DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl11 and adgrl2b.1

DIOPT Version :9

Sequence 1:	NP_731479.3	Gene:	mthl11 / 117467	FlyBaseID:	FBgn0045443	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	NP_001353776.1	Gene:	adgrl2b.1 / 110437953	ZFINID:	ZDB-GENE-130116-4	Length:	1454	Species:	Danio rerio

Alignment Length:	297	Identity:	62/297 - (20%)
Similarity:	113/297 - (38%)	Gaps:	71/297 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   225 LSNASIPVKFSSVFFMVITIAAYLWLPKFRSLHGK--CCNLYFICLAITFLLNVISLFGIFELKT 287
            ::...|.|....:...:.|...:..|...|:...|  |.||        |:..::.|.||...:.
Zfish   837 ITRLGIAVSLVCLAISIFTFCFFRGLQSDRNTIHKNLCINL--------FIAELLFLVGINMTEP 893

  Fly   288 PI-CYLTGYAGYFTVMATFLWLSVISFDVWRRFAMRKFQVFYKNKRSSFFNYNIIVWSSAGLLTC 351
            || |.:.....:|..:|.|.|:.:....::    :...:||     .|.|:.....::|..|..|
Zfish   894 PIVCSVIAGVLHFFFLAAFSWMCLEGVQLF----LMLVEVF-----ESEFSRRKYYYASGYLFPC 949

  Fly   352 IIFLVDQFVETNLDNPYNPAVGVFSCWIFTNG---WSATFYFYAPLAILIILNCASFFLTTRYIY 413
            ::..:...::      |.......:||:..:.   ||    |..|:..:|:||.. |.:.|.|..
Zfish   950 VVVGISAAID------YKSYGTKKACWLRVDNHFIWS----FIGPVTFIILLNLI-FLVVTMYKM 1003

  Fly   414 VENKQNQKVLNNSEPQKLSRNHANYRIYFRLFIIMGGSWFLEIIAFICEMENMWK-PLIILND-- 475
            |::..:.|. ::|..:.:.                  ||.....|.:|.:...|. .|:.|||
Zfish  1004 VKHSMSMKP-DSSRLESIR------------------SWVFGAFALLCLLCLTWSFGLLFLNDSS 1049

  Fly   476 ----YI----NCSQGIIIFVATFCNHEMFRLIRKRIQ 504
                |:    |..||:.||| ..|      |::|:::
Zfish  1050 VIMAYLFSIFNTLQGMFIFV-FHC------LLQKKVR 1079

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl11	NP_731479.3	Methuselah_N	26..204	CDD:310923
		7tmB3_Methuselah-like	236..504	CDD:320167	60/284 (21%)
		TM helix 2	258..280	CDD:320167	5/23 (22%)
		TM helix 3	291..318	CDD:320167	4/26 (15%)
		TM helix 4	335..355	CDD:320167	4/19 (21%)
		TM helix 5	383..412	CDD:320167	9/31 (29%)
		TM helix 6	433..460	CDD:320167	3/26 (12%)
		TM helix 7	468..493	CDD:320167	12/35 (34%)
adgrl2b.1	NP_001353776.1	Gal_Lectin	50..130	CDD:307994
		OLF	139..395	CDD:321983
		HormR	468..528	CDD:214468
		GAIN	538..746	CDD:318649
		GPS	770..822	CDD:197639
		7tm_GPCRs	831..1088	CDD:333717	62/297 (21%)
		TM helix 1	834..858	CDD:320672	3/20 (15%)
		TM helix 2	867..888	CDD:320672	6/28 (21%)
		TM helix 3	898..920	CDD:320672	4/21 (19%)
		TM helix 4	939..955	CDD:320672	3/15 (20%)
		TM helix 5	974..997	CDD:320672	8/27 (30%)
		TM helix 6	1021..1046	CDD:320672	6/42 (14%)
		TM helix 7	1050..1075	CDD:320672	9/31 (29%)
		Latrophilin	1087..1454	CDD:308136
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900