DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl11 and Adgre5

DIOPT Version :9

Sequence 1:	NP_731479.3	Gene:	mthl11 / 117467	FlyBaseID:	FBgn0045443	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	NP_036055.2	Gene:	Adgre5 / 26364	MGIID:	1347095	Length:	818	Species:	Mus musculus

Alignment Length:	413	Identity:	80/413 - (19%)
Similarity:	157/413 - (38%)	Gaps:	95/413 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   101 NLCSQDVYENLTYEYTLDITQLNGSVIKKHVLNDMVVQQDLPLPCERHYSLDAETSTYDMWSLYE 165
            |..::.:..|:|:::  |.|.:. |:..:|           .|.|.             .|..:
Mouse   452 NTNTEKLASNVTFKF--DFTSVE-SIEPRH-----------ELICA-------------FWKAH- 488

  Fly   166 NGSLFRHFDQRYLSKQEFCLQPNPTSTGKNYSLIVAFNCIQKPSMKMAYGRFECVRKSRLSNASI 230
            ||:.:...|...::...||...:.||    :::::|...:|.|       |.|.:.|..|
Mouse   489 NGNGYWDTDGCSMNGTGFCHCNHLTS----FAILMAQYHVQDP-------RLELITKVGL----- 537

  Fly   231 PVKFSSVFFMVITIAAYLWLPKFRS----LHGKCCNLYFICL---AITFLLNVISLFGIFELKTP 288
               ..|:..:::.|..:|.:...:|    :|...|    |||   :|.||:.|.:..|...|:
Mouse   538 ---LLSLICLLLCILTFLLVKPIQSSRTMVHLHLC----ICLFLGSIIFLVGVENEGGEVGLR-- 593

  Fly   289 ICYLTGYAGYFTVMATFLWLSVISFDVWRRFAMRKFQVFYKNKRSSFFNYNIIVWSSA--GLLTC 351
             |.|.....:|..:|.|.|:::...::: ...:|.||           ...:..|...  |....
Mouse   594 -CRLVAVMLHFCFLAAFCWMALEGVELY-FLVVRVFQ-----------GQGLSTWQRCLIGYGVP 645

  Fly   352 IIFLVDQFVETNLDNPYNPAVGVFSCWIFTNGWSATFYFYAPLAILIILNCASFFLTTRYIYVEN 416
            ::.:........:|. |..|.   .||:........:.|..|:|.:|..|.|.|.:|   ::...
Mouse   646 LLIVAISMAVVKMDG-YGHAT---YCWLDFRKQGFLWSFSGPVAFIIFCNAAIFVIT---VWKLT 703

  Fly   417 KQNQKVLNNSEPQKLSRNHANYRIYFRLFIIMGGSWFLEIIAFICEMENMWKPLIILNDYINCSQ 481
            |:..::  |...:||.:............:::|.:|...:  |:....:.|  |..:...:||.|
Mouse   704 KKFSEI--NPNMKKLRKARVLTITSIAQLLVLGCTWGFGL--FLFNPHSTW--LSYIFTLLNCLQ 762

  Fly   482 GIIIFVATFCNHEMFRLIRKRIQ 504
            |:.::|       |..|:.|:::
Mouse   763 GLFLYV-------MLCLLNKKVR 778

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl11	NP_731479.3	Methuselah_N	26..204	CDD:310923	18/102 (18%)
		7tmB3_Methuselah-like	236..504	CDD:320167	56/276 (20%)
		TM helix 2	258..280	CDD:320167	8/24 (33%)
		TM helix 3	291..318	CDD:320167	5/26 (19%)
		TM helix 4	335..355	CDD:320167	2/21 (10%)
		TM helix 5	383..412	CDD:320167	8/28 (29%)
		TM helix 6	433..460	CDD:320167	2/26 (8%)
		TM helix 7	468..493	CDD:320167	6/24 (25%)
Adgre5	NP_036055.2	EGF_CA	69..118	CDD:284955
		EGF_CA	165..212	CDD:284955
		EGF_CA	214..248	CDD:284955
		GPS	480..518	CDD:280071	10/55 (18%)
		7tm_2	526..766	CDD:278432	57/286 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	799..818
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810