DRSC/TRiP Functional Genomics Resources

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Protein Alignment Irbp and XRCC6

DIOPT Version :10

Sequence 1:NP_536773.1 Gene:Irbp / 117419 FlyBaseID:FBgn0011774 Length:631 Species:Drosophila melanogaster
Sequence 2:NP_001460.1 Gene:XRCC6 / 2547 HGNCID:4055 Length:609 Species:Homo sapiens


Alignment Length:661 Identity:160/661 - (24%)
Similarity:291/661 - (44%) Gaps:112/661 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MSTWNP--ENDVDLLSGSEDEEDVSMKRD--YHGREAILFVVDAN---LQTAGVERLLE---ALN 55
            ||.|..  :.:.|..:..|.||::....|  |.||::::|:|||:   .::...:.|..   ::.
Human     1 MSGWESYYKTEGDEEAEEEQEENLEASGDYKYSGRDSLIFLVDASKAMFESQSEDELTPFDMSIQ 65

  Fly    56 IIRTAFISGLLVNDKDLIGLIFANTKHSPPPLEASALDNIVMPDNCAVFLPLRQLTKPIVEHYLE 120
            .|::.:||.::.:|:||:.::|..|:..         .|.|...|..|   |::|..|..:..||
Human    66 CIQSVYISKIISSDRDLLAVVFYGTEKD---------KNSVNFKNIYV---LQELDNPGAKRILE 118

  Fly   121 ---FMGGV-ETQFADV------YGLAEPDGRGRFDLMIRLCIEMLEKCGKKLNNAKIAYVTDVRE 175
               |.|.. :.:|.|:      |.|:|         ::.:|..:......|:::.:|...|:...
Human   119 LDQFKGQQGQKRFQDMMGHGSDYSLSE---------VLWVCANLFSDVQFKMSHKRIMLFTNEDN 174

  Fly   176 PHPSNSNHFQAALQKASDLE--GKEFEFHVIPMVDDFDYEPFYKEFITLSRAIELDAFQVPDAQM 238
            ||.::|.....|..||.||.  |...:...:.....||...||::.|:::...:| .....::..
Human   175 PHGNDSAKASRARTKAGDLRDTGIFLDLMHLKKPGGFDISLFYRDIISIAEDEDL-RVHFEESSK 238

  Fly   239 LREILSDRKLK-QDFLRRCLGHFSFYLGPNLSMSVQYYNYFQRRAYPRKVQILRRDNSVVRTK-R 301
            |.::|  ||:: ::..:|.|......|..::.:||..||..|:...|..:::.|..|..|:|| |
Human   239 LEDLL--RKVRAKETRKRALSRLKLKLNKDIVISVGIYNLVQKALKPPPIKLYRETNEPVKTKTR 301

  Fly   302 VITVQKQKDDGSQDIEHEYQIKVTGGWYTCN-------VGERDLRISMDQLNRVRNLHKPQMMLL 359
            .....                  |||....:       .|.|.:.:..::...::....|.:||:
Human   302 TFNTS------------------TGGLLLPSDTKRSQIYGSRQIILEKEETEELKRFDDPGLMLM 348

  Fly   360 GFKHRSSLPEVSYIKPANFMYPDDQSIIGSKRLFRALWERCLVRDKIAICLFMCKRKSIPRYVAL 424
            |||....|.:..|::|:.|:||::..:|||..||.||..:||.::..|:|.:..:|...|.:|||
Human   349 GFKPLVLLKKHHYLRPSLFVYPEESLVIGSSTLFSALLIKCLEKEVAALCRYTPRRNIPPYFVAL 413

  Fly   425 VPVEAPDNGEDKNYRSLLCGDGFKIVYLPEAKHIRHLDLQDWNNTEN-TADEQKVEFFQKIIKKL 488
            ||.|  :..:|:..:  :...||::|:||.|...|.:..     ||. .|..::|...:.|::||
Human   414 VPQE--EELDDQKIQ--VTPPGFQLVFLPFADDKRKMPF-----TEKIMATPEQVGKMKAIVEKL 469

  Fly   489 RVDYQPNLINDPSLDALQANLLALSLDFSTDTKGLD-NLLDTSQQDKRIEKLLPDYE--MFAPEA 550
            |..|:.:...:|.|.....||.||:||.....:.:| .|......:||:..|:.:::  ::.|:.
Human   470 RFTYRSDSFENPVLQQHFRNLEALALDLMEPEQAVDLTLPKVEAMNKRLGSLVDEFKELVYPPDY 534

  Fly   551 EPHKKRAAKSTTAGASGPKMAKID--DDQLK---------------------EFEFVKSLNKDEA 592
            .|..|...:......||.|..|::  :::||                     .:.....|.|.|.
Human   535 NPEGKVTKRKHDNEGSGSKRPKVEYSEEELKTHISKGTLGKFTVPMLKEACRAYGLKSGLKKQEL 599

  Fly   593 LTSCTAAQLHF 603
            |.:.|.   ||
Human   600 LEALTK---HF 607

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
IrbpNP_536773.1 Ku_N 33..256 CDD:427470 52/241 (22%)
KU70 255..546 CDD:238407 81/302 (27%)
HeH 593..624 CDD:403988 4/11 (36%)
XRCC6NP_001460.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..28 7/26 (27%)
ku70 26..608 CDD:273151 153/636 (24%)
DNA-binding. /evidence=ECO:0000305|PubMed:15023334 277..341 13/81 (16%)
Interaction with XRCC5. /evidence=ECO:0000305|PubMed:15023334 373..482 36/117 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 536..562 6/25 (24%)
Interaction with DEAF1. /evidence=ECO:0000269|PubMed:22442688 550..609 13/61 (21%)
Interaction with BAX. /evidence=ECO:0000305|PubMed:15023334 578..583 0/4 (0%)

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