DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mthl11 and ADGRF2

DIOPT Version :9

Sequence 1:	NP_731479.3	Gene:	mthl11 / 117467	FlyBaseID:	FBgn0045443	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	NP_001355044.1	Gene:	ADGRF2 / 222611	HGNCID:	18991	Length:	708	Species:	Homo sapiens

Alignment Length:	386	Identity:	73/386 - (18%)
Similarity:	129/386 - (33%)	Gaps:	128/386 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   122 LNGSVIKKHVLNDMVVQQDLPLPCER------HYSLDAETSTYDM-WSLYENGSLFRHFDQRYL- 178
            |..|:::...:|.:|:...||...:|      ..|...|..|..: |...||     .:||:..
Human   351 LEASLLENVTVNGLVLSAILPKELKRISLIFEKISKSEERRTQCVGWHSVEN-----RWDQQACK 410

  Fly   179 -----SKQEFCLQPNPTSTGKNYSLIVAFNCIQKPSMKMAYGRFECVRKSRLSNASIPVKFSSVF 238
                 |:|..| :..|:....::|::::.:.::.
Human   411 MIQENSQQAVC-KCRPSKLFTSFSILMSPHILES------------------------------- 443

  Fly   239 FMVITIAAYLWLPKFRSLHGKCCNLYFICLAITFLL-NVISLFGIFELKTPICYLTGYAGYFTVM 302
             :::|...|:      .|....|:| .:||:|..|: :.::       ||.|.||. :.....:.
Human   444 -LILTYITYV------GLGISICSL-ILCLSIEVLVWSQVT-------KTEITYLR-HVCIVNIA 492

  Fly   303 ATFLWLSVISFDVWRRFAMRKF-------------QVFYKNKRSSFFNYNIIVWSSAGLL----- 349
            ||.|..     |||  |.:..|             ..|:.:    ||..::..|..|..|
Human   493 ATLLMA-----DVW--FIVASFLSGPITHHKGCVAATFFVH----FFYLSVFFWMLAKALLILYG 546

  Fly   350 TCIIF-------LVDQFVETNLDNPY----------NPAVGVFS---CWIFTNGWSATFYFYAPL 394
            ..|:|       ||..........|.          .|..|...   ||:..:...|...|..|.
Human   547 IMIVFHTLPKSVLVASLFSVGYGCPLAIAAITVAATEPGKGYLRPEICWLNWDMTKALLAFVIPA 611

  Fly   395 AILIILNCASFFLTTRYIYVENKQNQKVLNNS---EPQKLSRNHANYRIYFRLFIIMGGSW 452
            ..::::|    .:|...:.|  |..:..:.||   |.:.:.|...|..|   |..::|.:|
Human   612 LAIVVVN----LITVTLVIV--KTQRAAIGNSMFQEVRAIVRISKNIAI---LTPLLGLTW 663

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl11	NP_731479.3	Methuselah_N	26..204	CDD:310923	20/94 (21%)
		7tmB3_Methuselah-like	236..504	CDD:320167	53/259 (20%)
		TM helix 2	258..280	CDD:320167	6/22 (27%)
		TM helix 3	291..318	CDD:320167	8/26 (31%)
		TM helix 4	335..355	CDD:320167	7/31 (23%)
		TM helix 5	383..412	CDD:320167	5/28 (18%)
		TM helix 6	433..460	CDD:320167	6/20 (30%)
		TM helix 7	468..493	CDD:320167
ADGRF2	NP_001355044.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900