DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl11 and Adgrg6

DIOPT Version :9

Sequence 1:	NP_731479.3	Gene:	mthl11 / 117467	FlyBaseID:	FBgn0045443	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	XP_218313.7	Gene:	Adgrg6 / 308376	RGDID:	1308551	Length:	1248	Species:	Rattus norvegicus

Alignment Length:	268	Identity:	68/268 - (25%)
Similarity:	101/268 - (37%)	Gaps:	46/268 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   236 SVFFMVITIAAYLWLPKFRS------LHGKCCNLYFICLAITFLLN-VISLFGIFELKTPICYLT 293
            |..|...|:..|:...|.|.      |......|.|  |.:.|||: .|:.||:..|.|.:..|.
  Rat   873 SAIFSAATLLTYVAFEKLRRDYPSKILMNLSSALLF--LNLIFLLDGWITSFGVAGLCTAVAALL 935

  Fly   294 GYAGYFTVMATFLWLSVISFDVWRRFAMRKFQVFYKNKRSSFFNYNIIVWSSAGLLTCIIFLVDQ 358
                :|.::|||.|:.:.:..::  .|:.|  ||..........:.||.|....|:..||.:..:
  Rat   936 ----HFFLLATFTWMGLEAIHMY--IALVK--VFNTYIHRYILKFCIIGWGLPALVVSIILVSRK 992

  Fly   359 FVETNLDNPYNPAVGVFSCWIFTNGWSATFYFYAPLA----ILIILNCASFFLTTRYIYVEN-KQ 418
            ..|......|........|||     .....||...|    |:..||.|.|.:....|...| |:
  Rat   993 QNEVYGKESYGKDQDDEFCWI-----QDPVVFYVSCAGYFGIMFFLNVAMFIVVMVQICGRNGKR 1052

  Fly   419 NQKVLNNSEPQKLSRNHANYRIYFRLFIIMGGSWFLEIIAFICEMENMWKPLII----LNDYINC 479
            :.:.|.    :::.|   |.|....|..::|.:|.....|        |.||.|    |....|.
  Rat  1053 SNRTLR----EEVLR---NLRSVVSLTFLLGMTWGFAFFA--------WGPLNIPFMYLFSIFNS 1102

  Fly   480 SQGIIIFV 487
            .||:.||:
  Rat  1103 LQGLFIFI 1110

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl11	NP_731479.3	Methuselah_N	26..204	CDD:310923
		7tmB3_Methuselah-like	236..504	CDD:320167	68/268 (25%)
		TM helix 2	258..280	CDD:320167	7/22 (32%)
		TM helix 3	291..318	CDD:320167	6/26 (23%)
		TM helix 4	335..355	CDD:320167	6/19 (32%)
		TM helix 5	383..412	CDD:320167	8/32 (25%)
		TM helix 6	433..460	CDD:320167	7/26 (27%)
		TM helix 7	468..493	CDD:320167	9/24 (38%)
Adgrg6	XP_218313.7	CUB	38..146	CDD:238001
		LamG	178..337	CDD:304605
		GPS	799..844	CDD:280071
		7tm_4	861..1108	CDD:304433	66/264 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810