DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl11 and adgrg6

DIOPT Version :9

Sequence 1:	NP_731479.3	Gene:	mthl11 / 117467	FlyBaseID:	FBgn0045443	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	NP_001356058.1	Gene:	adgrg6 / 561970	ZFINID:	ZDB-GENE-041014-357	Length:	1208	Species:	Danio rerio

Alignment Length:	326	Identity:	73/326 - (22%)
Similarity:	122/326 - (37%)	Gaps:	67/326 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   236 SVFFMVITIAAYLWLPKFRS------LHGKCCNLYFICLAITFLLNVISLFGIFELKTPICYLTG 294
            |..|...|:..|:...|.|.      |.....:|.|  |.:.|||:  .....:|:| .:|....
Zfish   830 SAIFSAATLLTYIAFEKLRRDYPSKILMNLSTSLLF--LNMVFLLD--GWLASYEIK-ELCVTVA 889

  Fly   295 YAGYFTVMATFLWLSVISFDVWRRFAMRKFQVFYKNKRSSFFNYNIIVWSSAGLLTCIIFLVDQF 359
            ...:|.::.:|.|:.:.|..::  .|:.|  ||....|.....:.|:.|.....:..|:..|.:
Zfish   890 VFLHFFLLTSFTWMGLESIHMY--IALVK--VFNTYIRRYILKFCIVGWGVPAAIVGIVLAVSK- 949

  Fly   360 VETNLDNPY-----NPAVGVFSCWIFTNGWSATFYF--YAPLAILIILNCASFFLTTRYIYVEN- 416
             ::...|.|     ......| |||..   ...||.  .|..:|:.::|.|.|.:....|...|
Zfish   950 -DSYGKNYYGKGKDGQGTSEF-CWILN---PVVFYVTCVAYFSIIFLMNVAMFIVVMIQICGRNG 1009

  Fly   417 KQNQKVLNNSEPQKLSRNHANYRIYFRLFIIMGGSWFLEIIAFICEMENMWKPLIILNDYI---- 477
            |::.:.|.    :.:.|   |.|....|..::|.:|.....|        |.|:.:...|:
Zfish  1010 KRSNRTLR----EDILR---NLRSVVSLTFLLGMTWGFAFFA--------WGPVSLAFMYLFTIF 1059

  Fly   478 NCSQGIIIFVATFCNHEMFRLIRK-----------RIQNRNITSLELTNTSRPVESEKMADVELG 531
            |..||:.|||......|.   ::|           |:.:.:..|...||.::.|.|:     .||
Zfish  1060 NSLQGLFIFVFHCALKEN---VQKQWRRYLCCGKLRLADNSDWSKTATNNTKKVSSD-----NLG 1116

  Fly   532 K 532
            |
Zfish  1117 K 1117

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl11	NP_731479.3	Methuselah_N	26..204	CDD:310923
		7tmB3_Methuselah-like	236..504	CDD:320167	65/296 (22%)
		TM helix 2	258..280	CDD:320167	6/21 (29%)
		TM helix 3	291..318	CDD:320167	4/26 (15%)
		TM helix 4	335..355	CDD:320167	3/19 (16%)
		TM helix 5	383..412	CDD:320167	7/30 (23%)
		TM helix 6	433..460	CDD:320167	7/26 (27%)
		TM helix 7	468..493	CDD:320167	8/28 (29%)
adgrg6	NP_001356058.1	CUB	41..146	CDD:278839
		LamG	153..336	CDD:354964
		GPS	756..801	CDD:334696
		7tmB2_GPR126	816..1086	CDD:320662	64/288 (22%)
		TM helix 1	818..843	CDD:320662	4/12 (33%)
		TM helix 2	853..875	CDD:320662	7/25 (28%)
		TM helix 3	886..913	CDD:320662	4/28 (14%)
		TM helix 4	928..944	CDD:320662	2/15 (13%)
		TM helix 5	975..998	CDD:320662	6/22 (27%)
		TM helix 6	1021..1046	CDD:320662	7/35 (20%)
		TM helix 7	1050..1075	CDD:320662	7/24 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810