DRSC/TRiP Functional Genomics Resources

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Protein Alignment mthl11 and mthl15

DIOPT Version :10

Sequence 1:NP_731479.3 Gene:mthl11 / 117467 FlyBaseID:FBgn0045443 Length:532 Species:Drosophila melanogaster
Sequence 2:NP_723538.3 Gene:mthl15 / 318914 FlyBaseID:FBgn0051720 Length:718 Species:Drosophila melanogaster


Alignment Length:513 Identity:128/513 - (24%)
Similarity:216/513 - (42%) Gaps:112/513 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    65 DYDGDRVSVPKH---IRGC----VCKLKTCIRFCCHHKKLMA-GNL---CSQD-------VYENL 111
            |.|.||.::|:.   :|.|    :|:...|||.||...::.| ||.   |..|       .::||
  Fly   232 DADLDRGALPEQKFLVRACQEMKICQKIPCIRRCCAEGEMYAKGNFSTYCKIDGTDFKFEGFQNL 296

  Fly   112 TYEYTLDITQLNGSVIKKHVLNDMVVQQDLPLPCERHYSLDAETSTYDMWSLY-ENGSLFRHFDQ 175
                     .:|.:..|.   :|..:...|..|   .:.||.:....|..::. .||||..|...
  Fly   297 ---------NINANFSKP---SDFGIVHGLQCP---KFRLDPDNFPDDSHTINPSNGSLIIHNTF 346

  Fly   176 RYLSKQEFCLQ---PNPTSTGKNYSLIVAFNCIQKPSMKMAYGRFECVRKSRLSNASIPV-KFSS 236
            :..:..::|::   ||.    |.|:    |.|...          :.|...|:.....|: ...|
  Fly   347 KTYTNTQYCVERVRPNQ----KLYT----FLCFDN----------KVVTGDRIRFKMYPIGLLIS 393

  Fly   237 VFFMVITIAAYLWLPKFRSLHGKCCNLYFICLAITFLLNVISLFGIF------ELK----TPICY 291
            ..|..:|:..|:.:.|.|:|.||    ..|||       |.|||..:      :|:    ..||:
  Fly   394 CCFYALTLIVYISIAKLRNLPGK----ILICL-------VSSLFAAYLGIALGQLRPTSNDDICF 447

  Fly   292 LTGYAGYFTVMATFLWLSVISFDVWRRFAMRKFQVFYKNK-RSSFFNYNIIVWSSAGLLTCIIFL 355
            |:|:..||.:||.|.|:::.|||:|:.|...|.:...|:. |..|..|:...|   ||.|.:..:
  Fly   448 LSGFFVYFCLMAAFSWMNITSFDIWKTFGSTKLKSCEKSDLRRQFIWYSCYGW---GLPTLLTGI 509

  Fly   356 VDQFVETN-LDNPYNPAVGVFSCWIFTN---GWSATFYFYAPLAILIILNCASFFLTTRYIYVEN 416
            ...|.::: |.:...|..|...|| ||.   |.::..:|..|:.||.|:|...|.||.:|.   |
  Fly   510 TIAFTKSDILPDAVRPNFGHGRCW-FTYDSFGSASLLFFSGPVGILFIINLVLFVLTMKYC---N 570

  Fly   417 KQNQKV-----LNNSEP---QKLSRNHANYRIYFRLFIIMGGSWFLEIIAFIC---EMENMWKPL 470
            |...::     ||:.:|   ::..::...:.:..:|..:||.:|.|||::.:.   :....|   
  Fly   571 KVKNEIYKMQSLNSDKPVLKRRFFQDKTRFVMNTKLCFVMGITWLLEIVSILFYDHKKTFFW--- 632

  Fly   471 IILNDYINCSQGIIIFVATFCNHEMFRLIRKRIQNRNITSLELTNTSRPVESEKMADV 528
             .::|..|...||.:|:       :| :.::||.|..:....|.:......:...|.|
  Fly   633 -TISDSFNVLLGIFVFI-------IF-VFKRRIYNEIMFKFGLQSNPSTASTRTRAGV 681

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mthl11NP_731479.3 Methuselah_N 26..204 CDD:429053 39/160 (24%)
7tmB3_Methuselah-like 236..504 CDD:410632 80/293 (27%)
TM helix 2 258..280 CDD:410632 7/21 (33%)
TM helix 3 291..318 CDD:410632 12/26 (46%)
TM helix 4 335..355 CDD:410632 6/19 (32%)
TM helix 5 383..412 CDD:410632 10/28 (36%)
TM helix 6 433..460 CDD:410632 7/26 (27%)
TM helix 7 468..493 CDD:410632 5/24 (21%)
mthl15NP_723538.3 Mth_Ecto <247..355 CDD:448329 28/122 (23%)
7tmB3_Methuselah-like 379..665 CDD:410632 84/315 (27%)
TM helix 1 381..406 CDD:410632 5/24 (21%)
TM helix 2 415..437 CDD:410632 9/32 (28%)
TM helix 3 447..474 CDD:410632 12/26 (46%)
TM helix 4 492..512 CDD:410632 6/22 (27%)
TM helix 5 537..569 CDD:410632 10/31 (32%)
TM helix 6 595..622 CDD:410632 7/26 (27%)
TM helix 7 627..654 CDD:410632 7/38 (18%)

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