DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl11 and mthl2

DIOPT Version :9

Sequence 1:	NP_731479.3	Gene:	mthl11 / 117467	FlyBaseID:	FBgn0045443	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	NP_788462.2	Gene:	mthl2 / 38636	FlyBaseID:	FBgn0035623	Length:	518	Species:	Drosophila melanogaster

Alignment Length:	504	Identity:	184/504 - (36%)
Similarity:	275/504 - (54%)	Gaps:	37/504 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLLGILVIGVRSRDIPNCDFFDTVQLRESEKLCNGSYRYEDVVIPAKLTGKYDYEIDYDGDRVSV 73
            |:..:|.:...|.:|.:|.|:|||.:.|.::|.||||.||.::|||.||.||::::..:||:..|
  Fly    14 LIYFLLNLQSSSAEIADCSFYDTVDISEGQRLSNGSYLYEGLLIPAHLTAKYEFKLLANGDKEQV 78

  Fly    74 PKHIRGCVCKLKTCIRFCCHHKKLMAGNLCSQDVYENLTYEYT------LDITQLNGSVIKKHVL 132
            |.|:|||||||:||:||||.|..:|....|    |.|:|.|..      |::|..:|||:::|..
  Fly    79 PSHVRGCVCKLRTCVRFCCPHDHIMDMGEC----YANMTTEENELLDPMLNVTLDDGSVVQRHYK 139

  Fly   133 NDMVVQQDLPLPCERHYSLDAETSTYDMWSLYENGSLFRHFDQRYLSKQEFCLQPNPTSTGKNYS 197
            .:::||.|||.||:..:.|| .....|.::|:|||.|.||:||.||.|.|:|||......|.|.|
  Fly   140 KELMVQWDLPKPCDDMFYLD-NRDIMDEYTLFENGRLLRHYDQVYLDKSEYCLQHRTFGEGNNNS 203

  Fly   198 L-IVAFNCIQKPSMKMAYGRFECVRKSRLSNASIPVKFSSVFFMVITIAAYLWLPKFRSLHGKCC 261
            : |:..||:..||                ......|..:|:..:|:|||.||.:.|..:|.|||.
  Fly   204 IRIIPHNCLILPS----------------RTGQTVVMITSLICLVLTIAVYLCVKKLMNLEGKCF 252

  Fly   262 NLYFICLAITFLLNVISLFGIFELKTPICYLTGYAGYFTVMATFLWLSVISFDVWRRFAMRKFQV 326
            ..|.:||...:|..::.|   :||....|...|:.|||.|||.|.|||:||...|:........:
  Fly   253 ICYMMCLFFGYLFLLLDL---WELSLDFCKAAGFLGYFFVMAAFFWLSIISRHYWKCLTNPCASM 314

  Fly   327 FYKNKRSSFFNYNIIVWSSAGLLTCIIFLVDQFVETNLDNPYNPAVG-VFSCWIFTNGWSATFYF 390
            ..:::| :|..|:...|:....||.:.:|.|..|.   :..:.|.|| ...|||:|..|||..||
  Fly   315 NIRSER-AFLLYSCFAWAMPLALTGVTYLADNVVN---NEEWQPRVGDEGHCWIYTKSWSAMVYF 375

  Fly   391 YAPLAILIILNCASFFLTTRYIYVENKQNQKVL-NNSEPQKLSRNHANYRIYFRLFIIMGGSWFL 454
            |.|:.:||:.|...|.||.::|....:..:|:. |....|||:.:..||..:..||.:||.||..
  Fly   376 YGPMVLLILFNITMFVLTAKHIIDSKRTLRKIARNEGRIQKLNSDKQNYTQFLLLFTVMGMSWSF 440

  Fly   455 EIIAFICEMENMWKPLIILNDYINCSQGIIIFVATFCNHEMFRLIRKRI 503
            ||.:::.:.|.:|..:.::.||.|.|||:||||......:...|.:|:|
  Fly   441 EIFSYLVQREKLWVNIFLVADYFNWSQGVIIFVLFILRRKTLVLFKKQI 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl11	NP_731479.3	Methuselah_N	26..204	CDD:310923	81/184 (44%)
		7tmB3_Methuselah-like	236..504	CDD:320167	94/270 (35%)
		TM helix 2	258..280	CDD:320167	7/21 (33%)
		TM helix 3	291..318	CDD:320167	14/26 (54%)
		TM helix 4	335..355	CDD:320167	5/19 (26%)
		TM helix 5	383..412	CDD:320167	13/28 (46%)
		TM helix 6	433..460	CDD:320167	10/26 (38%)
		TM helix 7	468..493	CDD:320167	10/24 (42%)
mthl2	NP_788462.2	Methuselah_N	31..211	CDD:284145	81/184 (44%)
mthl2	NP_788462.2	7tm_4	221..>395	CDD:304433	64/180 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449694
Domainoid	1	1.000	49	1.000	Domainoid score	I4416
eggNOG	1	0.900	-	-		E1_KOG4193
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	60	1.000	Inparanoid score	I5395
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG25921
OrthoDB	1	1.010	-	-		D111500at6656
OrthoFinder	1	1.000	-	-		FOG0003851
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR47154
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	9	8.910