DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl11 and mthl10

DIOPT Version :9

Sequence 1:	NP_731479.3	Gene:	mthl11 / 117467	FlyBaseID:	FBgn0045443	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	NP_788446.2	Gene:	mthl10 / 38057	FlyBaseID:	FBgn0035132	Length:	585	Species:	Drosophila melanogaster

Alignment Length:	563	Identity:	167/563 - (29%)
Similarity:	271/563 - (48%)	Gaps:	62/563 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LLGILVIGV--------------------RSRDIPN--CDFFDTVQLRESEKLCNGSYRYEDVVI 52
            |||:|.:.|                    .:.|.||  |:|:|||.|.......||||.|...::
  Fly    18 LLGVLCLVVFRLIPGIPFGTYVMAERDHYHTIDDPNVPCNFYDTVNLTGHRLFPNGSYDYYGTIV 82

  Fly    53 PAKLTGKYDYEIDYDGDRVSVPKHIRGCVCKLKTCIRFCCHHKKLMAGNL--CSQDVYENLTY-- 113
            ||:|.|.|||......:|:.|.:|:||||||.|:|:..||..:::....:  |..|..:|.|:
  Fly    83 PAELVGTYDYIHSSLTERIEVREHVRGCVCKFKSCLNICCPWRQVFNSEVDGCIIDHSDNRTWPD 147

  Fly   114 EYTLDITQLNGSVIKKHVLNDMVVQQDLPLPCERHYSLDAETSTYDMWSLYENGSLFRHFDQRYL 178
            ...|:||..|.|.|..::.....:|..  .||.:.:||..||:.:|.:.|:||||:.|..|:..:
  Fly   148 PPMLNITFRNESTILVNMFTQFAIQSF--RPCPKMFSLQPETNNWDDYLLFENGSMLRVDDKLLI 210

  Fly   179 SKQEFCLQPNPTSTGKNYSLIVAFNCIQKPSMKMAYGRFECVRKSRLSNASIPVKFSSVFFMVIT 243
            .|.|||:.|...:....:..|...||    .|:..:...:.:.       |..:.| |:.||::|
  Fly   211 RKNEFCMVPTYVNESDMFYTIHPANC----DMQDDHSTVKIIN-------SYAMMF-SIPFMMLT 263

  Fly   244 IAAYLWLPKFRSLHGKCCNLYFICLAITF-LLNVISLFGIFELKTPICYLTGYAGYFTVMATFLW 307
            ||.||.:|:.|:.|||....|.|.|::.: .|..:.|:.: :.....|.:.||..||..|..::|
  Fly   264 IAVYLLIPELRNQHGKSLVCYLIGLSVGYSSLCYVQLYQV-DATGVTCKVFGYTAYFFFMGAYMW 327

  Fly   308 LSVISFDVWRRF-AMRKFQVFYKNKRSSFFNYNIIVWSSAGLLTCIIFLVDQFVETNLDNPYNPA 371
            |||||||:|..| ..|....|.:.||  |..|::..|..|.:.....:...|.  |||.....|.
  Fly   328 LSVISFDLWHNFRGTRGINRFQEKKR--FLFYSLYSWGIALVFLAFTYCAQQL--TNLPANLKPG 388

  Fly   372 V--GVFSCWIFTNGWSATFYFYAPLAILIILNCASFFLTTRYIY---------VENKQNQKVLNN 425
            :  ||: ||:..:.|:|..|||.|:..:::.|...|.:|...|:         :.::.:.|.|..
  Fly   389 IGDGVY-CWLDMSNWAAMIYFYGPILAIVVANTIMFIMTAIKIHGVQREMARIIASENSTKNLRT 452

  Fly   426 SEPQKLSRNHANYR--IYFRLFIIMGGSWFLEIIAFICEMENMWKPLIILNDYINCSQGIIIFVA 488
            .:.::..|..:|||  ::.|||:|||.:|..|:|::....:..|..|..::|..|..||.:||:.
  Fly   453 EKDKRFYRAWSNYRFGLFLRLFLIMGITWLTELISYFVGSDKGWSKLFYISDLANAMQGFLIFML 517

  Fly   489 TFCNHEMFRLIRKRIQN-RNITSLELTNTSRPVESEKMADVEL 530
            .....::..||..|..: |:.::...:..|....|..:|::.|
  Fly   518 FVMKKKVKHLITNRCSSVRDGSNQRQSQYSTKTTSSSVANLSL 560

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl11	NP_731479.3	Methuselah_N	26..204	CDD:310923	62/181 (34%)
		7tmB3_Methuselah-like	236..504	CDD:320167	87/282 (31%)
		TM helix 2	258..280	CDD:320167	6/22 (27%)
		TM helix 3	291..318	CDD:320167	14/26 (54%)
		TM helix 4	335..355	CDD:320167	4/19 (21%)
		TM helix 5	383..412	CDD:320167	9/28 (32%)
		TM helix 6	433..460	CDD:320167	13/28 (46%)
		TM helix 7	468..493	CDD:320167	7/24 (29%)
mthl10	NP_788446.2	Methuselah_N	56..236	CDD:284145	62/181 (34%)
mthl10	NP_788446.2	7tm_4	244..514	CDD:304433	84/283 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	49	1.000	Domainoid score	I4416
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	60	1.000	Inparanoid score	I5395
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D111500at6656
OrthoFinder	1	1.000	-	-		FOG0003851
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR47154
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	6.070