Protein Alignment mthl11 and adgrl4

DIOPT Version :10

• Sequence 1: NP_731479.3
• Gene: mthl11 / 117467
• FlyBaseID: FBgn0045443
• Length: 532
• Species: Drosophila melanogaster
• Sequence 2: NP_998532.3
• Gene: adgrl4 / 406676
• ZFINID: ZDB-GENE-040426-2689
• Length: 738
• Species: Danio rerio
• Alignment Length: 494
• Identity: 98/494 - (19%)
• Similarity: 167/494 - (33%)
• Gaps: 133/494 - (26%)

  Fly    59 KYDYEIDYDGDRVSV-PKHIRGCVCKLKTCIRFCCHHKKLMAGNLC----SQDVYENLTYEYTLD 118
            |:....:..|:.:|: .|..|.......|.:.|..:|.   .|:|.    ...|.:...|....:
Zfish   316 KHPLSANIQGNSISLSTKKARHANNNGSTSVVFLIYHS---IGDLLKPADDPGVADYSRYAAAGE 377

  Fly   119 ITQLNGSVIKKHVLNDMVVQQDLPL-----PCERHYSLDA---ET---------STYDMWSLYEN 166
            || :|..||...:.|    |:.|||     ..:....:|.   ||         |....|||
Zfish   378 IT-VNSPVIAAAISN----QKTLPLNDVTFTLKHTQEIDPARDETKCAFWEYSPSMMGHWSL--- 434

  Fly   167 GSLFRHFDQRYLSKQEFCLQP--NPTSTGKNYSLIVAFNCIQKPSMKMAYGRFECVRKSRLSNAS 229
                           :.|::.  |.|.|..:.:.:..|..:...:.......:..:  :|::...
Zfish   435 ---------------DGCIRTRVNTTHTSCSCNHLTHFAILMSSARANLLAHYNVL--TRITQLG 482

  Fly   230 IPVKFSSVFFMVITIAAYLWLPKFRSLHGK--------CCNLYFICLAITFLLNVISLFGIFEL- 285
            :.:....:...:.|    .|.  ||.:...        ||:|        |:...|.|.||.:.
Zfish   483 MVISLICLSMCIFT----FWF--FRDIQNTRTTIHKNLCCSL--------FMAQFIFLIGINKSA 533

  Fly   286 -KTPICYLTGYAGYFTVMATFLWLSVISFDVWRRFAMRKFQVFYKNKRSSFFNYNIIVWSSAGLL 349
             |.....:.|...|| .:|.|.|:.:....::    :....|.| ||.....|:....:.|..::
Zfish   534 HKWFCSLIAGLLHYF-FLAAFAWMCIEGIHLY----LIVVGVIY-NKGFLHRNFYAFGYGSPAVV 592

  Fly   350 TCIIFLVDQFVETNLDNPYNPAVGVFSCWIFTNG---WSATFYFYAPLAILIILNCASFFLTTRY 411
            ..|        ...|...|.....|  ||:.|..   ||    |..|..::|::|..:|.:   .
Zfish   593 VAI--------SATLGYKYYGTSSV--CWLSTENNFIWS----FIGPAILIILVNLLAFAV---I 640

  Fly   412 IYVENKQNQKVLNNSEPQKLSRNH-ANYRIYFR----LFIIMGGSWFLEIIAFICEMENMWKPLI 471
            ||       ||..::..:|...:| .|.|...|    |..::|.:|...::..:.|        .
Zfish   641 IY-------KVYRHTAVKKPEISHYENIRSCARGAIALLFVLGVTWAFGVMYILYE--------T 690

  Fly   472 ILNDYI----NCSQGIIIFVATFC------NHEMFRLIR 500
            .|..|:    |..||:.||: ..|      ..|.:||.:
Zfish   691 TLTAYLFTFANVFQGMFIFI-FLCVLSRRIQEEYYRLFK 728

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl11	NP_731479.3	Methuselah_N	26..204	CDD:429053	34/168 (20%)
		7tmB3_Methuselah-like	236..504	CDD:410632	63/293 (22%)
		TM helix 2	258..280	CDD:410632	5/29 (17%)
		TM helix 3	291..318	CDD:410632	6/26 (23%)
		TM helix 4	335..355	CDD:410632	3/19 (16%)
		TM helix 5	383..412	CDD:410632	7/31 (23%)
		TM helix 6	433..460	CDD:410632	7/31 (23%)
		TM helix 7	468..493	CDD:410632	8/34 (24%)
adgrl4	NP_998532.3	None