DRSC/TRiP Functional Genomics Resources

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Protein Alignment mthl11 and Adgrf3

DIOPT Version :9

Sequence 1:NP_731479.3 Gene:mthl11 / 117467 FlyBaseID:FBgn0045443 Length:532 Species:Drosophila melanogaster
Sequence 2:XP_006535799.1 Gene:Adgrf3 / 381628 MGIID:2685887 Length:1059 Species:Mus musculus


Alignment Length:307 Identity:66/307 - (21%)
Similarity:119/307 - (38%) Gaps:56/307 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly   235 SSVFFMVITIAAY--LWLPKFRS-----LHGKCCNLYFICLAIT---FLLNVISLFGIFELKTPI 289
            :||..:::.:|.|  :|....|:     .|....|: .|||.:.   ||.:.....|...|   |
Mouse   700 ASVLALLVCLAIYGLVWRVVVRNKVAFFRHTTLFNM-VICLLVADTCFLGSPFLPSGYHSL---I 760

  Fly   290 CYLTGYAGYFTVMATFLWLSVISFDVWRRFAMRKFQVFYKNKRSSFFNYNIIVWSSAGLLTCIIF 354
            |.:|.:..:|..:|||.|:...:..:    |.:...||::..:.       :|.|...:|..:..
Mouse   761 CLVTAFLCHFFYLATFFWMLAQALVL----AHQLLFVFHQLSKH-------VVLSLMVMLGYLCP 814

  Fly   355 LVDQFVETNLDNPYNPAVGVFSCWIFTNGWSATFYFYAPLAILIILNCASFFLTTRYIYVENKQN 419
            |....|...|..|....:....|  |.||.....|.::. .:|.|:......|....:       
Mouse   815 LGFAGVTLGLYLPQRKYLWEGKC--FLNGGGVMLYSFSE-PVLAIVGVNGLVLVIAVL------- 869

  Fly   420 QKVL--NNSEPQKLSRNHANYRIYFRLFI---IMGGSWFLEIIAFICEMENMWKPLIILNDY--- 476
             |:|  :.||...:.:..|...:...|.|   |.|.:|.|.:.......        |::.|   
Mouse   870 -KLLRPSLSEGPTVEKRQALVGVLKALLILTPIFGLTWGLGVATLFDGS--------IVSHYAFS 925

  Fly   477 -INCSQGIIIFV-ATFCNHEMFRLIRKRIQ-NRNITS-LELTNTSRP 519
             :|..||:.|.| ....:.::...:|||:: :|:..| :.:.:.:||
Mouse   926 ILNSLQGVFILVFGCLTDKKVLEALRKRLRGSRSSNSAISMVSCTRP 972

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mthl11NP_731479.3 Methuselah_N 26..204 CDD:310923
7tmB3_Methuselah-like 236..504 CDD:320167 62/287 (22%)
TM helix 2 258..280 CDD:320167 6/24 (25%)
TM helix 3 291..318 CDD:320167 6/26 (23%)
TM helix 4 335..355 CDD:320167 3/19 (16%)
TM helix 5 383..412 CDD:320167 5/28 (18%)
TM helix 6 433..460 CDD:320167 7/29 (24%)
TM helix 7 468..493 CDD:320167 7/29 (24%)
Adgrf3XP_006535799.1 HRM 352..398 CDD:367186
GPS 635..678 CDD:366827
7tm_GPCRs 688..954 CDD:391938 61/287 (21%)
TM helix 1 689..714 CDD:341315 4/13 (31%)
TM helix 2 729..751 CDD:341315 7/22 (32%)
TM helix 3 762..789 CDD:341315 7/30 (23%)
TM helix 4 803..823 CDD:341315 4/19 (21%)
TM helix 5 842..871 CDD:341315 4/37 (11%)
TM helix 6 887..914 CDD:341315 7/26 (27%)
TM helix 7 918..943 CDD:341315 7/24 (29%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4193
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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