Protein Alignment mthl11 and mthl4

DIOPT Version :10

• Sequence 1: NP_731479.3
• Gene: mthl11 / 117467
• FlyBaseID: FBgn0045443
• Length: 532
• Species: Drosophila melanogaster
• Sequence 2: NP_788394.1
• Gene: mthl4 / 36960
• FlyBaseID: FBgn0034219
• Length: 517
• Species: Drosophila melanogaster
• Alignment Length: 517
• Identity: 170/517 - (32%)
• Similarity: 269/517 - (52%)
• Gaps: 69/517 - (13%)

  Fly     9 LLLGI--LVIGVRSRDIPNCDFFDTVQLRESEKLCNGSYRYEDVVIPAKLTGKYDYEIDYDGDRV 71
            ||:.:  |::...:.:||.|||||||.:.::.:..||||.||.::|||.||.:|||::..|..:.
  Fly     4 LLIAVLFLLMPKSNAEIPGCDFFDTVDISKAPRFSNGSYLYEGLLIPAHLTAEYDYKLLADDSKE 68

  Fly    72 SVPKHIRGCVCKLKTCIRFCCHHKKLMAGNLCSQDVYENLTYEYT--LDITQLNGSVIKKHVLND 134
            .|..|:|||.|.|:.||||||...:.|..:.|..|:.|:...::.  :::|..:|||:::|...|
  Fly    69 KVASHVRGCACHLRPCIRFCCPQYQKMQKSKCYGDMSEDELNKHDPFVNVTLSDGSVVRRHFKED 133

  Fly   135 MVVQQDLPLP-CERHYSLDAETSTYDMWSLYENGSLFRHFDQRYLSKQEFCLQ------------ 186
            ::||.||..| |.|.|.|:.|....: ::|:|||||.||:|:..|||:|:|:|
  Fly   134 LIVQSDLAKPGCPRMYFLNHELPGNE-FTLFENGSLLRHWDKVELSKREYCVQHLSFKDDSIRIA 197

  Fly   187 PN--PTS-----TGKNYSLIVAFNCIQKPSMKMAYGRFECVRKSRLSNASIPVKFSSVFFMVITI 244
            |:  |.|     |.|..:::::..||                                   ::||
  Fly   198 PHFCPLSSEHSRTWKTVAIVISLICI-----------------------------------ILTI 227

  Fly   245 AAYLWLPKFRSLHGKCCNLYFIC-LAITFLLNVISLFGIFELKTPICYLTGYAGYFTVMATFLWL 308
            :.||::.|.|:|||||    ||| ||..||.....:..:::..:..|...|:.|||:|||.|.||
  Fly   228 SVYLYVEKLRNLHGKC----FICYLASLFLGYFFLVLNVWKYSSGFCVTAGFLGYFSVMAAFFWL 288

  Fly   309 SVISFDVWRRFAMRKFQVFYKNKRSSFFNYNIIVWSSAGLLTCIIFLVDQFVETNLDNPYNPAVG 373
            |||...:..:|::....:......:.|..||:..|....::|.|.:..||.|:   :....|.||
  Fly   289 SVIGIHLRIKFSLASNCLHRLLPENPFRAYNLYAWGIPLIMTAITYTADQVVK---NEKLRPRVG 350

  Fly   374 V-FSCWIFTNGWSATFYFYAPLAILIILNCASFFLTTRYIYVENKQNQKVLNNSEPQKLSRNHAN 437
            | .:|||:|...:...|||.|:.:||..|...|.|:..|||...|..:.:::..:..:...:...
  Fly   351 VGKNCWIYTGDMTVMIYFYGPMLLLIAFNIIMFVLSAIYIYNIKKNVKGLVHKQQTNQQINDQQM 415

  Fly   438 YRIYFRLFIIMGGSWFLEIIAFICEMENMWKPLIILNDYINCSQGIIIFVATFCNHEMFRLI 499
            :.|:.||||:||.||..||::|:...:..|...:::.||.|.|||.||||.......:.:||
  Fly   416 FAIFLRLFILMGLSWSFEILSFLLTKQQAWARALMVADYFNWSQGTIIFVLFILKPSILKLI 477

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl11	NP_731479.3	Methuselah_N	26..204	CDD:429053	75/199 (38%)
		7tmB3_Methuselah-like	236..504	CDD:410632	88/266 (33%)
		TM helix 2	258..280	CDD:410632	10/22 (45%)
		TM helix 3	291..318	CDD:410632	13/26 (50%)
		TM helix 4	335..355	CDD:410632	6/19 (32%)
		TM helix 5	383..412	CDD:410632	9/28 (32%)
		TM helix 6	433..460	CDD:410632	11/26 (42%)
		TM helix 7	468..493	CDD:410632	10/24 (42%)
mthl4	NP_788394.1	Methuselah_N	23..201	CDD:429053	71/178 (40%)
		7tmB3_Methuselah-like	205..477	CDD:410632	90/313 (29%)
		TM helix 1	207..232	CDD:410632	7/59 (12%)
		TM helix 2	241..263	CDD:410632	10/25 (40%)
		TM helix 3	271..298	CDD:410632	13/26 (50%)
		TM helix 4	315..335	CDD:410632	6/19 (32%)
		TM helix 5	361..390	CDD:410632	9/28 (32%)
		TM helix 6	411..438	CDD:410632	11/26 (42%)
		TM helix 7	446..471	CDD:410632	10/24 (42%)