DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl11 and mthl12

DIOPT Version :9

Sequence 1:	NP_731479.3	Gene:	mthl11 / 117467	FlyBaseID:	FBgn0045443	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	NP_731791.2	Gene:	mthl12 / 261599	FlyBaseID:	FBgn0045442	Length:	488	Species:	Drosophila melanogaster

Alignment Length:	506	Identity:	148/506 - (29%)
Similarity:	244/506 - (48%)	Gaps:	61/506 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 SRDIPNCDFFDTVQLRESEKLCNGSYRYEDVVIPAKLTGKYDYEIDYDGDRVSVP-KHIRGCVCK 83
            |..||:|.:.:|:.:...::| |.:|.||...|||.|||::||:...||.:|... .::|||:||
  Fly    21 SAKIPHCKYDETINISHFKRL-NDAYIYEHFEIPANLTGEFDYKELMDGSKVPTEFPNLRGCICK 84

  Fly    84 LKTCIRFCCHHKKLMAGNLCSQDVYENLTYEYTLDIT------------QLNGSVIKKHVLNDMV 136
            ::.|||.||..|.:::...||..|...:... .||:|            :||  :|.::...:::
  Fly    85 VRPCIRICCARKNILSNGECSDGVKNEIKLT-MLDLTMQDILLTDPTLAELN--MIPQYNSTELL 146

  Fly   137 VQQDLPLPCERHYSLDAETSTYDMWSLYENGSLFRHFDQRYLSKQEFCLQPNPTSTGKNYSLIVA 201
            :.::...||:...||..     |.:::.::||:..|.....||..::||.|...|.......|:.
  Fly   147 ILREQFQPCDEIVSLKR-----DEYTILKDGSILLHTSAEILSNDQYCLYPEIYSDFPETIRIIN 206

  Fly   202 FNCIQKPSMKMAYGRFECVRKSRLSNASIPVKFSSVFFMVITIAAYLWLPKFRSLHGKC--CNLY 264
            ..|.:.....:|                 .:...||...::|:|.||.:.|.|:|.|||  |:|:
  Fly   207 RRCYRNVMPGIA-----------------QLSVISVVGFILTLAVYLSVEKLRNLLGKCLICSLF 254

  Fly   265 FICLAITFLLNVISLFGIFELKTPICYLTGYAGYFTVMATFLWLSVISFDVWRRF-AMRKFQVFY 328
            .:     |:...|.....|.|...||...||..||..|:::||.||:||.:|..| ::.:.:..|
  Fly   255 SM-----FMEYFIWTMDYFRLLQSICSAAGYMKYFFSMSSYLWFSVVSFHLWELFTSLNRHEPQY 314

  Fly   329 KNKRSSFFNYNIIVWSSAGLLTCIIFLVDQFVETNL-DNPYNPAVGVFSCWIFTNGWSATFYFYA 392
            :     |..||..||.:|.:.|.:||.::|..|.:. .:.:.|.||.|.|.:  ..|:::.:||:
  Fly   315 R-----FLIYNTFVWCTAAIPTVVIFSMNQMWENDPGKSEWLPLVGYFGCSV--KDWNSSSWFYS 372

  Fly   393 --PLAILIILNCASFFLTTRYIYVENKQNQKVLNNSEPQK--LSRNHANYRIYFRLFIIMGGSWF 453
              |:.||...|...|.||..||:...|..:....:.|...  |..|...|..:.|||:|||.||.
  Fly   373 HIPIVILNSFNVIMFVLTAIYIWKVKKGVKSFAQHDERNTTCLEFNVQTYIQFVRLFLIMGASWL 437

  Fly   454 LEIIAFICEMENMWKPLIILN--DYINCSQGIIIFVATFCNHEMFRLIRKR 502
            |:.:..:.|..::....|:||  .|:|.:.||:|||........|::|.:|
  Fly   438 LDQLTRLAEDSHLLLDTIVLNLTVYLNAAFGILIFVLLILKGSTFKMIMER 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl11	NP_731479.3	Methuselah_N	26..204	CDD:310923	53/190 (28%)
		7tmB3_Methuselah-like	236..504	CDD:320167	90/277 (32%)
		TM helix 2	258..280	CDD:320167	7/23 (30%)
		TM helix 3	291..318	CDD:320167	12/26 (46%)
		TM helix 4	335..355	CDD:320167	8/19 (42%)
		TM helix 5	383..412	CDD:320167	10/30 (33%)
		TM helix 6	433..460	CDD:320167	11/26 (42%)
		TM helix 7	468..493	CDD:320167	10/26 (38%)
mthl12	NP_731791.2	Methuselah_N	27..209	CDD:284145	53/190 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	49	1.000	Domainoid score	I4416
eggNOG	1	0.900	-	-		E1_KOG4193
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	60	1.000	Inparanoid score	I5395
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG25921
OrthoDB	1	1.010	-	-		D111500at6656
OrthoFinder	1	1.000	-	-		FOG0003851
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR47154
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	8	7.980