DRSC/TRiP Functional Genomics Resources

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Protein Alignment mthl11 and Adgre4

DIOPT Version :9

Sequence 1:NP_731479.3 Gene:mthl11 / 117467 FlyBaseID:FBgn0045443 Length:532 Species:Drosophila melanogaster
Sequence 2:NP_631877.2 Gene:Adgre4 / 52614 MGIID:1196464 Length:689 Species:Mus musculus


Alignment Length:567 Identity:111/567 - (19%)
Similarity:201/567 - (35%) Gaps:145/567 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 RVEYLLLGILVIGVRSRDIPNCDFFDTVQLRESEKLCNGSYRYEDVVIPAKLTGKYDYEIDYDGD 69
            :||:.:|.      .:.|||..|....:.:....|.|......|        .|....::|... 
Mouse   163 KVEHHILN------ENSDIPKKDENPLLDIVYETKRCKTMTLLE--------AGNNTMKVDCTS- 212

  Fly    70 RVSVPKHIRGCVCKLKTCIRFCCHHKKLMAGNLCSQDVYENLTYEYTLDITQLNGSVIKKHVLND 134
              ...:|..|.    :|.:.|.. :|.|  |||.:...:.|   |.......||..::...:.::
Mouse   213 --GFKEHNSGG----ETAVAFIA-YKSL--GNLLNGSFFSN---EEGFQEVTLNSHIVSGAIRSE 265

  Fly   135 M--VVQQDLPLPCERHYSLDAETSTYDM-WSLYENGSLFRHFDQRYLSKQEFCLQPNPTSTGKNY 196
            :  |:.:.:.|..:....:|:......: |...|.|..:         ..:.|   :...|..:|
Mouse   266 VKPVLSEPVLLTLQNIQPIDSRAEHLCVHWEGSEEGGSW---------STKGC---SHVYTNNSY 318

  Fly   197 SLIVAFNCIQKPSMKMAYGRFECVRKSRLSNASIPVKFSSVFFMVITIAAYLWLPKFRSLHGKCC 261
            ::...|: :...::.||....|....|.||  .|.....|:..:.:.:||..:| ..|.:.....
Mouse   319 TICKCFH-LSSFAVLMALPHEEDGVLSALS--VITYVGLSLSLLCLFLAAITFL-LCRPIQNTST 379

  Fly   262 NLYF---ICLAITFLLNVISLFGIFELKTPI-CYLTGYAGYFTVMATFLW--------------L 308
            .|:.   |||   ||.:::.|.||...|..: |.:.....::..:|:|:|              |
Mouse   380 TLHLQLSICL---FLADLLFLTGINRTKPKVLCSIIAGMLHYLYLASFMWMFLEGLHLFLTVSNL 441

  Fly   309 SVISFDVWRRFAMRKFQVFYKNKRSSFFNYNIIVWSSAGLLTCIIFLVDQFVETNLDNPYNPAVG 373
            .|.::....||..|             |.|.:    ..||...|:                 ||.
Mouse   442 KVANYSNSGRFKKR-------------FMYPV----GYGLPAFIV-----------------AVS 472

  Fly   374 VFS----------CWIFTNG---WSATFYFYAPLAILIILNCASFFLTTRYIYVENKQNQKVLNN 425
            ..:          ||:..:.   ||    |..|.|.:|::|...:||....:..:.....|.::.
Mouse   473 AIAGHKNYGTHNHCWLSLHRGFIWS----FLGPAAAIILINLVFYFLIIWILRSKLSSLNKEVST 533

  Fly   426 SEPQKLSRNHANYRIYFRLFIIMGGSWFLEIIAFICEMENMWKPLIILNDY----INCSQGIIIF 486
            .:..|:    ..::...:|| ::|.||.:.:..||    .:.|.:.::..|    ||..||::||
Mouse   534 LQDTKV----MTFKAIVQLF-VLGCSWGIGLFIFI----EVGKTVRLIVAYLFTIINVLQGVLIF 589

  Fly   487 -VATFCNHEM-------FRLIRKRIQNRNITSLELTNTSRPVESEKM 525
             |....|.::       |..:||.:::      |.|..|......||
Mouse   590 MVHCLLNRQVRMEYKKWFHRLRKEVES------ESTEVSHSTTHTKM 630

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mthl11NP_731479.3 Methuselah_N 26..204 CDD:310923 29/180 (16%)
7tmB3_Methuselah-like 236..504 CDD:320167 64/310 (21%)
TM helix 2 258..280 CDD:320167 6/24 (25%)
TM helix 3 291..318 CDD:320167 5/40 (13%)
TM helix 4 335..355 CDD:320167 5/19 (26%)
TM helix 5 383..412 CDD:320167 9/31 (29%)
TM helix 6 433..460 CDD:320167 5/26 (19%)
TM helix 7 468..493 CDD:320167 9/29 (31%)
Adgre4NP_631877.2 EGF_CA 77..>105 CDD:214542
GAIN <214..262 CDD:293098 13/57 (23%)
GPS 290..332 CDD:280071 7/54 (13%)
7tm_4 343..588 CDD:304433 61/297 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4193
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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