DRSC/TRiP Functional Genomics Resources

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Protein Alignment mthl11 and Adgrl4

DIOPT Version :9

Sequence 1:NP_731479.3 Gene:mthl11 / 117467 FlyBaseID:FBgn0045443 Length:532 Species:Drosophila melanogaster
Sequence 2:NP_573485.2 Gene:Adgrl4 / 170757 MGIID:2655562 Length:739 Species:Mus musculus


Alignment Length:482 Identity:93/482 - (19%)
Similarity:170/482 - (35%) Gaps:167/482 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    88 IRFCCHHKKLMAGNLCSQDVYENLTYEYTLDITQLNGSVIKKHVLNDMV---VQQDLPLPCE--- 146
            :.|.|:  |.:...|.|.|       .:.|| ||.:.|..|:.|::.::   :..:.|...|   
Mouse   346 VAFLCY--KSIGPLLSSSD-------NFLLD-TQNDNSEGKEKVISSVISASISSNPPTLYELEK 400

  Fly   147 ------------RH--------YSLDAETSTYDMWSLYENGSLFRHFDQRYLSKQEFC------- 184
                        :|        ||:||..:  ..||  ..|....|.:..:.|.:  |       
Mouse   401 ITFTLSHVKLSDKHRTQCAFWNYSVDAMNN--GSWS--TEGCELTHSNDTHTSCR--CSHLTHFA 459

  Fly   185 -LQPNPTSTG-KNYSLIVAFNCIQKPSMKMAYGRFECVRKSRLSNASIPVKFSSVFFMVITIAAY 247
             |..:.:|.| |:|:::                       :|::...|.:   |:..:.|.|..:
Mouse   460 ILMSSTSSIGIKDYNIL-----------------------TRITQLGIII---SLICLAICIFTF 498

  Fly   248 LWLPKFRS----LH-GKCCNLYFICLAITFLLNVISLFGI-FELKTPIC-YLTGYAGYFTVMATF 305
            .:..:.:|    :| ..||:|        ||..::.|.|| ......:| .:.|...|| .:|.|
Mouse   499 WFFSEIQSTRTTIHKNLCCSL--------FLAELVFLIGININTNKLVCSIIAGLLHYF-FLAAF 554

  Fly   306 LWLSVISFDVW---------RRFAMRKFQVFYKNKRSSFFNYNIIVWSSAGLLTCIIFLVDQFVE 361
            .|:.:....::         :.|..:.|.:|      .:.:..::|..||               
Mouse   555 AWMCIEGIHLYLIVVGVIYNKGFLHKNFYIF------GYLSPAVVVGFSA--------------- 598

  Fly   362 TNLDNPYNPAVGVFSCWIFTNG---WSATFYFYAPLAILIILNCASFFLTTRYIYVENKQNQKVL 423
             :|...|.....|  ||:.|..   ||    |..|..::|::|..:|.:   .||       ||.
Mouse   599 -SLGYRYYGTTKV--CWLSTENNFIWS----FIGPACLIILVNLLAFGV---IIY-------KVF 646

  Fly   424 NNSEPQKLSRN-HANYRIYFR----LFIIMGGSWFLEIIAFICEMENMWKPLIILNDYI----NC 479
            .::...|...: :.|.|...|    |..::|.:|...::..:        ...::..|:    |.
Mouse   647 RHTAGLKPEVSCYENIRSCARGALALLFLLGTTWIFGVLHVV--------HASVVTAYLFTVSNA 703

  Fly   480 SQGIIIFVATFC------NHEMFRLIR 500
            .||:.||: ..|      ..|.:||.:
Mouse   704 FQGMFIFL-FLCVLSRKIQEEYYRLFK 729

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mthl11NP_731479.3 Methuselah_N 26..204 CDD:310923 31/150 (21%)
7tmB3_Methuselah-like 236..504 CDD:320167 60/299 (20%)
TM helix 2 258..280 CDD:320167 5/21 (24%)
TM helix 3 291..318 CDD:320167 6/35 (17%)
TM helix 4 335..355 CDD:320167 3/19 (16%)
TM helix 5 383..412 CDD:320167 7/31 (23%)
TM helix 6 433..460 CDD:320167 6/31 (19%)
TM helix 7 468..493 CDD:320167 7/34 (21%)
Adgrl4NP_573485.2 EGF_CA 58..91 CDD:214542
EGF_CA 108..141 CDD:214542
GAIN 190..370 CDD:293098 9/33 (27%)
GPS 417..461 CDD:280071 10/49 (20%)
7tm_4 473..709 CDD:304433 57/316 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4193
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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