DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Irbp and Xrcc6

DIOPT Version :9

Sequence 1:	NP_536773.1	Gene:	Irbp / 117419	FlyBaseID:	FBgn0011774	Length:	631	Species:	Drosophila melanogaster
Sequence 2:	NP_034377.2	Gene:	Xrcc6 / 14375	MGIID:	95606	Length:	608	Species:	Mus musculus

Alignment Length:	660	Identity:	171/660 - (25%)
Similarity:	305/660 - (46%)	Gaps:	82/660 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSTWNPENDVDLLSGSEDEE-----DVSMKRDYHGREAILFVVDAN---LQTAGVERLLE---AL 54
            ||.|......:   |.|:||     |...:..|.||::::|:|||:   .::.|.:.|..   ::
Mouse     1 MSEWESYYKTE---GEEEEEEEESPDTGGEYKYSGRDSLIFLVDASRAMFESQGEDELTPFDMSI 62

  Fly    55 NIIRTAFISGLLVNDKDLIGLIFANTKHSPPPLEASALDNIVMPDNCAVFLPLRQLTKPIVEHYL 119
            ..|::.:.|.::.:|:||:.::|..|:..         .|.|...|..|   |:.|..|..:..|
Mouse    63 QCIQSVYTSKIISSDRDLLAVVFYGTEKD---------KNSVNFKNIYV---LQDLDNPGAKRVL 115

  Fly   120 E---FMGGV-ETQFADV------YGLAEPDGRGRFDLMIRLCIEMLEKCGKKLNNAKIAYVTDVR 174
            |   |.|.. :..|.|.      |.|:|         ::.:|..:......|:::.:|...|:..
Mouse   116 ELDQFKGQQGKKHFRDTVGHGSDYSLSE---------VLWVCANLFSDVQLKMSHKRIMLFTNED 171

  Fly   175 EPHPSNSNHFQAALQKASDLE--GKEFEFHVIPMVDDFDYEPFYKEFITLSRAIELDAFQVPDAQ 237
            :||..:|.....|..|||||.  |...:...:.....||...||::.||.:...:| .....::.
Mouse   172 DPHGRDSAKASRARTKASDLRDTGIFLDLMHLKKPGGFDVSVFYRDIITTAEDEDL-GVHFEESS 235

  Fly   238 MLREILSDRKLK-QDFLRRCLGHFSFYLGPNLSMSVQYYNYFQRRAYPRKVQILRRDNSVVRTK- 300
            .|.::|  ||:: ::..:|.|....|.||.::.:.|..||..|:...|..|::.|..|..|:||
Mouse   236 KLEDLL--RKVRAKETKKRVLSRLKFKLGEDVVLMVGIYNLVQKANKPFPVRLYRETNEPVKTKT 298

  Fly   301 RVITVQKQKDDGSQDIEHEYQIKVTGGWYTCNVGERDLRISMDQLNRVRNLHKPQMMLLGFKHRS 365
            |...|    :.||..:..:.:..:|       .|.|.:.:..::...::...:|.::|:|||...
Mouse   299 RTFNV----NTGSLLLPSDTKRSLT-------YGTRQIVLEKEETEELKRFDEPGLILMGFKPTV 352

  Fly   366 SLPEVSYIKPANFMYPDDQSIIGSKRLFRALWERCLVRDKIAICLFMCKRKSIPRYVALVPVEAP 430
            .|.:..|::|:.|:||::..:.||..||.||..:|:.::.||:|.:..::...|.:|||||.|
Mouse   353 MLKKQHYLRPSLFVYPEESLVSGSSTLFSALLTKCVEKEVIAVCRYTPRKNVSPYFVALVPQE-- 415

  Fly   431 DNGEDKNYRSLLCGDGFKIVYLPEAKHIRHLDLQDWNNTEN-TADEQKVEFFQKIIKKLRVDYQP 494
            :..:|:|.:  :...||::|:||.|...|.:..     ||. ||::::::..:.|::|||..|:.
Mouse   416 EELDDQNIQ--VTPGGFQLVFLPYADDKRKVPF-----TEKVTANQEQIDKMKAIVQKLRFTYRS 473

  Fly   495 NLINDPSLDALQANLLALSLDFSTDTKGLDNLLDTSQQ-DKRIEKLLPDYE--MFAPEAEPHKKR 556
            :...:|.|.....||.||:||.....:.:|..|...:. .||:..|..:::  ::.|...|..|.
Mouse   474 DSFENPVLQQHFRNLEALALDMMESEQVVDLTLPKVEAIKKRLGSLADEFKELVYPPGYNPEGKV 538

  Fly   557 AAKSTTAGASGPKMAKIDDDQLKEFEFVKSLNKDEALTSCTAAQLHFILQHHFDVTMPKSSKKAK 621
            |.:......|..|..|:   :|.| |.:|:..:...|...|...|..|.:.|...:.||  |:..
Mouse   539 AKRKQDDEGSTSKKPKV---ELSE-EELKAHFRKGTLGKLTVPTLKDICKAHGLKSGPK--KQEL 597

  Fly   622 LVAKIEELHK 631
            |.|.|..|.|
Mouse   598 LDALIRHLEK 607

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Irbp	NP_536773.1	Ku_N	33..256	CDD:367627	54/241 (22%)
		KU70	255..546	CDD:238407	82/295 (28%)
		HeH	593..624	CDD:338564	9/30 (30%)
Xrcc6	NP_034377.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..29		8/30 (27%)
		ku70	22..606	CDD:273151	162/633 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	534..557		6/25 (24%)
		Interaction with DEAF1. /evidence=ECO:0000250	548..607		19/64 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837724
Domainoid	1	1.000	86	1.000	Domainoid score	I8152
eggNOG	1	0.900	-	-		E1_KOG2327
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37483
Inparanoid	1	1.050	164	1.000	Inparanoid score	I4189
Isobase	1	0.950	-	0	Normalized mean entropy	S5405
OMA	1	1.010	-	-		QHG55383
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005016
OrthoInspector	1	1.000	-	-		oto94179
orthoMCL	1	0.900	-	-		OOG6_102426
Panther	1	1.100	-	-	LDO	PTHR12604
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7418
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.740