DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl11 and mthl6

DIOPT Version :9

Sequence 1:	NP_731479.3	Gene:	mthl11 / 117467	FlyBaseID:	FBgn0045443	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	NP_788473.1	Gene:	mthl6 / 38839	FlyBaseID:	FBgn0035789	Length:	480	Species:	Drosophila melanogaster

Alignment Length:	513	Identity:	170/513 - (33%)
Similarity:	261/513 - (50%)	Gaps:	65/513 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLLGILVIGVRSRD---IPNCDFFDTVQLRESEKLCNGSYRYEDVVIPAKLTGKYDYEIDYDGDR 70
            :|..|||..:.|:.   ||.||:||||.:....|| |.||.||:::|||.|||.|.:....||.:
  Fly     5 ILAIILVFVISSQSEAVIPGCDYFDTVDISHIPKL-NDSYAYEELIIPAHLTGLYTFRQLADGSQ 68

  Fly    71 VSVPKHIRGCVCKLKTCIRFCCHHKKLMAGNLCSQDVYENL----TYEYTLDITQLNGSVIKKHV 131
            ..|..|:|.|:||||.||||||...|:|..:.||..:.|||    .|   |.||..:|::.|.::
  Fly    69 EPVKSHLRACICKLKPCIRFCCPRNKMMPNSRCSDGLTENLKRINPY---LKITLEDGTIGKYYL 130

  Fly   132 LNDMVVQQDLPLPCERHYSLDAETSTYDMWSLYENGSLFRHFDQRY-LSKQEFCLQPNPTSTGKN 195
            |.||:|.:.....||:..|:..     |.:.||||||.....|..: ||||.:||.|.
  Fly   131 LTDMIVLRYEFRYCEKVVSVQE-----DQYKLYENGSFMIKPDVNWTLSKQWYCLHPR------- 183

  Fly   196 YSLIVAFNCIQKPS----MKMAYGRFECVRKSRLSNASIP-VKFSSVFFMVITIAAYLWLPKFRS 255
                     ::.|:    ::..|     :.||.   .::| |...|:...::|||.||::.|.|:
  Fly   184 ---------LEDPNSIWILEHVY-----IPKSM---PAVPQVGTISMVGCILTIAVYLYIKKLRN 231

  Fly   256 LHGKCCNLYFICLAITFLLNVISLFGIFELKTPICYLTGYAGYFTVMATFLWLSVISFDVWRRFA 320
            |.|||...|..|..:.:|   |...|...|...||.|.||..||..:|:..||||:|..:|
  Fly   232 LLGKCFICYVFCKFVQYL---IWAGGDLNLWNNICSLAGYTNYFFALASHFWLSVMSHQIW---- 289

  Fly   321 MRKFQVFYKNKRS-SFFNYNIIVWSSAGLLTCIIFLVDQFVETNLDNP----YNPAVGVFSCWIF 380
             :..::..:::|| .|..|||..|.:..::|.|.:|||...|   |.|    :.|.||::.|||.
  Fly   290 -KNLRLINRDERSYHFLIYNIYGWGTPAIMTAITYLVDWAWE---DRPDKLNWIPGVGLYRCWIN 350

  Fly   381 TNGWSATFYFYAPLAILIILNCASFFLTTRYIYVENKQNQKVLNNSEPQKLSRNHANYRIYFRLF 445
            |..|||..|.|.|:.||.:.|..:|.||..:|.   |....|.::::.|:....:.::.:|.||.
  Fly   351 TYDWSAMIYLYGPMLILSLFNVVTFILTVNHIM---KIKSSVKSSTQQQRKCIQNNDFLLYLRLS 412

  Fly   446 IIMGGSWFLEIIAFICEMENMWKPLIILNDYINCSQGIIIFVATFCNHEMFRLIRKRI 503
            ::||.:...|:|.:..:....|:.::.:.::.:...||::||........|::|.:||
  Fly   413 VMMGVTGISEVITYFVKRHKFWRQVLRVPNFFHLGSGIVVFVLFILKRSTFQMIMERI 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl11	NP_731479.3	Methuselah_N	26..204	CDD:310923	71/182 (39%)
		7tmB3_Methuselah-like	236..504	CDD:320167	86/273 (32%)
		TM helix 2	258..280	CDD:320167	7/21 (33%)
		TM helix 3	291..318	CDD:320167	12/26 (46%)
		TM helix 4	335..355	CDD:320167	7/19 (37%)
		TM helix 5	383..412	CDD:320167	12/28 (43%)
		TM helix 6	433..460	CDD:320167	7/26 (27%)
		TM helix 7	468..493	CDD:320167	4/24 (17%)
mthl6	NP_788473.1	Mth_Ecto	25..197	CDD:119403	72/196 (37%)
mthl6	NP_788473.1	7tm_4	211..398	CDD:304433	70/200 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	49	1.000	Domainoid score	I4416
eggNOG	1	0.900	-	-		E1_KOG4193
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	60	1.000	Inparanoid score	I5395
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG25921
OrthoDB	1	1.010	-	-		D111500at6656
OrthoFinder	1	1.000	-	-		FOG0003851
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR47154
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	8	7.980