Protein Alignment mthl11 and adgre14

DIOPT Version :10

• Sequence 1: NP_731479.3
• Gene: mthl11 / 117467
• FlyBaseID: FBgn0045443
• Length: 532
• Species: Drosophila melanogaster
• Sequence 2: XP_021330419.2
• Gene: adgre14 / 108182849
• ZFINID: ZDB-GENE-131120-49
• Length: 688
• Species: Danio rerio
• Alignment Length: 493
• Identity: 96/493 - (19%)
• Similarity: 168/493 - (34%)
• Gaps: 148/493 - (30%)

  Fly    89 RFCCHHKKLMAGNLCSQDVYENLTYEYTLDITQLNGSV--IKKHVLNDMVVQQDLPLPCERHYSL 151
            |...::::||:..:...|...|:::    .:..:.|.|  :..||..|     ::|....|:.|:
Zfish   210 RVLINNEELMSTLVKQTDTSANVSF----TLADVEGRVFMVGPHVTLD-----EIPRLHTRNCSI 265

  Fly   152 DAETSTYDMWSLYENGS-------LFRHFD-QRYLSKQEF-----------------CLQPNPTS 191
            |     .|:..:..|.:       :|..:: ...|.|.:|                 ...|..|:
Zfish   266 D-----IDLIGIANNNNGTRSAAVIFLGYNTMENLLKADFFNATNDTVNTMMSSVISVTLPKTTN 325

  Fly   192 TGKNYSLIVAFNCIQK--PSMKMAYGRFECV---------------RKSR--------------- 224
            |..:..:...|..|::  ||     |.|.||               ..:|
Zfish   326 TALSKPVNFTFRHIREFDPS-----GSFSCVYWNISKWIVDGCSVLNTNRSFTVCSCVHLSTFAL 385

  Fly   225 -LSNASIPVKFSS--------------VFF--MVITIAAYLWLPKFRSLH--GKCCNLYFICLAI 270
             :...|.|.:..|              :||  .::|.....|.|...::.  ..|.:|  :...:
Zfish   386 IMQTRSHPPESDSLLNVLNVVCVIVGLLFFSLALLTFTRCQWSPGVNNVARINICISL--LLAHL 448

  Fly   271 TFLLNVISLFGIFELKTPICYLTGYAGYFTVMATFLWL---SVISFDVWRRFAMRKFQV--FYKN 330
            .|||.. ....:...:..:|.|.....:|..::.|:|:   :|:.|...:..:....|:  ..:|
Zfish   449 LFLLTQ-QFLSLIRRQKVLCMLISGLLHFLFLSGFVWMFIEAVLLFICVKNLSQISSQMKNVLRN 512

  Fly   331 KRSSFFNYNIIVWSSAGLLTCIIFLVDQFVETNLDNPYNP-AVGVFSCWIFTNG---WSATFYFY 391
            |                 |.|:|......|..::.....| ..|...|||..:.   ||    |.
Zfish   513 K-----------------LLCVIGYAVALVVVSISAAVVPNGYGSEKCWIQMHKGFIWS----FL 556

  Fly   392 APLAILIILNCASFFLTTRYIYVENKQNQKVLNNSEPQKLSRNHANYRIYFRL---FIIMGGSWF 453
            .|:.|:|.||...|.    .|....|...|.| |::..:|::...   :.|:.   |:::|.||.
Zfish   557 GPVTIIIALNVILFI----SIGFSLKSAFKKL-NADVSQLNQTKI---VMFKTLAQFVVLGCSWI 613

  Fly   454 LEIIAFICEMENMWKPLIILNDYINCSQGIIIFVATFC 491
            |....      |..|.|.||...:|..||..||: .:|
Zfish   614 LGFFT------NSSKVLEILFLILNSQQGTFIFL-IYC 644

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl11	NP_731479.3	Methuselah_N	26..204	CDD:429053	24/141 (17%)
		7tmB3_Methuselah-like	236..504	CDD:410632	62/286 (22%)
		TM helix 2	258..280	CDD:410632	5/21 (24%)
		TM helix 3	291..318	CDD:410632	6/29 (21%)
		TM helix 4	335..355	CDD:410632	3/19 (16%)
		TM helix 5	383..412	CDD:410632	9/31 (29%)
		TM helix 6	433..460	CDD:410632	6/29 (21%)
		TM helix 7	468..493	CDD:410632	10/24 (42%)
adgre14	XP_021330419.2	None