Protein Alignment Tsp68C and TSPAN8

DIOPT Version :10

• Sequence 1: NP_729926.1
• Gene: Tsp68C / 117407
• FlyBaseID: FBgn0043550
• Length: 362
• Species: Drosophila melanogaster
• Sequence 2: NP_004607.1
• Gene: TSPAN8 / 7103
• HGNCID: 11855
• Length: 237
• Species: Homo sapiens
• Alignment Length: 273
• Identity: 56/273 - (20%)
• Similarity: 122/273 - (44%)
• Gaps: 51/273 - (18%)

  Fly     1 MACCFNYKFVLNLCNFLFLICGLLLVVSGLY--IFSDNKRILLSRLLAASSDRLSSLPQPLLFYI 63
            ::.|..|.  :...||||.:||:|::...::  :.:|::.|..|..:.:||            |:
Human     4 VSACIKYS--MFTFNFLFWLCGILILALAIWVRVSNDSQAIFGSEDVGSSS------------YV 54

  Fly    64 ALGVAIAGFVATLAAVVGFWASC---LHTYCFLTIYFLSVVVLLLTESVLCLAITLWPHCLGISL 125
            |:.:.||  |..:..::||...|   ..:.|.|.::|:.::::||.:....:...::.......:
Human    55 AVDILIA--VGAIIMILGFLGCCGAIKESRCMLLLFFIGLLLILLLQVATGILGAVFKSKSDRIV 117

  Fly   126 DETQMVRSLQSNYGVPGQEQFTNALDLAQVRFGCCGM-RSSLDYDTSLWRLQGYGQRNWPVPLSC 189
            :||....:...:.....::||..|:.:.|..|.|||: ..:.|:        |...:::|...:|
Human   118 NETLYENTKLLSATGESEKQFQEAIIVFQEEFKCCGLVNGAADW--------GNNFQHYPELCAC 174

  Fly   190 CFLKNAGHSMAYLDPKPANESMCQSLERLSYERERHTESCLPHLDNWYREQYSIFLGASLILAMI 254
                        ||    .:..|||..    .::.:.|:|:..:.::..:...|.:|.|..||:|
Human   175 ------------LD----KQRPCQSYN----GKQVYKETCISFIKDFLAKNLIIVIGISFGLAVI 219

  Fly   255 EFC-VLLAIIMSC 266
            |.. ::.::::.|
Human   220 EILGLVFSMVLYC 232

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tsp68C	NP_729926.1	Tetraspanin	8..>161	CDD:459767	33/157 (21%)
		tetraspanin_LEL	117..241	CDD:239401	21/124 (17%)
TSPAN8	NP_004607.1	Tetraspanin	8..232	CDD:459767	54/267 (20%)
		hydrophobic region	10..33		8/24 (33%)
		hydrophobic region	58..78		6/21 (29%)
		hydrophobic region	83..109		5/25 (20%)
		TM4SF3_like_LEL	106..206	CDD:239407	21/127 (17%)
		hydrophobic region	206..232		7/25 (28%)