DRSC/TRiP Functional Genomics Resources

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Protein Alignment mthl11 and adgrl1a

DIOPT Version :9

Sequence 1:NP_731479.3 Gene:mthl11 / 117467 FlyBaseID:FBgn0045443 Length:532 Species:Drosophila melanogaster
Sequence 2:XP_021330394.1 Gene:adgrl1a / 562531 ZFINID:ZDB-GENE-131127-267 Length:1524 Species:Danio rerio


Alignment Length:499 Identity:96/499 - (19%)
Similarity:157/499 - (31%) Gaps:181/499 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   102 LCSQDVYENLTYEYTLDITQLNGSVIKKHVLNDMVVQQDLPLPCE--RHYSLDAETSTYDMWSLY 164
            |.:.::|.|...::..::.      ::..|||.....|||..|..  ...|:....||:..:|  
Zfish   657 LLANNMYNNHFSDHAANVD------LEVRVLNTETDSQDLSFPQSGPSDSSIQLSASTFKQYS-- 713

  Fly   165 ENGSLFRHFDQRYLSKQEFCLQPNPTSTGKNYSLIVAFNCIQKPSMKMAYGRFECVRKSRLSNAS 229
            .||.:          |..|.|..|   .|   |.:...|...|..|:...|.......|.:..||
Zfish   714 RNGQV----------KVVFVLYKN---LG---SFLSTENATVKMEMEAGIGGRGLAVNSHVIAAS 762

  Fly   230 IPVKFSSVFF---MVITIA-----------AYLWLPKFRSLHGK-------------------CC 261
            |..:.|.||.   :|.|:.           ...|....||:.|:                   |.
Zfish   763 INKESSRVFLTEPVVFTLRHLQLENHFSPNCSFWNYSERSMTGQWSSQGCRLIETNSTHTTCSCS 827

  Fly   262 NL---------------------------------YFICLAI----------------------- 270
            :|                                 ..:||||                       
Zfish   828 HLTNFAVLMVHHEPDYPGRMHELILFVITWVGIVISLVCLAICISTFCFLRGLQTDRNTIHKNLC 892

  Fly   271 --TFLLNVISLFGI----FELKTPICYLTGYAG--YFTVMATFLWLSVISFDVWRRFAMRKFQVF 327
              .|:..::.|.||    :.:..||     :||  :|..:|.|.|:.:....:: ...:..|:..
Zfish   893 INLFIAELLFLIGIDKTQYHIACPI-----FAGLLHFFFLAAFSWMCLEGIQLY-LMLVEVFESE 951

  Fly   328 YKNKRSSFFNYNIIVWSSAGLLTCIIFLVDQFVETNLDNPYNPAVGVFSCWIFTNG---WSATFY 389
            |..|:    .|.:..:....|:..|...:|          |.......:||:..:.   ||    
Zfish   952 YSRKK----YYYLCGYCFPALVVGISAAID----------YRSYGTKKACWLRVDNYFIWS---- 998

  Fly   390 FYAPLAILIILNCASFFLTTRYIYVENKQNQKVLNNSEPQKLSRNHANYRIYFRLFIIMGGSWFL 454
            |..|::.:|:||.....:|.          .|::.||...|...:        ||..|.  ||.|
Zfish   999 FIGPVSFIIMLNLVFLMITL----------HKMIRNSSALKPDSS--------RLDNIK--SWAL 1043

  Fly   455 EIIAFICEMENMWK-PLIILND------YI----NCSQGIIIFV 487
            ..||.:..:...|. .|:.:|:      |:    |..||:.||:
Zfish  1044 GAIALLFLLGLTWAFGLLFINENTVIMAYLFTTFNAFQGMFIFI 1087

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mthl11NP_731479.3 Methuselah_N 26..204 CDD:310923 22/103 (21%)
7tmB3_Methuselah-like 236..504 CDD:320167 65/363 (18%)
TM helix 2 258..280 CDD:320167 8/98 (8%)
TM helix 3 291..318 CDD:320167 6/28 (21%)
TM helix 4 335..355 CDD:320167 3/19 (16%)
TM helix 5 383..412 CDD:320167 8/31 (26%)
TM helix 6 433..460 CDD:320167 8/26 (31%)
TM helix 7 468..493 CDD:320167 8/31 (26%)
adgrl1aXP_021330394.1 Gal_Lectin 48..128 CDD:307994
OLF 142..398 CDD:321983
HormR 474..535 CDD:214468
GAIN 545..765 CDD:318649 30/131 (23%)
GPS 789..836 CDD:197639 6/46 (13%)
7tmB2_Latrophilin-1 849..1106 CDD:320673 55/283 (19%)
TM helix 1 851..876 CDD:320673 4/24 (17%)
TM helix 2 885..907 CDD:320673 3/21 (14%)
TM helix 3 916..943 CDD:320673 8/32 (25%)
TM helix 4 955..975 CDD:320673 4/23 (17%)
TM helix 5 992..1021 CDD:320673 8/42 (19%)
TM helix 6 1037..1064 CDD:320673 8/28 (29%)
TM helix 7 1068..1093 CDD:320673 6/20 (30%)
Latrophilin 1105..1524 CDD:308136
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4193
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.810

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