DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl11 and Adgrg2

DIOPT Version :9

Sequence 1:	NP_731479.3	Gene:	mthl11 / 117467	FlyBaseID:	FBgn0045443	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	NP_852031.1	Gene:	Adgrg2 / 266735	RGDID:	628618	Length:	1013	Species:	Rattus norvegicus

Alignment Length:	412	Identity:	80/412 - (19%)
Similarity:	139/412 - (33%)	Gaps:	113/412 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   109 ENLTYEYTLDITQLNGSVIKKHVLNDMVVQQDLPLPCERHYSLDAETSTYDMWSLYENGSLFRHF 173
            :|||...|:.:..:|.|            |.||.:.|.             .|.|..||......
  Rat   542 KNLTRNVTVALKHINPS------------QDDLTVKCV-------------FWDLNRNGGRGGWS 581

  Fly   174 DQRYLSKQE-----FCLQPNPTSTGKNYSLIVAFNCIQKPSMKMA-----YGRFECVRKSRLSNA 228
            ......|::     .|...:.||.|   .|:........||..||     |
  Rat   582 SDGCSVKEKRMNETICTCSHLTSFG---ILLDLSRTSLPPSQMMALTFITY-------------- 629

  Fly   229 SIPVKFSSVFFMVITIAAYLWLPKFRS------LHGKCCNLYFICLAITFLLNVISLFGIFELKT 287
             |....||: |:.:|:..|:...|.|.      |...|..|  :.|.:.|||:  |...::..:.
  Rat   630 -IGCGLSSI-FLSVTLVTYIAFEKIRRDYPSKILIQLCAAL--LLLNLVFLLD--SWIALYNARG 688

  Fly   288 PICYLTGYAGYFTVMATFLWLSVISFDVWRRFAMRKFQVFYKNKRSSFFNYNIIVWSSAGLLTCI 352
            ....:..:..|| ::.:|.|:.:.:|.::    :...:||....|.....:.|:.|....::..|
  Rat   689 FCISVAVFLHYF-LLVSFTWMGLEAFHMY----LALVKVFNTYIRKYILKFCIVGWGIPAVVVSI 748

  Fly   353 IFLVDQFVETNLDNPYNPAVGVFS----------CWIFTNGWSATFYF--YAPLAILIILNCASF 405
            :..:         :|.|..:|.:.          |||.:   |..||.  .....::.:||.:.|
  Rat   749 VLTI---------SPDNYGIGSYGKFPNGTPDDFCWINS---SVVFYITVVGYFCVIFLLNVSMF 801

  Fly   406 FLT-TRYIYVENKQNQKVLNNSEPQKLSRNHANYRIYFRLFIIMGGSWFLEIIAFICEMENMWKP 469
            .:. .:...::.|:.......:..|.|       |....|..::|.:|.....|        |.|
  Rat   802 IVVLVQLCRIKKKKQLGAQRKTSIQDL-------RSIAGLTFLLGITWGFAFFA--------WGP 851

  Fly   470 LIILNDYI----NCSQGIIIFV 487
            :.:...|:    |..||..||:
  Rat   852 VNLTFMYLFAIFNTLQGFFIFI 873

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl11	NP_731479.3	Methuselah_N	26..204	CDD:310923	20/99 (20%)
		7tmB3_Methuselah-like	236..504	CDD:320167	53/275 (19%)
		TM helix 2	258..280	CDD:320167	7/21 (33%)
		TM helix 3	291..318	CDD:320167	5/26 (19%)
		TM helix 4	335..355	CDD:320167	3/19 (16%)
		TM helix 5	383..412	CDD:320167	6/31 (19%)
		TM helix 6	433..460	CDD:320167	5/26 (19%)
		TM helix 7	468..493	CDD:320167	7/24 (29%)
Adgrg2	NP_852031.1	GPS	566..608	CDD:280071	10/57 (18%)
Adgrg2	NP_852031.1	7tm_4	621..871	CDD:304433	56/301 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810