DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mthl11 and adgrg1

DIOPT Version :9

Sequence 1:	NP_731479.3	Gene:	mthl11 / 117467	FlyBaseID:	FBgn0045443	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	NP_001018317.1	Gene:	adgrg1 / 324948	ZFINID:	ZDB-GENE-030131-3671	Length:	648	Species:	Danio rerio

Alignment Length:	606	Identity:	111/606 - (18%)
Similarity:	208/606 - (34%)	Gaps:	184/606 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LLGILVIGVRSRDIPNC-----------DFFDTVQ-LRESEKLCNGSYRYEDVVIPAKLTGKYDY 62
            ||.:|::.|..::...|           |....|| ......:.|||.:.:  :|...|.|.|
Zfish   102 LLDLLIVEVNGKNHTLCKPNGLQGTCCTDLSQGVQDNAHMYGIVNGSVKGD--IITGDLKGNY-- 162

  Fly    63 EIDYDGDRVSVPKHIRGCVCKLKTCIRFCCHHKKLMAGNLCSQDVYENLTYEYTLDITQLNGSVI 127
              .:||..::         ||.|    ||...:....|....::|......:..:|:....|:||
Zfish   163 --IFDGAHIN---------CKEK----FCDEARLKPRGANMIEEVVMRFNAKGRVDLPCAQGTVI 212

  Fly   128 KKHVLNDMVVQQDLPLPCERHYSLDAETSTYDMWSL--------------YENGSLFRHFDQRYL 178
            :   :::.....:..:|..|....:...|.|...||              |:|.:||    :|..
Zfish   213 E---MDEEFTGHNFTVPAPRFVDANTIPSVYIPSSLRSVSRRKSKVVCTYYKNKTLF----ERGP 270

  Fly   179 SKQEF----------------CLQP----------NPTSTGKNYSLIVAFNCIQK---------- 207
            ||...                .::|          .|.|:|:    .|:::..|.
Zfish   271 SKSALLDDIVGLSVENETIRNLIEPVKIRFHHRPFAPDSSGR----CVSWDTKQDNEVNWKDDGC 331

  Fly   208 PSMKMAYGRFEC--------------VRKSRLSNASIPVKFSSV---FFMVITIAAYLWLPKFRS 255
            .::|:...:.||              .:||.:.:.......::|   ..:|..:..:.||.|.|
Zfish   332 DTVKINEEQTECHCNHLTYFAILVQVEQKSTVRHLKALTFITAVGCAVSLVSCLVLFYWLCKRR- 395

  Fly   256 LHGKCCNLYFICLAITFLLNVISLFGIFE------LKTPICYLTGYAGYFTVMATFLWLSVISFD 314
             .||...:..:...:...:.::.||.|..      ....:|.|||...::.:::|..|:
Zfish   396 -RGKKNQISLVHRGLVVAIFLLCLFFILTGILANVANETVCQLTGSLLHYGLLSTLCWM------ 453

  Fly   315 VWRRFAMRKFQVFYKNKRSSFFNYNIIVW-------SSAGLLTCIIFLV-DQFVE------TNLD 365
                 ||..|..|...::  .||..:.:|       ....||..|:..| |.:.|      .:::
Zfish   454 -----AMEVFHTFLLVRK--VFNSPLPIWIFYLMGFGFPFLLVSILLSVGDIYGERKIKPSDDVN 511

  Fly   366 NPYNPAVGVFSCWIFTNGWSATFYFY----APLAILIILNCASFFLTTRYIYVENKQNQKVLNNS 426
            |||.      .||: |.|..:....|    ..||:::.......||..|          ::.|..
Zfish   512 NPYR------MCWM-TEGDKSQLAHYIINIGLLAVVVSSGLVMLFLVVR----------EIRNRP 559

  Fly   427 EPQKLSRNHANYRIYFRLFIIMGGSWFLEIIAF--ICEMENMWKPLIILNDYINCSQGIIIFVAT 489
            :.:|:   |..:...:.|..:.|.:|.|..:.|  ..|:      .:.|...||..||..:.:..
Zfish   560 DWKKI---HVAFLSIWGLTCLYGTTWALGFLDFGPFSEV------TLFLFCIINSLQGFFLMLRY 615

  Fly   490 FCNHEMFRLIRKRIQNRNITS 510
            :.        .:|::.::::|
Zfish   616 YA--------LERMKKKDVSS 628

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl11	NP_731479.3	Methuselah_N	26..204	CDD:310923	42/229 (18%)
		7tmB3_Methuselah-like	236..504	CDD:320167	58/296 (20%)
		TM helix 2	258..280	CDD:320167	2/21 (10%)
		TM helix 3	291..318	CDD:320167	5/26 (19%)
		TM helix 4	335..355	CDD:320167	6/26 (23%)
		TM helix 5	383..412	CDD:320167	7/32 (22%)
		TM helix 6	433..460	CDD:320167	6/28 (21%)
		TM helix 7	468..493	CDD:320167	5/24 (21%)
adgrg1	NP_001018317.1	GPS	312..354	CDD:280071	5/45 (11%)
adgrg1	NP_001018317.1	7tm_4	369..611	CDD:304433	57/282 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900