DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl11 and Adgrd1

DIOPT Version :9

Sequence 1:	NP_731479.3	Gene:	mthl11 / 117467	FlyBaseID:	FBgn0045443	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	NP_001074811.1	Gene:	Adgrd1 / 243277	MGIID:	3041203	Length:	903	Species:	Mus musculus

Alignment Length:	335	Identity:	70/335 - (20%)
Similarity:	136/335 - (40%)	Gaps:	44/335 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   195 NYSLIVAFNCIQKPSMKMAYGRFECVRKSRLSNASIPVKFSSVFFMVITIAAYLWLPKFRSLHGK 259
            |::::     :|...:|:.:|     .:..||:.|......||..:..|:..:..|....::..:
Mouse   575 NFAIL-----MQVVPLKLTHG-----HQVALSSISYVGCSLSVLCLAATLVTFAVLSSVSTIRNQ 629

  Fly   260 ----CCNLYFICLAITFLLNVISLFGIFELKTPICYLTGYAGYFTVMATFLWLSVISFDVWRRFA 320
                ..||.|..|....|| :||.  ..|..|..|.:.....::..:..|.|:.|....::...
Mouse   630 RYHIHANLSFAVLVAQVLL-LISF--SMEPGTVPCQVLAVLLHYFFLTAFAWMLVEGLHLYSMV- 690

  Fly   321 MRKFQVFYKNKRSSFFNYNIIVWSSAGLLTCIIFLVDQFVETNLDNPYNPAVGVFSCWIFTNGWS 385
               .:||........:.|. |.| ...||.|||     .:.:::|: |..:   .|||: ..|..
Mouse   691 ---IKVFGSEDSKHLYYYG-IGW-GCPLLICII-----SISSSMDS-YGTS---DSCWL-ALGSG 740

  Fly   386 ATFYFYAPLAILIILNCASFFLTTRYIYVENKQNQKVLNNSEPQKLSRNHANYRIYFRLFIIMGG 450
            |.:.|..|..::|::|.......||.|...:..:.|:..:....||:.     :....|..|:|.
Mouse   741 AIWAFVGPALLVIVVNIVILVAVTRVISHISTDSYKIHGDPSAFKLTA-----KAVAVLLPILGT 800

  Fly   451 SWFLEIIAFICEMENMWKPLIILNDYINCSQGIIIFV-ATFCNHEMFRLIRKRIQNRNITSLEL- 513
            ||...::| :.:...:::.:..:   :|..||:.||: ....|.|:....:.:.:..::||...
Mouse   801 SWVFGVLA-VSDRALVFQYMFAI---LNSLQGLFIFLFHCLLNSEVRAAFKHKTKVWSLTSSSAR 861

  Fly   514 TNTSRPVESE 523
            |..::|..|:
Mouse   862 TANTKPFSSD 871

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl11	NP_731479.3	Methuselah_N	26..204	CDD:310923	1/8 (13%)
		7tmB3_Methuselah-like	236..504	CDD:320167	58/272 (21%)
		TM helix 2	258..280	CDD:320167	8/25 (32%)
		TM helix 3	291..318	CDD:320167	3/26 (12%)
		TM helix 4	335..355	CDD:320167	8/19 (42%)
		TM helix 5	383..412	CDD:320167	8/28 (29%)
		TM helix 6	433..460	CDD:320167	6/26 (23%)
		TM helix 7	468..493	CDD:320167	5/25 (20%)
Adgrd1	NP_001074811.1	Laminin_G_3	<173..273	CDD:290121
		GPS	539..579	CDD:280071	1/3 (33%)
		Stachel. /evidence=ECO:0000250\|UniProtKB:Q6QNK2	575..583		2/12 (17%)
		7tm_4	595..831	CDD:304433	57/263 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	862..903		3/10 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810