DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mthl11 and ADGRG2

DIOPT Version :9

Sequence 1:	NP_731479.3	Gene:	mthl11 / 117467	FlyBaseID:	FBgn0045443	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	NP_001073327.1	Gene:	ADGRG2 / 10149	HGNCID:	4516	Length:	1017	Species:	Homo sapiens

Alignment Length:	412	Identity:	81/412 - (19%)
Similarity:	142/412 - (34%)	Gaps:	115/412 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   110 NLTYEYTLDITQLNGSVIKKHVLNDMVVQQDLPLPCERHYSLDAETSTYDMWSLYENGSLFRHFD 174
            |||...|:.:..:|.|            |.:|.:.|.             .|.|..||......|
Human   547 NLTRNVTVTLKHINPS------------QDELTVRCV-------------FWDLGRNGGRGGWSD 586

  Fly   175 ------QRYLSKQEFCLQPNPTSTGKNYSLIVAFNCIQKPSMKMA-----YGRFECVRKSRLSNA 228
                  .|.|: :..|...:.||.|   .|:........|:..||     |
Human   587 NGCSVKDRRLN-ETICTCSHLTSFG---VLLDLSRTSVLPAQMMALTFITY-------------- 633

  Fly   229 SIPVKFSSVFFMVITIAAYLWLPKFRS------LHGKCCNLYFICLAITFLLNVISLFGIFELKT 287
             |....||: |:.:|:..|:...|.|.      |...|..|  :.|.:.|||:  |...:::::
Human   634 -IGCGLSSI-FLSVTLVTYIAFEKIRRDYPSKILIQLCAAL--LLLNLVFLLD--SWIALYKMQ- 691

  Fly   288 PICYLTGYAGYFTVMATFLWLSVISFDVWRRFAMRKFQVFYKNKRSSFFNYNIIVWSSAGLLTCI 352
            .:|.......::.::.:|.|:.:.:|.::    :...:||....|.....:.|:.|....::..|
Human   692 GLCISVAVFLHYFLLVSFTWMGLEAFHMY----LALVKVFNTYIRKYILKFCIVGWGVPAVVVTI 752

  Fly   353 IFLVDQFVETNLDNPYNPAVGVFS----------CWIFTNGWSATFYF--YAPLAILIILNCASF 405
            |..:         :|.|..:|.:.          |||..|   |.||.  .....::.:||.:.|
Human   753 ILTI---------SPDNYGLGSYGKFPNGSPDDFCWINNN---AVFYITVVGYFCVIFLLNVSMF 805

  Fly   406 FLT-TRYIYVENKQNQKVLNNSEPQKLSRNHANYRIYFRLFIIMGGSWFLEIIAFICEMENMWKP 469
            .:. .:...::.|:.......:..|.|       |....|..::|.:|.....|        |.|
Human   806 IVVLVQLCRIKKKKQLGAQRKTSIQDL-------RSIAGLTFLLGITWGFAFFA--------WGP 855

  Fly   470 LIILNDYI----NCSQGIIIFV 487
            :.:...|:    |..||..||:
Human   856 VNVTFMYLFAIFNTLQGFFIFI 877

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl11	NP_731479.3	Methuselah_N	26..204	CDD:310923	21/99 (21%)
		7tmB3_Methuselah-like	236..504	CDD:320167	54/275 (20%)
		TM helix 2	258..280	CDD:320167	7/21 (33%)
		TM helix 3	291..318	CDD:320167	3/26 (12%)
		TM helix 4	335..355	CDD:320167	4/19 (21%)
		TM helix 5	383..412	CDD:320167	6/31 (19%)
		TM helix 6	433..460	CDD:320167	5/26 (19%)
		TM helix 7	468..493	CDD:320167	7/24 (29%)
ADGRG2	NP_001073327.1	GPS	569..612	CDD:280071	12/59 (20%)
ADGRG2	NP_001073327.1	7tm_4	625..875	CDD:304433	57/301 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810