DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Irbp and cku-70

DIOPT Version :9

Sequence 1:	NP_536773.1	Gene:	Irbp / 117419	FlyBaseID:	FBgn0011774	Length:	631	Species:	Drosophila melanogaster
Sequence 2:	NP_499438.2	Gene:	cku-70 / 176546	WormBaseID:	WBGene00000519	Length:	679	Species:	Caenorhabditis elegans

Alignment Length:	718	Identity:	149/718 - (20%)
Similarity:	271/718 - (37%)	Gaps:	167/718 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 EEDVSMKRDYHGREA----ILFVVDAN---LQTA----------GVERLLEALNIIRTAFISGLL 66
            |:|     |:.|..|    ..|::|.|   .:|:          .::.:|:  .|:|......|
Worm     7 EDD-----DFEGSTANKKYTFFIIDGNPAMFETSKAGEPPEFKLALKLILD--EIVRVCCSRSL- 63

  Fly    67 VNDKDLIGLIFANTKHSPPPLEASALDNIVMPDNCAVFLPLRQLTKPIVEHYLEFMGGVETQFAD 131
               .:.||:|..:||:|    |...|      :|..:.:|:..|.:..|....| :...|...:.
Worm    64 ---NNHIGVIVTSTKNS----ETEGL------ENSTLLVPMGVLGQEEVNKIKE-IAEEENLLSA 114

  Fly   132 VYGLAEPDGRGRFDLMIRLCIEMLEKCGKKLNNAKIAYVTDVREPHPSN----SNHFQAALQKAS 192
            |........:.....::..|..:...| ....:..:.|:|:.|.|...:    |:||:......:
Worm   115 VNNYGGDHHKSDLSNVLNYCKRVFASC-SNTRHQSVIYLTNNRNPFERDDFLESSHFKRTKAAVT 178

  Fly   193 DLEGKEF-----EFHVIPMVDDFDY----------EPFYKEFITLSRAIELDAFQVPDAQMLREI 242
            .:.|:..     ||.||.:.:| .|          ||:| :..|...:.|.||     |..:|:.
Worm   179 KIIGEGHRKTLGEFSVIMLPED-GYKPQDKDEKRKEPWY-DLDTEVFSTECDA-----AARIRQK 236

  Fly   243 LSDRKLKQDFLRRCLGHFSFYLGPNLSMSVQYYNYFQRRAYPRKVQILRRD--NSVVRTKRVITV 305
            ::        .:|.....:..:||.::..|..::...........|...||  ..:|:|...:..
Worm   237 IT--------AQRSHATLTVNVGPGVTFDVSVFSMVMEAKPLDHSQKYTRDTEEKIVKTSGYVKK 293

  Fly   306 QKQKDDGSQDIEHEYQI--KVTGGWYTCNVGE------RDLRISM-----------DQLNRVRNL 351
            :.:.:..|.:||.:..:  :.......|...|      |||:.|:           ||...:..:
Worm   294 ESKMELESTEIETQDSVLDETQKMLIRCKFLEDSIRNRRDLKKSIEIGGEKIILDGDQYEYMNEV 358

  Fly   352 HKPQMMLLGFKHRSSLPEVSYIKPANFMYPDDQSIIGSKRLFRALWERCLVRDKIAICLFMCKRK 416
            :...:..:||...|.:...:.:..:..:.|:||:.:||..::|...:||..|.:..:|.:..:.|
Worm   359 NSKGVDFVGFCSMSRVDRETSVVSSKIIQPNDQTTLGSTAIYRTFLDRCWARQQAIVCKYQSRSK 423

  Fly   417 SIPRYVALVPVEAP--------DNGEDKN-------------------YRSLLCGDGFKIVYLPE 454
            ...|.:||||.:..        :||||.:                   ..|....:||.:|..|.
Worm   424 QKMRLMALVPFKKDMTLIEKRHENGEDDDDMEDKKPDLLRLEQQRAQADSSEWLHEGFMLVGQPF 488

  Fly   455 AKHIRHLDLQDWNNTENT----ADEQKVEFFQKIIKKLRVDYQPNLINDPSLDALQANLLALSLD 515
            .:.:|. |.:.:...:|.    :.|::|...::.:|:|.:.|.|:...:|.|.:.::   ||.|:
Worm   489 REELRD-DFKRFEEQQNVLTEPSTEEQVNTMKQFVKRLTMSYNPSFYENPRLLSERS---ALCLE 549

  Fly   516 FSTD--TKGLDNLLDTSQQDKR-------IEKLLPDYEMFAPEAEPHKKRAAKSTTAGASGPKMA 571
            .:.:  .:..|.|....|..||       |||::   |.||...|      .|.|...||..:..
Worm   550 ATGEELIERRDTLEPYYQIPKRLQRVGTEIEKIV---ETFALNDE------IKETKPKASAGRKR 605

  Fly   572 KIDDDQLKEFEFVKSLNKDEALT--SCTAAQ----------LHFILQHHFDVTMPKSSKKAKLVA 624
            |.|||:       .|.:|...:|  .|.||.          |...::|.......||..|..::|
Worm   606 KTDDDE-------PSTSKKATMTIRDCIAADKIGKFKKDELLSMAVEHCEASKSLKSKTKNDIIA 663

  Fly   625 KIE 627
            .||
Worm   664 VIE 666

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Irbp	NP_536773.1	Ku_N	33..256	CDD:367627	49/258 (19%)
		KU70	255..546	CDD:238407	71/351 (20%)
		HeH	593..624	CDD:338564	9/42 (21%)
cku-70	NP_499438.2	Ku_N	20..243	CDD:367627	49/255 (19%)
cku-70	NP_499438.2	KU70	241..583	CDD:238407	70/345 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159639
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2327
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37483
Inparanoid	1	1.050	66	1.000	Inparanoid score	I3955
Isobase	1	0.950	-	0	Normalized mean entropy	S5405
OMA	1	1.010	-	-		QHG55383
OrthoDB	1	1.010	-	-		D402798at2759
OrthoFinder	1	1.000	-	-		FOG0005016
OrthoInspector	1	1.000	-	-		oto18350
orthoMCL	1	0.900	-	-		OOG6_102426
Panther	1	1.100	-	-	LDO	PTHR12604
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7418
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.750