DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl11 and Adgre1

DIOPT Version :9

Sequence 1:	NP_731479.3	Gene:	mthl11 / 117467	FlyBaseID:	FBgn0045443	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	NP_001007558.1	Gene:	Adgre1 / 316137	RGDID:	1359214	Length:	932	Species:	Rattus norvegicus

Alignment Length:	308	Identity:	71/308 - (23%)
Similarity:	122/308 - (39%)	Gaps:	85/308 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   219 CVRKSRL----SNASIPVKFS-----------SVFFMVITIAAYLWLPKFRSL--HGKCCNLYF- 265
            |.|.:.|    ::..:.::||           |:..:.:.||.:|   .||::  |....:|:.
  Rat   627 CNRMTNLAIIMASGELTMEFSLYIISYVGTVISLVCLALAIATFL---LFRAVQNHNTYLHLHLC 688

  Fly   266 ICLAITFLLNVISLFGI--FELKTPICYLTGYAGYFTVMATFLW---------LSVISFDVWRRF 319
            :||   ||..::.|.||  .:.:|....:.|:..|. .:|.|.|         |.|.:..|...|
  Rat   689 VCL---FLAKILFLTGIDKTDNQTACAIIAGFLHYL-FLACFFWMLVEAVMLFLMVRNLKVVNYF 749

  Fly   320 AMRKFQVFYKNKRSSFFNYNIIVWSSAGLLTCIIFLVDQFVETNLDNPYNPAVGVFS-CWIFTNG 383
            :.|..::.:    ...|.|.:.|         ::.::...|     :|:  ..|:.: ||:.|..
  Rat   750 SSRNIKMLH----LCAFGYGLPV---------VVVIISATV-----HPW--GYGMHNRCWLNTET 794

  Fly   384 ---WSATFYFYAPLAILIILNCASFFLTTRYIYVENKQNQKVLN-NSEPQKLSRNH-ANYRIYFR 443
               ||    |..|:.::|.:|.|....|...:      .||:.: |||..||.... ..::...:
  Rat   795 GFIWS----FLGPVCMIITINSALLAWTLWVL------RQKLCSVNSEVSKLKDTRLLTFKAIAQ 849

  Fly   444 LFIIMGGSWFLEIIAFICEMENMWKPLIILNDY----INCSQGIIIFV 487
            :| |:|.||.|.|...        .||..:..|    ||..||..||:
  Rat   850 IF-ILGCSWVLGIFQI--------GPLASIMAYLFTTINSLQGAFIFL 888

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl11	NP_731479.3	Methuselah_N	26..204	CDD:310923
		7tmB3_Methuselah-like	236..504	CDD:320167	66/276 (24%)
		TM helix 2	258..280	CDD:320167	5/22 (23%)
		TM helix 3	291..318	CDD:320167	8/35 (23%)
		TM helix 4	335..355	CDD:320167	3/19 (16%)
		TM helix 5	383..412	CDD:320167	8/31 (26%)
		TM helix 6	433..460	CDD:320167	7/27 (26%)
		TM helix 7	468..493	CDD:320167	9/24 (38%)
Adgre1	NP_001007558.1	EGF_CA	33..63	CDD:238011
		EGF_CA	81..>109	CDD:214542
		EGF_CA	133..172	CDD:214542
		EGF_CA	173..>203	CDD:214542
		EGF_CA	222..255	CDD:214542
		cEGF	245..275	CDD:289433
		EGF_CA	272..>301	CDD:214542
		EGF_CA	319..359	CDD:284955
		Cell attachment site. /evidence=ECO:0000255	507..509
		GPS	592..641	CDD:197639	3/13 (23%)
		7tm_2	646..886	CDD:278432	66/285 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810