DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl11 and adgrf11

DIOPT Version :9

Sequence 1:	NP_731479.3	Gene:	mthl11 / 117467	FlyBaseID:	FBgn0045443	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	XP_005160858.1	Gene:	adgrf11 / 100537132	ZFINID:	ZDB-GENE-121214-165	Length:	691	Species:	Danio rerio

Alignment Length:	326	Identity:	70/326 - (21%)
Similarity:	117/326 - (35%)	Gaps:	87/326 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   236 SVFFMVIT--IAAYLWLPKFRSLHGKCCNLYFICLAITFLLNVISLFGIFELKTPICYLTGYA-- 296
            ||..:||:  |.|.:|....:|   ....|..:||..|   || ||     |...:|::.|.:
Zfish   385 SVLSLVISLIIGAIVWTTVTKS---NSAYLRHVCLVNT---NV-SL-----LVADVCFIIGASIV 437

  Fly   297 --------GYFTVMATFLWLSVISFDVWRRFAMRKF-----QVFYKNKRSSFFNYNIIVWSSAGL 348
                    |..|.:|..:.|..::|..|...:....     .|:.:..|:........:...|.|
Zfish   438 QPGQLAPVGPCTAVAFSMHLFFLAFFFWMLISAMLLLYMTTMVYSQMSRAKMMAIAFFLGYGAPL 502

  Fly   349 LTCIIFLVDQFVETNLDNPYNPAVGVFSCWIFTNGWSATFYFYAPLAILIILNCASFFLTT---- 409
            |..:|    .:..|..:..|.....|  ||:         .|....|:.|.::.||.|...
Zfish   503 LIVVI----TYGLTAREGKYILEADV--CWL---------NFDETKALQIFVSLASSFTAVNVLI 552

  Fly   410 ------RYIYVENKQNQKVLNNSEPQKLSRNHANYRIYFRLFIIMGGSWFLEIIAFICEMENMWK 468
                  :.:.|..:||::  .|..|...       |:...:..:.|.:|.|.|       ..|..
Zfish   553 IIVVLYKMLIVRKQQNKE--TNILPTVT-------RVVLIVSPLFGVTWGLGI-------GTMLS 601

  Fly   469 PLIILNDY--------INCSQGIIIFVA-TFCNHEMFRLIRKRIQNRNITSLELTNTSRPVESEK 524
            |     ||        :|..|||...|: ...|.::...:.:|...||.||   :|.:|.:::|:
Zfish   602 P-----DYGIHLVFTILNSLQGIFNLVSGLLVNSQVRNALAERWSLRNFTS---SNRTRTIQNEQ 658

  Fly   525 M 525
            :
Zfish   659 V 659

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl11	NP_731479.3	Methuselah_N	26..204	CDD:310923
		7tmB3_Methuselah-like	236..504	CDD:320167	63/303 (21%)
		TM helix 2	258..280	CDD:320167	7/21 (33%)
		TM helix 3	291..318	CDD:320167	7/36 (19%)
		TM helix 4	335..355	CDD:320167	4/19 (21%)
		TM helix 5	383..412	CDD:320167	6/38 (16%)
		TM helix 6	433..460	CDD:320167	5/26 (19%)
		TM helix 7	468..493	CDD:320167	8/33 (24%)
adgrf11	XP_005160858.1	GAIN	143..>227	CDD:293098
		GPS	318..363	CDD:280071
		7tm_4	374..620	CDD:304433	59/282 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810