DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl11 and Adgrg3

DIOPT Version :9

Sequence 1:	NP_731479.3	Gene:	mthl11 / 117467	FlyBaseID:	FBgn0045443	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	NP_766624.3	Gene:	Adgrg3 / 54672	MGIID:	1859670	Length:	542	Species:	Mus musculus

Alignment Length:	467	Identity:	87/467 - (18%)
Similarity:	163/467 - (34%)	Gaps:	124/467 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 DYDGDRVSVPKHIRGCVCKLKTCIRFCCHHKKLMAGNLCSQDVYENLTYEYTLDITQLNGSVIKK 129
            |...|.|.:||.:.|.:...::.:|.......:.|||:          ::....:.....||:..
Mouse   123 DEPADGVRLPKSLFGALPGNRSAVRLAITVLDIGAGNV----------FKGPKLLEDKGSSVLNN 177

  Fly   130 HVLNDMVVQQ---DLPLPCERHYSLDAETS----TYDMWSLYENGSLFRHFDQRYLSKQEFCLQP 187
            .::...|.|.   .|..|.|..:|.:.:..    |...|.:.:.     .:|....|     ..|
Mouse   178 RMVGLSVGQMHATGLSEPVEITFSHERQPPNVILTCVFWDMAKG-----DWDSHGCS-----TVP 232

  Fly   188 NPTSTGKNYSLIVAFNCIQKPSMKMAYGRFECVRKSRLSNASIPVKFSSVFFMVITIAAYL---- 248
            ....|......:..|..:.:|.:.:|..:    ..:|:|.|...|   |:.|:..|:..|:
Mouse   233 GDGRTVCRCDHLTFFALLLRPILDLATAQ----TLTRISQAGSAV---SMIFLAFTMVLYVAFRF 290

  Fly   249 WLPKFRS-----LHGKCCNLYFICLAITFLLNVISLFGIFELKTPI-CYLTGYAGYFTVMATFLW 307
            .|.:|:|     :| ...::....|.:|||:||    |......|. |::.....::.::..|.|
Mouse   291 SLQRFKSEDAPKIH-MALSISLFLLNLTFLINV----GSSSQGPPASCWVRAAIFHYFLLCVFTW 350

  Fly   308 LSVISFDVWRRFAMRKFQVFYKNKRSSFFNYNIIVWSSAGLLTCIIFLVDQFVETNLDNPYNPAV 372
            :.:.:|.:: ..|:|.|..::.:   .|...:::.|   ||...::      :.....|.|
Mouse   351 MGLEAFHLY-LLAIRVFNTYFGH---YFLKLSLLAW---GLPVLVV------IGAGSSNSY---- 398

  Fly   373 GVFS------------CWI--------FTNGW-SATFYFYAPLAILIILNCASFFLTTRYIYVEN 416
            ||::            ||.        ..:|: ..||.|.|.:..|:    |....|...:....
Mouse   399 GVYTIRDQENRTSLELCWFQKEPALYATVHGYFLVTFLFGAVVLALV----AWKIFTLPSVTAGK 459

  Fly   417 KQN---QKVLNNSEPQKLSRNHANYRIYFRLFIIMGGSWFLEIIAFICEMENMWKPLIILNDYI- 477
            .|.   :.||.                ...|..::|.:|.|.::.          ||.:...|:
Mouse   460 GQGPTWKSVLT----------------VLGLSSLVGMTWGLAVLT----------PLGLSTIYVF 498

  Fly   478 ---NCSQGIIIF 486
               |..||:.||
Mouse   499 TLLNSLQGLFIF 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl11	NP_731479.3	Methuselah_N	26..204	CDD:310923	25/145 (17%)
		7tmB3_Methuselah-like	236..504	CDD:320167	56/289 (19%)
		TM helix 2	258..280	CDD:320167	6/21 (29%)
		TM helix 3	291..318	CDD:320167	3/26 (12%)
		TM helix 4	335..355	CDD:320167	4/19 (21%)
		TM helix 5	383..412	CDD:320167	8/29 (28%)
		TM helix 6	433..460	CDD:320167	4/26 (15%)
		TM helix 7	468..493	CDD:320167	8/23 (35%)
Adgrg3	NP_766624.3	GPS	211..250	CDD:280071	7/48 (15%)
Adgrg3	NP_766624.3	7tm_4	262..509	CDD:304433	58/301 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810