DRSC/TRiP Functional Genomics Resources

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Protein Alignment mthl11 and Adgrg2

DIOPT Version :9

Sequence 1:NP_731479.3 Gene:mthl11 / 117467 FlyBaseID:FBgn0045443 Length:532 Species:Drosophila melanogaster
Sequence 2:XP_006528869.1 Gene:Adgrg2 / 237175 MGIID:2446854 Length:1092 Species:Mus musculus


Alignment Length:420 Identity:84/420 - (20%)
Similarity:149/420 - (35%) Gaps:103/420 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   109 ENLT---YEYTLDITQL-------NGSVIKKHVLNDMVVQQDLPLPC-----ERHYSLDAETSTY 158
            ||||   |..:..:|.:       |.:|..||:...   ..||.:.|     .|:.:....|...
Mouse   595 ENLTLISYVISSSVTNMTIKNLTRNVTVALKHINPS---PDDLTVKCVFWDLGRNDTALVPTGGK 656

  Fly   159 DMWSLYENGSLFRHFDQRYLSKQEFCLQPNPTSTGKNYSLIVAFNCIQKPSMKMA-----YGRFE 218
            ..||  .:|...:  |:|  ..:..|...:.||.|   .|:........||..||     |    
Mouse   657 GGWS--SDGCSVK--DKR--MNETICTCSHLTSFG---ILLDLSRTSLPPSQMMALTFITY---- 708

  Fly   219 CVRKSRLSNASIPVKFSSVFFMVITIAAYLWLPKFRSLHGKCCNLYFICLAITFLLNVI----SL 279
                       |....||: |:.:|:..|:...|.|..:.... |..:|.|: .|||:|    |.
Mouse   709 -----------IGCGLSSI-FLSVTLVTYIAFEKIRRDYPSKI-LIQLCAAL-LLLNLIFLLDSW 759

  Fly   280 FGIFELKTPICYLTGYAGYFTVMATFLWLSVISFDVWRRFAMRKFQVFYKNKRSSFFNYNIIVWS 344
            ..::..: ..|.......::.::.:|.|:.:.:|.::    :...:||....|.....:.|:.|.
Mouse   760 IALYNTR-GFCIAVAVFLHYFLLVSFTWMGLEAFHMY----LALVKVFNTYIRKYILKFCIVGWG 819

  Fly   345 SAGLLTCIIFLVDQFVETNLDNPYNPAVGVFS----------CWIFTNGWSATFYF--YAPLAIL 397
            ...::..|:..:         :|.|..:|.:.          |||.:|   ..||.  .....::
Mouse   820 IPAVVVSIVLTI---------SPDNYGIGSYGKFPNGTPDDFCWINSN---VVFYITVVGYFCVI 872

  Fly   398 IILNCASFFLT-TRYIYVENKQNQKVLNNSEPQKLSRNHANYRIYFRLFIIMGGSWFLEIIAFIC 461
            .:||.:.|.:. .:...::.|:.......:..|.|       |....|..::|.:|.....|   
Mouse   873 FLLNVSMFIVVLVQLCRIKKKKQLGAQRKTSIQDL-------RSIAGLTFLLGITWGFAFFA--- 927

  Fly   462 EMENMWKPLIILNDYI----NCSQGIIIFV 487
                 |.|:.:...|:    |..||..||:
Mouse   928 -----WGPVNVTFMYLFAIFNTLQGFFIFI 952

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mthl11NP_731479.3 Methuselah_N 26..204 CDD:310923 25/109 (23%)
7tmB3_Methuselah-like 236..504 CDD:320167 52/273 (19%)
TM helix 2 258..280 CDD:320167 8/25 (32%)
TM helix 3 291..318 CDD:320167 3/26 (12%)
TM helix 4 335..355 CDD:320167 3/19 (16%)
TM helix 5 383..412 CDD:320167 5/31 (16%)
TM helix 6 433..460 CDD:320167 5/26 (19%)
TM helix 7 468..493 CDD:320167 7/24 (29%)
Adgrg2XP_006528869.1 Atrophin-1 <288..>423 CDD:367360
PRK14948 <368..559 CDD:237862
GPS 637..687 CDD:366827 12/58 (21%)
7tmB2_GPR64 700..969 CDD:320560 57/303 (19%)
TM helix 1 703..727 CDD:320560 7/39 (18%)
TM helix 2 737..758 CDD:320560 7/22 (32%)
TM helix 3 770..792 CDD:320560 2/21 (10%)
TM helix 4 812..828 CDD:320560 2/15 (13%)
TM helix 5 858..881 CDD:320560 5/25 (20%)
TM helix 6 904..929 CDD:320560 7/39 (18%)
TM helix 7 933..958 CDD:320560 6/20 (30%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4193
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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