DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl11 and Adgrg6

DIOPT Version :9

Sequence 1:	NP_731479.3	Gene:	mthl11 / 117467	FlyBaseID:	FBgn0045443	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	XP_006512741.1	Gene:	Adgrg6 / 215798	MGIID:	1916151	Length:	1258	Species:	Mus musculus

Alignment Length:	364	Identity:	83/364 - (22%)
Similarity:	128/364 - (35%)	Gaps:	94/364 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   145 CERHYSLDA-ETSTYDMWSLYENGSLFRHFDQRYLSKQEFCLQPNPTST----GKNYSLIV---- 200
            |..|..||| ||...        .|.|.||.         .|...|.|.    |:|..::.
Mouse   830 CVAHSDLDAGETICL--------CSHFTHFG---------VLMDLPRSASQIDGRNTKVLTFITY 877

  Fly   201 ---AFNCIQKPSMKMAYGRFECVRKSRLSNASIPVKFSSVFFMVITIAAYLWLPKFRSLHGKCCN 262
               ..:.|...:..:.|..||.:|:.          :.|...|.:: :|.|:|           |
Mouse   878 IGCGISAIFSAATLLTYVAFEKLRRD----------YPSKILMNLS-SALLFL-----------N 920

  Fly   263 LYFICLAITFLLNVISLFGIFELKTPICYLTGYAGYFTVMATFLWLSVISFDVWRRFAMRKFQVF 327
            |.|:      |...::.||:..|.|.:..|.    :|.::|||.|:.:.:..::  .|:.|  ||
Mouse   921 LIFL------LDGWVTSFGVAGLCTAVAALL----HFFLLATFTWMGLEAIHMY--IALVK--VF 971

  Fly   328 YKNKRSSFFNYNIIVWSSAGLLTCIIFLVDQFVETNLDNPYNPAVGVFSCWIFTNGWSATFYFYA 392
            ..........:.||.|....|:..||.:..:..|......|........|||     .....||.
Mouse   972 NTYIHRYILKFCIIGWGLPALVVSIILVSRRQNEVYGKESYGKDQDDEFCWI-----QDPVVFYV 1031

  Fly   393 PLA----ILIILNCASFFLTTRYIYVEN-KQNQKVLNNSEPQKLSRNHANYRIYFRLFIIMGGSW 452
            ..|    ::..||.|.|.:....|...| |::.:.|.    :::.|   |.|....|..::|.:|
Mouse  1032 SCAGYFGVMFFLNVAMFIVVMVQICGRNGKRSNRTLR----EEVLR---NLRSVVSLTFLLGMTW 1089

  Fly   453 FLEIIAFICEMENMWKPLII----LNDYINCSQGIIIFV 487
            .....|        |.||.|    |....|..||:.||:
Mouse  1090 GFAFFA--------WGPLNIPFMYLFSIFNSLQGLFIFI 1120

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl11	NP_731479.3	Methuselah_N	26..204	CDD:310923	16/70 (23%)
		7tmB3_Methuselah-like	236..504	CDD:320167	62/261 (24%)
		TM helix 2	258..280	CDD:320167	4/21 (19%)
		TM helix 3	291..318	CDD:320167	6/26 (23%)
		TM helix 4	335..355	CDD:320167	6/19 (32%)
		TM helix 5	383..412	CDD:320167	7/32 (22%)
		TM helix 6	433..460	CDD:320167	7/26 (27%)
		TM helix 7	468..493	CDD:320167	9/24 (38%)
Adgrg6	XP_006512741.1	CUB	48..156	CDD:238001
		LamG	188..347	CDD:389952
		HRM	543..588	CDD:382965
		GPS	809..854	CDD:366827	11/40 (28%)
		7tm_GPCRs	869..1137	CDD:391938	67/308 (22%)
		TM helix 1	871..896	CDD:341315	2/24 (8%)
		TM helix 2	906..928	CDD:341315	9/39 (23%)
		TM helix 3	939..966	CDD:341315	7/32 (22%)
		TM helix 4	981..997	CDD:341315	4/15 (27%)
		TM helix 5	1026..1049	CDD:341315	6/22 (27%)
		TM helix 6	1072..1097	CDD:341315	7/35 (20%)
		TM helix 7	1101..1126	CDD:341315	7/20 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810