DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment mthl11 and Adgrf5

DIOPT Version :9

Sequence 1:NP_731479.3 Gene:mthl11 / 117467 FlyBaseID:FBgn0045443 Length:532 Species:Drosophila melanogaster
Sequence 2:XP_038938942.1 Gene:Adgrf5 / 245977 RGDID:621679 Length:1426 Species:Rattus norvegicus


Alignment Length:325 Identity:62/325 - (19%)
Similarity:118/325 - (36%) Gaps:69/325 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   232 VKFSSVFFMVITIAAYL------W--LPKFRSLHGK--CCNLYFICLAIT---FLLNVISLFGIF 283
            :.:..:.|.::::||.|      |  :.|.|:.:.:  |.....:||.|.   |::......|.:
  Rat  1095 ISYIGLGFSIVSLAACLVVEAMVWKSVTKNRTSYMRHICIVNIALCLLIADIWFIVAGAIHDGHY 1159

  Fly   284 ELKTPICYLTGYAGYFTVMATFLWLSVISFDVWRRFAMRKFQVFYKNKRSSFFNYNIIVWSSAGL 348
            .|....|....:..:|..::.|.|:..:.           ..:||   |..|..::    :|...
  Rat  1160 PLNETACVAATFFIHFFYLSVFFWMLTLG-----------LMLFY---RLIFILHD----ASKST 1206

  Fly   349 LTCIIF-------LVDQFVETNLDNPYNPAVGVFSCWIFTNGWSATFYFYAPLAILIILNCASFF 406
            ...|.|       |:...:...:..|....:...:||:......|...|..|..|::::|.:   
  Rat  1207 QKAIAFSLGYGCPLIISSITVGVTQPQEVYMRKNACWLNWEDTRALLAFAIPALIIVVVNVS--- 1268

  Fly   407 LTTRYIYVENKQNQKVLNNSEPQKLSRNHAN--YRIYFRLFI---IMGGSWFLEIIAFICEMENM 466
            :|...|       .|:|..|...|..:...:  ::|...:.:   ::|.:|...:...|.....:
  Rat  1269 ITVVVI-------TKILRPSVGDKPGKQEKSSLFQISKSIGVLTPLLGLTWGFGLATVIQGSNAV 1326

  Fly   467 WKPLIILNDYINCSQGIIIF---------VATFCNHEMFRLIRKRIQNRNITSLELTNTSRPVES 522
            :..:..|   :|..||:.|.         |.....|: |.|.|...|:...|||   .:|.||.|
  Rat  1327 FHIIFTL---LNAFQGLFILLFGCLWDQKVQEALLHK-FSLSRWSSQHSKSTSL---GSSTPVFS 1384

  Fly   523  522
              Rat  1385  1384

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mthl11NP_731479.3 Methuselah_N 26..204 CDD:310923
7tmB3_Methuselah-like 236..504 CDD:320167 54/301 (18%)
TM helix 2 258..280 CDD:320167 5/26 (19%)
TM helix 3 291..318 CDD:320167 3/26 (12%)
TM helix 4 335..355 CDD:320167 4/26 (15%)
TM helix 5 383..412 CDD:320167 6/28 (21%)
TM helix 6 433..460 CDD:320167 3/31 (10%)
TM helix 7 468..493 CDD:320167 6/33 (18%)
Adgrf5XP_038938942.1 FR3 592..622 CDD:409353
Ig strand E 602..608 CDD:409353
Ig strand F 616..623 CDD:409353
CDR3 623..632 CDD:409353
GPS 1029..1076 CDD:396408
7tm_GPCRs 1090..1363 CDD:421689 52/299 (17%)
TM helix 1 1091..1116 CDD:410628 4/20 (20%)
TM helix 2 1131..1153 CDD:410628 5/21 (24%)
TM helix 3 1167..1190 CDD:410628 3/33 (9%)
TM helix 4 1210..1226 CDD:410628 3/15 (20%)
TM helix 5 1248..1271 CDD:410628 5/25 (20%)
TM helix 6 1295..1320 CDD:410628 3/24 (13%)
TM helix 7 1325..1350 CDD:410628 5/27 (19%)
SEA 181..273 CDD:396113
IG 298..372 CDD:214652
Ig_3 548..621 CDD:404760
FR1 548..567 CDD:409353
Ig strand A 548..551 CDD:409353
Ig strand A' 555..557 CDD:409353
Ig strand B 561..568 CDD:409353
CDR1 568..575 CDD:409353
Ig strand D 591..598 CDD:409353
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4193
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

Return to query results.
Submit another query.