DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl11 and Adgrf3

DIOPT Version :9

Sequence 1:	NP_731479.3	Gene:	mthl11 / 117467	FlyBaseID:	FBgn0045443	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	XP_006239862.1	Gene:	Adgrf3 / 298857	RGDID:	1305868	Length:	992	Species:	Rattus norvegicus

Alignment Length:	325	Identity:	68/325 - (20%)
Similarity:	122/325 - (37%)	Gaps:	64/325 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   235 SSVFFMVITIAAY--LWLPKFRS-----LHGKCCNLYFICLAIT---FLLNVISLFGIFELKTPI 289
            :|:..:::.:..|  :|....|:     .|....|: .|||.:.   ||.|.....|...|   :
  Rat   700 ASILALLVCLVIYRLVWRVVVRNKVAFFRHTALFNM-VICLLVADTCFLGNPWLPSGYHSL---V 760

  Fly   290 CYLTGYAGYFTVMATFLWLSVISFDVWRRFAMRKFQVFYKNKRSSFFNYNIIVWSSAGLLTCIIF 354
            |..|.:..:|..:|||.|:...:..:    |.:...||::..:.       :|.|...:|..:..
  Rat   761 CLATAFLCHFFYLATFFWMLAQALVL----AHQLLFVFHQLSKP-------LVLSMMSILGYLCP 814

  Fly   355 LVDQFVETNLDNPYNPAVGVFSCWIFTNGWSATFYFYAPLAILIILNCASFFLTTRYIYVENKQN 419
            |....|...|..|....:....|.:..:|.| ...|..|:..::.:|.....:..
  Rat   815 LGFAGVTLGLYLPQRKYLREGKCLLSGDGVS-LHAFSEPVLAIVSVNGLVLVIAV---------- 868

  Fly   420 QKVL--NNSEPQKLSRNHANYRIYFRLFI---IMGGSWFLEIIAFICEMENMWKPLIILNDYINC 479
            .|:|  :.||...:.:..|...:...|.|   |.|.:|.|.:.. :.|...::..:.::   :|.
  Rat   869 LKLLRPSLSEGPAVEKRQALVGVLKALLILTPIFGLTWGLGVTT-LFEGSLVFHYIFVI---LNS 929

  Fly   480 SQGIIIFV-ATFCNHEMFRLIRK-----RIQNRNITSLELTNTSRPVE-----------SEKMAD 527
            .||:.||| ....:.::...:||     |..|..|:.  :||.|...|           .|:|||
  Rat   930 LQGVFIFVFGCLTDKKVLEALRKWLRGSRSSNSAISM--VTNESCTSEHSRERSELASYEEQMAD 992

Fly 528 527
Rat 993 992

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl11	NP_731479.3	Methuselah_N	26..204	CDD:310923
		7tmB3_Methuselah-like	236..504	CDD:320167	58/288 (20%)
		TM helix 2	258..280	CDD:320167	7/24 (29%)
		TM helix 3	291..318	CDD:320167	6/26 (23%)
		TM helix 4	335..355	CDD:320167	3/19 (16%)
		TM helix 5	383..412	CDD:320167	5/28 (18%)
		TM helix 6	433..460	CDD:320167	7/29 (24%)
		TM helix 7	468..493	CDD:320167	6/25 (24%)
Adgrf3	XP_006239862.1	HRM	353..>395	CDD:295297
		GPS	632..679	CDD:197639
		7tm_4	687..935	CDD:304433	52/264 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810