFKLTA---- 788

  Fly   438 YRIYFRLFIIMGGSWFLEIIAFICEMENMWKPLIILNDYINCSQGIIIFV-ATFCNHEMFRLIRK 501
             :....|..|:|.||...::| :.:...:::.:..:   :|.|||:.||: ....|.|:....:.
  Rat   789 -KAVAVLLPILGTSWVFGVLA-VSDRALVFQYMFAI---LNSSQGLFIFLFHCLLNSEVRAAFKH 848

  Fly   502 RIQNRNITSLEL-TNTSRPVESE 523
            :::..::||... |..::|..|:
  Rat   849 KMKVWSLTSSSAHTANTKPSSSD 871

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl11	NP_731479.3	Methuselah_N	26..204	CDD:310923
		7tmB3_Methuselah-like	236..504	CDD:320167	58/297 (20%)
		TM helix 2	258..280	CDD:320167	9/38 (24%)
		TM helix 3	291..318	CDD:320167	3/26 (12%)
		TM helix 4	335..355	CDD:320167	8/19 (42%)
		TM helix 5	383..412	CDD:320167	7/28 (25%)
		TM helix 6	433..460	CDD:320167	6/26 (23%)
		TM helix 7	468..493	CDD:320167	6/25 (24%)
Adgrd1	XP_001070157.3	LamG	<173..273	CDD:304605
		GPS	539..579	CDD:280071	4/18 (22%)
		7tm_4	595..831	CDD:304433	54/271 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810