DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Irbp and YKU70

DIOPT Version :9

Sequence 1:	NP_536773.1	Gene:	Irbp / 117419	FlyBaseID:	FBgn0011774	Length:	631	Species:	Drosophila melanogaster
Sequence 2:	NP_014011.1	Gene:	YKU70 / 855328	SGDID:	S000004897	Length:	602	Species:	Saccharomyces cerevisiae

Alignment Length:	593	Identity:	129/593 - (21%)
Similarity:	224/593 - (37%)	Gaps:	134/593 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 DEEDVSMKRDYHGREAILFVVDAN----LQTAGVE------RLLEALNIIRTAFISGLLVNDKDL 72
            |:.|.:..|.:...|.|||.::.:    .:::.:|      .:||:|:.:.:..:   :......
Yeast    16 DQVDETGYRKFDIHEGILFCIELSETMFKESSDLEYKSPLLEILESLDELMSQLV---ITRPGTA 77

  Fly    73 IGLIF--ANTKHSPPPLEASALDNIVMPDNCAVFLP-----LRQLTKPIVEHYLEFM---GGVET 127
            ||..|  .|.:.:    :....:...:.|..|.|:.     |..|:...:..|..||   .|.|.
Yeast    78 IGCYFYYCNREDA----KEGIYELFPLRDINATFMKKLNDLLEDLSSGRISLYDYFMFQQTGSEK 138

  Fly   128 QFADVYGLAEPDGRGRFDLMIRLCIE-MLEKC--GKKLNNAKIAYVTDVREPHPSNSNHFQAALQ 189
            |.             |..::....:: .||:.  .|:|:|.::...||:.:|..:.....:|.|:
Yeast   139 QV-------------RLSVLFTFMLDTFLEEIPGQKQLSNKRVFLFTDIDKPQEAQDIDERARLR 190

  Fly   190 KAS-DLEGKEFEF--HVIPMVD-DFDYEPFYKEFITL-SRAIE---LDA-FQVPDAQML-REILS 244
            :.: ||...:..|  ..|...| .||.| ||.:.:.| |...|   ||: |..|..:.: .:.:.
Yeast   191 RLTIDLFDNKVNFATFFIGYADKPFDNE-FYSDILQLGSHTNENTGLDSEFDGPSTKPIDAKYIK 254

  Fly   245 DRKLKQDFLRRCLGHFSFYLG--PNLSMSVQYYNYFQRRAYPRKVQILRRDNSVVRTKRVITVQK 307
            .|.|::..::|.:......|.  .|..:.|:.|..:            ..:.:.||.|.|..
Yeast   255 SRILRKKEVKRIMFQCPLILDEKTNFIVGVKGYTMY------------THEKAGVRYKLVYE--- 304

  Fly   308 QKDDGSQDIEHEYQIK-----------VTGGWYTCNV---GERDLRISMDQLNRVRNLHKPQ--- 355
                 .:||..|...|           |||  .|..|   |:.|:.:|..|...|...:..:
Yeast   305 -----HEDIRQEAYSKRKFLNPITGEDVTG--KTVKVYPYGDLDINLSDSQDQIVMEAYTQKDAF 362

  Fly   356 MMLLGFKHRSSLPEVSY---IKPANFMYPDDQSIIGSKRLFRALWERCLVRDKIAICLFMCKRKS 417
            :.::||  |||...:.|   |..::|:.||:....||.|...:|.:....:|||||.....|..|
Yeast   363 LKIIGF--RSSSKSIHYFNNIDKSSFIVPDEAKYEGSIRTLASLLKILRKKDKIAILWGKLKSNS 425

  Fly   418 IPRYVALVPVEAPDNGEDKNYRSLLCGDGFKIVYLPEAKHIRHL-DLQDWNNTENTADEQKVEF- 480
            .|....|.|....|..|           ||.:..:|....||.. .|..:::    ..|.|:::
Yeast   426 HPSLYTLSPSSVKDYNE-----------GFYLYRVPFLDEIRKFPSLLSYDD----GSEHKLDYD 475

  Fly   481 -FQKIIK------KLRVDYQPNLINDPSLD----ALQANLLALSLDF---STDTKGLDNLLDTSQ 531
             .:|:.:      .||..|.|:...:|.|.    .|...||.:...|   .|.....|.::   :
Yeast   476 NMKKVTQSIMGYFNLRDGYNPSDFKNPLLQKHYKVLHDYLLQIETTFDENETPNTKKDRMM---R 537

  Fly   532 QDKRIEKL 539
            :|..:.||
Yeast   538 EDDSLRKL 545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Irbp	NP_536773.1	Ku_N	33..256	CDD:367627	52/255 (20%)
		KU70	255..546	CDD:238407	73/323 (23%)
		HeH	593..624	CDD:338564
YKU70	NP_014011.1	Ku_N	31..267	CDD:397685	53/256 (21%)
YKU70	NP_014011.1	KU70	265..553	CDD:238407	73/323 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343944
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2327
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37483
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5405
OMA	1	1.010	-	-		QHG55383
OrthoFinder	1	1.000	-	-		FOG0005016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102426
Panther	1	1.100	-	-	LDO	PTHR12604
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7418
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.730