DRSC/TRiP Functional Genomics Resources

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Protein Alignment mthl11 and ADGRE2

DIOPT Version :9

Sequence 1:NP_731479.3 Gene:mthl11 / 117467 FlyBaseID:FBgn0045443 Length:532 Species:Drosophila melanogaster
Sequence 2:XP_011526250.1 Gene:ADGRE2 / 30817 HGNCID:3337 Length:837 Species:Homo sapiens


Alignment Length:632 Identity:123/632 - (19%)
Similarity:215/632 - (34%) Gaps:209/632 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 GVRSRDIPNCDFFDTVQ-LRESEK--LCNGSYRYEDVVIPAKLTGKYDYEIDYDGDRVSVPKHIR 78
            ||.|:.:..  |||.|| |....|  |.|.:.:        .:....|..::..||..::|:..:
Human   272 GVHSQTLSR--FFDKVQDLGRDYKPGLANNTIQ--------SILQALDELLEAPGDLETLPRLQQ 326

  Fly    79 GCVCK-----LKTCIRFCCHHKKLMAGNLCSQDVYENLTY----EYTLDI-TQLNGSVIKKHVLN 133
            .||..     |:..:|..  .|.|..|.|       |.:|    |.:|:: .|::.||..:.  |
Human   327 HCVASHLLDGLEDVLRGL--SKNLSNGLL-------NFSYPAGTELSLEVQKQVDRSVTLRQ--N 380

  Fly   134 DMVVQQDLPLPCERHYSLDAETSTYDMWSLYENGSLFRHFDQRYLSKQEFCLQP------NPTST 192
            ..|:|.|..   :...|.|...|...:.|:...|.|        |::....|:|      :.|..
Human   381 QAVMQLDWN---QAQKSGDPGPSVVGLVSIPGMGKL--------LAEAPLVLEPEKQMLLHETHQ 434

  Fly   193 G-----------------------KNYSLIVAFNCIQK---PSMKM-----AYGRFECVRKSRLS 226
            |                       :|.|..|.|....:   |..|:     .:|:..|...:...
Human   435 GLLQDGSPILLSDVISAFLSNNDTQNLSSPVTFTFSHRSVIPRQKVLCVFWEHGQNGCGHWATTG 499

  Fly   227 NASIPVKFSSVFFM---------------------VITIAAYLWLPKFRSLHGKCCNLYFICL-- 268
            .::|..:.:|....                     |:|:..|:.|           ::..:||  
Human   500 CSTIGTRDTSTICRCTHLSSFAVLMAHYDVQEEDPVLTVITYMGL-----------SVSLLCLLL 553

  Fly   269 -AITFLL--NVISLFGIFELKTPICYL------------TGY-------AG--YFTVMATFLWLS 309
             |:||||  .:.:......|:..:|..            ||:       ||  ::..:||..|: 
Human   554 AALTFLLCKAIQNTSTSLHLQLSLCLFLAHLLFLVAIDQTGHKVLCSIIAGTLHYLYLATLTWM- 617

  Fly   310 VISFDVWRRFAMRKFQVFYKNKRSSFFNYNIIVWSSAGLLTCIIFLVDQFVETNLDNPYNPAVGV 374
                      .:....:|...:..:..||:    |....:..::|.|...|         |||.|
Human   618 ----------LLEALYLFLTARNLTVVNYS----SINRFMKKLMFPVGYGV---------PAVTV 659

  Fly   375 --------------FSCWIFTNG---WSATFYFYAPLAILIILNCASFFLTTRYIYVENKQNQKV 422
                          ..||:....   |.    |..|:..:..:|.. .||.|.:|.    :|:..
Human   660 AISAASRPHLYGTPSRCWLQPEKGFIWG----FLGPVCAIFSVNLV-LFLVTLWIL----KNRLS 715

  Fly   423 LNNSEPQKLSRNH-ANYRIYFRLFIIMGGSWFLEIIAFICEMENMWKPLIILNDYINCSQGIIIF 486
            ..|||...|.... ..::...:|| |:|.:|.|.|:    ::....:.:..|...||..||:.||
Human   716 SLNSEVSTLRNTRMLAFKATAQLF-ILGCTWCLGIL----QVGPAARVMAYLFTIINSLQGVFIF 775

  Fly   487 VATFCNHEMFRLIRKRIQ------NRNITSLELTNTSRPVESEKMAD 527
            : .:|      |:.::::      ::.|..|:..:....:.|...||
Human   776 L-VYC------LLSQQVREQYGKWSKGIRKLKTESEMHTLSSSAKAD 815

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mthl11NP_731479.3 Methuselah_N 26..204 CDD:310923 47/219 (21%)
7tmB3_Methuselah-like 236..504 CDD:320167 63/332 (19%)
TM helix 2 258..280 CDD:320167 7/26 (27%)
TM helix 3 291..318 CDD:320167 7/47 (15%)
TM helix 4 335..355 CDD:320167 3/19 (16%)
TM helix 5 383..412 CDD:320167 7/31 (23%)
TM helix 6 433..460 CDD:320167 7/27 (26%)
TM helix 7 468..493 CDD:320167 8/24 (33%)
ADGRE2XP_011526250.1 EGF_CA 67..117 CDD:284955
EGF_CA 119..154 CDD:238011
EGF_CA 163..210 CDD:284955
EGF_CA 212..246 CDD:284955
GPS 479..529 CDD:197639 5/49 (10%)
7tm_4 533..774 CDD:304433 58/289 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4193
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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