Protein Alignment Irbp and Xrcc6

DIOPT Version :10

• Sequence 1: NP_536773.1
• Gene: Irbp / 117419
• FlyBaseID: FBgn0011774
• Length: 631
• Species: Drosophila melanogaster
• Sequence 2: NP_034377.2
• Gene: Xrcc6 / 14375
• MGIID: 95606
• Length: 608
• Species: Mus musculus
• Alignment Length: 660
• Identity: 171/660 - (25%)
• Similarity: 305/660 - (46%)
• Gaps: 82/660 - (12%)

  Fly     1 MSTWNPENDVDLLSGSEDEE-----DVSMKRDYHGREAILFVVDAN---LQTAGVERLLE---AL 54
            ||.|......:   |.|:||     |...:..|.||::::|:|||:   .::.|.:.|..   ::
Mouse     1 MSEWESYYKTE---GEEEEEEEESPDTGGEYKYSGRDSLIFLVDASRAMFESQGEDELTPFDMSI 62

  Fly    55 NIIRTAFISGLLVNDKDLIGLIFANTKHSPPPLEASALDNIVMPDNCAVFLPLRQLTKPIVEHYL 119
            ..|::.:.|.::.:|:||:.::|..|:..         .|.|...|..|   |:.|..|..:..|
Mouse    63 QCIQSVYTSKIISSDRDLLAVVFYGTEKD---------KNSVNFKNIYV---LQDLDNPGAKRVL 115

  Fly   120 E---FMGGV-ETQFADV------YGLAEPDGRGRFDLMIRLCIEMLEKCGKKLNNAKIAYVTDVR 174
            |   |.|.. :..|.|.      |.|:|         ::.:|..:......|:::.:|...|:..
Mouse   116 ELDQFKGQQGKKHFRDTVGHGSDYSLSE---------VLWVCANLFSDVQLKMSHKRIMLFTNED 171

  Fly   175 EPHPSNSNHFQAALQKASDLE--GKEFEFHVIPMVDDFDYEPFYKEFITLSRAIELDAFQVPDAQ 237
            :||..:|.....|..|||||.  |...:...:.....||...||::.||.:...:| .....::.
Mouse   172 DPHGRDSAKASRARTKASDLRDTGIFLDLMHLKKPGGFDVSVFYRDIITTAEDEDL-GVHFEESS 235

  Fly   238 MLREILSDRKLK-QDFLRRCLGHFSFYLGPNLSMSVQYYNYFQRRAYPRKVQILRRDNSVVRTK- 300
            .|.::|  ||:: ::..:|.|....|.||.::.:.|..||..|:...|..|::.|..|..|:||
Mouse   236 KLEDLL--RKVRAKETKKRVLSRLKFKLGEDVVLMVGIYNLVQKANKPFPVRLYRETNEPVKTKT 298

  Fly   301 RVITVQKQKDDGSQDIEHEYQIKVTGGWYTCNVGERDLRISMDQLNRVRNLHKPQMMLLGFKHRS 365
            |...|    :.||..:..:.:..:|       .|.|.:.:..::...::...:|.::|:|||...
Mouse   299 RTFNV----NTGSLLLPSDTKRSLT-------YGTRQIVLEKEETEELKRFDEPGLILMGFKPTV 352

  Fly   366 SLPEVSYIKPANFMYPDDQSIIGSKRLFRALWERCLVRDKIAICLFMCKRKSIPRYVALVPVEAP 430
            .|.:..|::|:.|:||::..:.||..||.||..:|:.::.||:|.:..::...|.:|||||.|
Mouse   353 MLKKQHYLRPSLFVYPEESLVSGSSTLFSALLTKCVEKEVIAVCRYTPRKNVSPYFVALVPQE-- 415

  Fly   431 DNGEDKNYRSLLCGDGFKIVYLPEAKHIRHLDLQDWNNTEN-TADEQKVEFFQKIIKKLRVDYQP 494
            :..:|:|.:  :...||::|:||.|...|.:..     ||. ||::::::..:.|::|||..|:.
Mouse   416 EELDDQNIQ--VTPGGFQLVFLPYADDKRKVPF-----TEKVTANQEQIDKMKAIVQKLRFTYRS 473

  Fly   495 NLINDPSLDALQANLLALSLDFSTDTKGLDNLLDTSQQ-DKRIEKLLPDYE--MFAPEAEPHKKR 556
            :...:|.|.....||.||:||.....:.:|..|...:. .||:..|..:::  ::.|...|..|.
Mouse   474 DSFENPVLQQHFRNLEALALDMMESEQVVDLTLPKVEAIKKRLGSLADEFKELVYPPGYNPEGKV 538

  Fly   557 AAKSTTAGASGPKMAKIDDDQLKEFEFVKSLNKDEALTSCTAAQLHFILQHHFDVTMPKSSKKAK 621
            |.:......|..|..|:   :|.| |.:|:..:...|...|...|..|.:.|...:.||  |:..
Mouse   539 AKRKQDDEGSTSKKPKV---ELSE-EELKAHFRKGTLGKLTVPTLKDICKAHGLKSGPK--KQEL 597

  Fly   622 LVAKIEELHK 631
            |.|.|..|.|
Mouse   598 LDALIRHLEK 607

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Irbp	NP_536773.1	Ku_N	33..256	CDD:427470	54/241 (22%)
		KU70	255..546	CDD:238407	82/295 (28%)
		HeH	593..624	CDD:403988	9/30 (30%)
Xrcc6	NP_034377.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..29		8/30 (27%)
		ku70	22..606	CDD:273151	162/633 (26%)
		DNA-binding. /evidence=ECO:0000250|UniProtKB:P12956	275..339		15/74 (20%)
		Interaction with XRCC5. /evidence=ECO:0000250|UniProtKB:P12956	371..480		35/117 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	534..557		6/25 (24%)
		Interaction with DEAF1. /evidence=ECO:0000250	548..607		19/64 (30%)
		Interaction with BAX. /evidence=ECO:0000250|UniProtKB:P12956	576..581		1/4 (25%)