DRSC/TRiP Functional Genomics Resources

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Protein Alignment mthl11 and Adgrl2

DIOPT Version :9

Sequence 1:NP_731479.3 Gene:mthl11 / 117467 FlyBaseID:FBgn0045443 Length:532 Species:Drosophila melanogaster
Sequence 2:NP_599235.3 Gene:Adgrl2 / 171447 RGDID:620835 Length:1487 Species:Rattus norvegicus


Alignment Length:440 Identity:90/440 - (20%)
Similarity:155/440 - (35%) Gaps:124/440 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   109 ENLTYEYTLDITQLNGSV-IKKHVLNDMVVQQDLPLPCERHYSLDA---ETSTYDMWSLYENGSL 169
            ||.|.:...|:...|.:: :..|||:..:.::.     .|.|..|.   .....|..:.:.....
  Rat   734 ENATVKLGADLLGRNSTIAVNSHVLSVSINKES-----SRVYLTDPVLFSMPHIDSDNYFNANCS 793

  Fly   170 FRHFDQR----YLSKQEFC--LQPNPTSTG------KNYSLIVAFNCIQKPSMKMAYGRFECVRK 222
            |.::.:|    |.|.|. |  :..|.|.|.      .|:::::|..              |.|.|
  Rat   794 FWNYSERTMMGYWSTQG-CKLVDTNKTRTTCACSHLTNFAILMAHR--------------EIVYK 843

  Fly   223 SRLSN--------ASIPVKFSSVFFMVITIAAYLWLPKFRSLHGK--CCNLYFICLAITFLLNVI 277
            ..:..        ..|.|....:...:.|...:..|...|:...|  |.||        |:...|
  Rat   844 DGVHKLLLTVITWVGIVVSLVCLAICIFTFCFFRGLQSDRNTIHKNLCINL--------FIAEFI 900

  Fly   278 SLFGI----FELKTPICYLTGYAG--YFTVMATFLWLSVISFDVWRRFAMRKFQVFYKNKRSSFF 336
            .|.||    :.:..|:     :||  :|..:|.|.|:.:....:: ...:..|:..|..|:..:.
  Rat   901 FLIGIDKTQYTIACPV-----FAGLLHFFFLAAFSWMCLEGVQLY-LMLVEVFESEYSRKKYYYV 959

  Fly   337 NYNIIVWSSAGLLTCIIFLVDQFVETNLDNPYNPAVGVFSCWIFTNG---WSATFYFYAPLAILI 398
            ...:...:..|:...|              .|.....:.:||:..:.   ||    |..|:..:|
  Rat   960 AGYLFPATVVGVSAAI--------------DYKSYGTLEACWLHVDNYFIWS----FIGPVTFII 1006

  Fly   399 ILNCASFFLTTRYIYVENKQNQKVLNNSEPQKLSR--NHANYRI---YF----------RLFIIM 448
            :||.. |.:.|....|::.      |..:|.. ||  |..|||:   |:          :.||  
  Rat  1007 LLNII-FLVITLCKMVKHS------NTLKPDS-SRLENINNYRVCDGYYNTDLPGYEDNKPFI-- 1061

  Fly   449 GGSWFLEIIAFICEMENMWK-PLIILND------YI----NCSQGIIIFV 487
             .||.|...|.:|.:...|. .|:.:|:      |:    |..||:.||:
  Rat  1062 -KSWVLGAFALLCLLGLTWSFGLLFVNEETVVMAYLFTAFNAFQGLFIFI 1110

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mthl11NP_731479.3 Methuselah_N 26..204 CDD:310923 23/110 (21%)
7tmB3_Methuselah-like 236..504 CDD:320167 62/289 (21%)
TM helix 2 258..280 CDD:320167 6/23 (26%)
TM helix 3 291..318 CDD:320167 6/28 (21%)
TM helix 4 335..355 CDD:320167 2/19 (11%)
TM helix 5 383..412 CDD:320167 9/31 (29%)
TM helix 6 433..460 CDD:320167 12/41 (29%)
TM helix 7 468..493 CDD:320167 8/31 (26%)
Adgrl2NP_599235.3 Gal_Lectin 49..129 CDD:396628
OLF 142..398 CDD:413369
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 422..462
HormR 469..533 CDD:214468
GAIN 542..764 CDD:406802 8/29 (28%)
GPS 788..840 CDD:197639 11/66 (17%)
7tm_GPCRs 848..1129 CDD:421689 64/306 (21%)
TM helix 1 850..875 CDD:410628 3/24 (13%)
TM helix 2 884..906 CDD:410628 8/29 (28%)
TM helix 3 915..942 CDD:410628 7/32 (22%)
TM helix 4 954..974 CDD:410628 2/19 (11%)
TM helix 5 991..1020 CDD:410628 9/33 (27%)
TM helix 6 1036..1087 CDD:410628 14/53 (26%)
TM helix 7 1091..1116 CDD:410628 6/20 (30%)
Latrophilin 1128..1487 CDD:396778
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1139..1160
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1386..1428
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4193
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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