DRSC/TRiP Functional Genomics Resources

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Protein Alignment mthl11 and Adgrg5

DIOPT Version :9

Sequence 1:NP_731479.3 Gene:mthl11 / 117467 FlyBaseID:FBgn0045443 Length:532 Species:Drosophila melanogaster
Sequence 2:NP_001139444.1 Gene:Adgrg5 / 382045 MGIID:2685955 Length:524 Species:Mus musculus


Alignment Length:557 Identity:91/557 - (16%)
Similarity:189/557 - (33%) Gaps:165/557 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    38 EKLCNGSYRYEDVVIPAKLTGKYDYEI--DYDG-----------DRVSVPKHIR--------GCV 81
            :||.|.|:...::.:.........:::  |:.|           .:|..|..::        .||
Mouse    54 QKLLNASFGGHNLTLQTNSIQSLVFKLSCDFPGLSLSSTTLTNVSQVRAPHAMQFPAELTKGACV 118

  Fly    82 CKLKTCIRFCCHHKKLMAGNLCSQDVYENLTYEYTLDITQLNGSVIKKHVLNDMVVQQDLPLPCE 146
            ......:|..|.:  ....:|...|...:|...|.|      |:.:....:|::  |:.:.:...
Mouse   119 TSRPAELRLICIY--FFTAHLFQDDRNSSLLNNYVL------GAQLDHRPVNNL--QKPVNISFW 173

  Fly   147 RHYSLD------------AETSTYDMWSLYENGSLFRHFDQRYLSKQEFCLQPNPTSTGKNYSLI 199
            .:.||:            |..|::..||                  .|.|....|::|    .::
Mouse   174 HNRSLEGYTVSCVFWKEGASKSSWGAWS------------------PEGCYTEQPSAT----QVL 216

  Fly   200 VAFNCIQKPSMKMAYGRFECVRKSRLSNASIPVKFS-------------SVFFMVITIAAYLWLP 251
            ...|.:...::.|           :||...:|.:..             |:...::||..|....
Mouse   217 CHCNHLTYFAVLM-----------QLSGDPVPAELQVPLEYISFVGCSISIVASLLTILLYAQSR 270

  Fly   252 K--------FRSLHGKCCNLYFICLAITFLLNVISLFGIFELKTPICYLTGYAGYFTVMATFLWL 308
            |        ..:|:|.     .:.|.:||||:  |...:..:..|:|.:.....::.::::..|:
Mouse   271 KQSDSTTRIHMNLNGS-----VLLLNVTFLLS--SQMTLPTMPRPVCKVLAAVLHYALLSSLTWM 328

  Fly   309 SVISFDVWRRFAMRKFQVFYKNKRSSFFNYNIIVWSSAGLLTCIIFLVDQFVETNLDNPYNPAV- 372
            ::..|::: .|..|.:..:.   |.......::.|....||..::.::...|       |.|.| 
Mouse   329 AIEGFNLY-LFLGRVYNAYI---RRYLLKLCMLGWGFPALLVLLLLMIKSSV-------YGPCVT 382

  Fly   373 -------------GVFSCW--------IFTNGWSATFYFYAPLAILIILNCASFFLTTRYIYVEN 416
                         .|..||        |...|:..    :..|..|::|..|      .:|....
Mouse   383 SLSKSQENGTGFQNVSMCWIRSPMVHSILVMGYGG----FTSLFNLVVLAWA------LWILCRL 437

  Fly   417 KQNQKVLNNSEPQKLSRNHANYR---IYFRLFIIMGGSWFLEIIAFICEMENMWKPLIILNDYIN 478
            :..:|.|:   |..       ||   :...|.:::|.:|.|...:|...:    .|.:.|....|
Mouse   438 RAREKALS---PWA-------YRDTAMVLGLTVLLGTTWTLAFFSFGVFL----LPQLFLFTIFN 488

  Fly   479 CSQGIIIFVATFCNHEMFRLIRKRIQNRNITSLELTN 515
            ...|..:|: .||:.:.:.....:.:...::|.::|:
Mouse   489 SLYGFFLFL-WFCSQKRYSDAEAKAEMEAVSSSQMTH 524

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mthl11NP_731479.3 Methuselah_N 26..204 CDD:310923 30/198 (15%)
7tmB3_Methuselah-like 236..504 CDD:320167 54/300 (18%)
TM helix 2 258..280 CDD:320167 7/21 (33%)
TM helix 3 291..318 CDD:320167 2/26 (8%)
TM helix 4 335..355 CDD:320167 3/19 (16%)
TM helix 5 383..412 CDD:320167 5/28 (18%)
TM helix 6 433..460 CDD:320167 6/29 (21%)
TM helix 7 468..493 CDD:320167 7/24 (29%)
Adgrg5NP_001139444.1 GPS 184..228 CDD:366827 9/65 (14%)
7tm_GPCRs 242..514 CDD:391938 54/314 (17%)
TM helix 1 244..268 CDD:341315 4/23 (17%)
TM helix 2 277..298 CDD:341315 7/27 (26%)
TM helix 3 311..333 CDD:341315 1/21 (5%)
TM helix 4 353..369 CDD:341315 3/15 (20%)
TM helix 5 405..428 CDD:341315 4/26 (15%)
TM helix 6 449..474 CDD:341315 6/24 (25%)
TM helix 7 478..503 CDD:341315 7/25 (28%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4193
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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