Protein Alignment Tsp68C and UPK1A

DIOPT Version :10

• Sequence 1: NP_729926.1
• Gene: Tsp68C / 117407
• FlyBaseID: FBgn0043550
• Length: 362
• Species: Drosophila melanogaster
• Sequence 2: XP_054175633.1
• Gene: UPK1A / 11045
• HGNCID: 12577
• Length: 313
• Species: Homo sapiens
• Alignment Length: 224
• Identity: 48/224 - (21%)
• Similarity: 89/224 - (39%)
• Gaps: 30/224 - (13%)

  Fly    15 NFLFLICGLLLVVSGLYIFSDNKRILLSRLLAASSDRLSSLPQPLLFYIALGVAIAGFVATLAAV 79
            |.:.|:.||.|....:::.:|..|:.....::...|..:..      :||:   ..||...:.|.
Human    25 NIIILLSGLSLFAETIWVTADQYRVYPLMGVSGKDDVFAGA------WIAI---FCGFSFFMVAS 80

  Fly    80 VGFWASCLHTYCFLTIYFLSVVVLLLTESVLCLAITLWPHCLGISLDETQMVRSLQSNYGV---P 141
            .|..|:.......:..|.:.::::.:.|...|  ||.:.|...:..:.:.:.:.:.:.|..   .
Human    81 FGVGAALCRRRSMVLTYLVLMLIVYIFECASC--ITSYTHRDYMVSNPSLITKQMLTFYSADTDQ 143

  Fly   142 GQEQFTNALDLAQVRFGCCGMRSSLDY--DTSLWRLQGYGQRNWPVPLSCCFLKNAGHSMAYLDP 204
            ||| .|...|...:...|||....:|:  .||.:| ....:..:|.|..||  :..|:.:
Human   144 GQE-LTRLWDRVMIEQECCGTSGPMDWVNFTSAFR-AATPEVVFPWPPLCC--RRTGNFI----- 199

  Fly   205 KPANESMCQSLERLSYERERHTESCLPHL 233
             |.||..|    ||.:.....|:.|..|:
Human   200 -PLNEEGC----RLGHMDYLFTKGCFEHI 223

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tsp68C	NP_729926.1	Tetraspanin	8..>161	CDD:459767	28/148 (19%)
		tetraspanin_LEL	117..241	CDD:239401	28/122 (23%)
UPK1A	XP_054175633.1	Tetraspanin	25..>163	CDD:459767	29/149 (19%)
		uroplakin_I_like_LEL	113..231	CDD:239409	30/125 (24%)